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The declining response rates in probability surveys along with the widespread availability of unstructured data has led to growing research into non-probability samples. Existing robust approaches are not well-developed for non-Gaussian…

统计方法学 · 统计学 2022-03-29 Ali Rafei , Michael R. Elliott , Carol A. C. Flannagan

Typically, case-control studies to estimate odds-ratios associating risk factors with disease incidence from logistic regression only include cases with newly diagnosed disease. Recently proposed methods allow incorporating information on…

统计方法学 · 统计学 2020-10-19 Soutrik Mandal , Jing Qin , Ruth M. Pfeiffer

Quantile regression is a powerful tool for detecting exposure-outcome associations given covariates across different parts of the outcome's distribution, but has two major limitations when the aim is to infer the effect of an exposure.…

When testing many hypotheses, often we do not have strong expectations about the directions of the effects. In some situations however, the alternative hypotheses are that the parameters lie in a certain direction or interval, and it is in…

统计方法学 · 统计学 2026-03-02 Jesse Hemerik

Analysis of longitudinal Electronic Health Record (EHR) data is an important goal for precision medicine. Difficulty in applying Machine Learning (ML) methods, either predictive or unsupervised, stems in part from the heterogeneity and…

One central goal of design of observational studies is to embed non-experimental data into an approximate randomized controlled trial using statistical matching. Despite empirical researchers' best intention and effort to create…

统计方法学 · 统计学 2022-06-22 Kan Chen , Siyu Heng , Qi Long , Bo Zhang

Chronic diseases such as diabetes pose significant management challenges, particularly due to the risk of complications like hypoglycemia, which require timely detection and intervention. Continuous health monitoring through wearable…

机器学习 · 计算机科学 2026-01-08 Vaibhav Gupta , Florian Grensing , Beyza Cinar , Maria Maleshkova

Aggregate outcome variables collected through surveys and administrative records are often subject to systematic measurement error. For instance, in disaster loss databases, county-level losses reported may differ from the true damages due…

机器学习 · 计算机科学 2026-03-17 Saketh Vishnubhatla , Shu Wan , Andre Harrison , Adrienne Raglin , Huan Liu

A sensitivity analysis in an observational study assesses the robustness of significant findings to unmeasured confounding. While sensitivity analyses in matched observational studies have been well addressed when there is a single outcome…

统计方法学 · 统计学 2015-11-05 Colin B. Fogarty , Dylan S. Small

Publication bias occurs when the publication of research results depends not only on the quality of the research but also on its nature and direction. The consequence is that published studies may not be truly representative of all valid…

统计方法学 · 统计学 2020-02-13 Chuan Hong , Jing Zhang , Yang Li , Elena Elia , Richard Riley , Yong Chen

In epidemiological studies, it is common to analyze disease risk by categorizing continuous variables, such as calorie and nutrient intake, for interpretability. When the original continuous variable is contaminated with measurement errors,…

统计方法学 · 统计学 2025-11-11 Huali Zhao , Tianying Wang

In matched observational studies with continuous treatments, individuals with different treatment doses but the same or similar covariate values are paired for causal inference. While inexact covariate matching (i.e., covariate imbalance…

统计方法学 · 统计学 2025-02-13 Anthony Frazier , Siyu Heng , Wen Zhou

Linear regression with measurement error in the covariates is a heavily studied topic, however, the statistics/econometrics literature is almost silent to estimating a multi-equation model with measurement error. This paper considers a…

统计方法学 · 统计学 2020-06-15 Georges Bresson , Anoop Chaturvedi , Mohammad Arshad Rahman , Shalabh

Measurements are generally collected as unilateral or bilateral data in clinical trials or observational studies. For example, in ophthalmology studies, the primary outcome is often obtained from one eye or both eyes of an individual. In…

统计方法学 · 统计学 2021-11-01 Kejia Wang , Chang-Xing Ma

Electronic Health Record (EHR) has emerged as a valuable source of data for translational research. To leverage EHR data for risk prediction and subsequently clinical decision support, clinical endpoints are often time to onset of a…

统计方法学 · 统计学 2023-11-07 Yang Wang , Qingning Zhou , Tianxi Cai , Xuan Wang

Understanding how biomarker distributions evolve over time is a central challenge in digital health and chronic disease monitoring. In diabetes, changes in the distribution of glucose measurements can reveal patterns of disease progression…

机器学习 · 统计学 2026-03-26 Antonio Álvarez-López , Marcos Matabuena

Imputation is a popular technique for handling item nonresponse in survey sampling. Parametric imputation is based on a parametric model for imputation and is less robust against the failure of the imputation model. Nonparametric imputation…

统计方法学 · 统计学 2019-09-20 Danhyang Lee , Jae Kwang Kim

In the first stage of a two-stage study, the researcher uses a statistical model to impute the unobserved exposures. In the second stage, imputed exposures serve as covariates in epidemiological models. Imputation error in the first stage…

应用统计 · 统计学 2021-07-19 Ron Sarafian , Itai Kloog , Jonathan D. Rosenblatt

It is common to conduct causal inference in matched observational studies by proceeding as though treatment assignments within matched sets are assigned uniformly at random and using this distribution as the basis for inference. This…

统计方法学 · 统计学 2023-11-14 Samuel D. Pimentel , Yaxuan Huang

Clinical time-series forecasting is increasingly studied for decision support, yet standard aggregate metrics can obscure whether a model is actually useful for the task it is meant to serve. In safety-critical settings, low average error…

机器学习 · 计算机科学 2026-05-04 Alireza Namazi , Heman Shakeri
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