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This doctoral thesis covers some of my advances in electron microscopy with deep learning. Highlights include a comprehensive review of deep learning in electron microscopy; large new electron microscopy datasets for machine learning,…

图像与视频处理 · 电气工程与系统科学 2021-03-12 Jeffrey M. Ede

Quantitative microstructural characterization is fundamental to materials science, where electron micrograph (EM) provides indispensable high-resolution insights. However, progress in deep learning-based EM characterization has been…

计算机视觉与模式识别 · 计算机科学 2025-08-25 Nan wang , Zhiyi Xia , Yiming Li , Shi Tang , Zuxin Fan , Xi Fang , Haoyi Tao , Xiaochen Cai , Guolin Ke , Linfeng Zhang , Yanhui Hong

We propose a new microscopy simulation system that can depict atomistic models in a micrograph visual style, similar to results of physical electron microscopy imaging. This system is scalable, able to represent simulation of electron…

定量方法 · 定量生物学 2026-03-27 Ngan Nguyen , Feng Liang , Dominik Engel , Ciril Bohak , Peter Wonka , Timo Ropinski , Ivan Viola

Compressed sensing algorithms are used to decrease electron microscope scan time and electron beam exposure with minimal information loss. Following successful applications of deep learning to compressed sensing, we have developed a…

图像与视频处理 · 电气工程与系统科学 2020-05-21 Jeffrey M. Ede , Richard Beanland

Automated analysis of electron microscopy datasets poses multiple challenges, such as limitation in the size of the training dataset, variation in data distribution induced by variation in sample quality and experiment conditions, etc. It…

材料科学 · 物理学 2022-09-07 Arun Baskaran , Yulin Lin , Jianguo Wen , Maria K. Y. Chan

Electron and scanning probe microscopy produce vast amounts of data in the form of images or hyperspectral data, such as EELS or 4D STEM, that contain information on a wide range of structural, physical, and chemical properties of…

机器学习 · 计算机科学 2023-06-09 Arpan Biswas , Maxim Ziatdinov , Sergei V. Kalinin

Neuron segmentation from electron microscopy (EM) volumes is crucial for understanding brain circuits, yet the complex neuronal structures in high-resolution EM images present significant challenges. EM data exhibits unique characteristics…

计算机视觉与模式识别 · 计算机科学 2025-08-26 Yinda Chen , Haoyuan Shi , Xiaoyu Liu , Te Shi , Ruobing Zhang , Dong Liu , Zhiwei Xiong , Feng Wu

Visualizing high-dimensional data has been a focus in data analysis communities for decades, which has led to the design of many algorithms, some of which are now considered references (such as t-SNE for example). In our era of overwhelming…

机器学习 · 计算机科学 2017-02-21 Johan Paratte , Nathanaël Perraudin , Pierre Vandergheynst

Neural networks are promising tools for high-throughput and accurate transmission electron microscopy (TEM) analysis of nanomaterials, but are known to generalize poorly on data that is "out-of-distribution" from their training data. Given…

材料科学 · 物理学 2023-06-22 Katherine Sytwu , Luis Rangel DaCosta , Mary C. Scott

Medical images are acquired at high resolutions with large fields of view in order to capture fine-grained features necessary for clinical decision-making. Consequently, training deep learning models on medical images can incur large…

The advent of modern, high-speed electron detectors has made the collection of multidimensional hyperspectral transmission electron microscopy datasets, such as 4D-STEM, a routine. However, many microscopists find such experiments daunting…

Environmental microorganisms (EMs) are ubiquitous around us and have an important impact on the survival and development of human society. However, the high standards and strict requirements for the preparation of environmental…

计算机视觉与模式识别 · 计算机科学 2022-04-26 Peng Zhao , Chen Li , Md Mamunur Rahaman , Hao Xu , Pingli Ma , Hechen Yang , Hongzan Sun , Tao Jiang , Ning Xu , Marcin Grzegorzek

Compressed sensing can increase resolution, and decrease electron dose and scan time of electron microscope point-scan systems with minimal information loss. Building on a history of successful deep learning applications in compressed…

图像与视频处理 · 电气工程与系统科学 2019-10-28 Jeffrey M. Ede

Deep Learning has revolutionized various fields, including Computer Vision, Natural Language Processing, as well as Biomedical research. Within the field of neuroscience, specifically in electrophysiological neuroimaging, researchers are…

机器学习 · 计算机科学 2022-04-14 Dung Truong , Manisha Sinha , Kannan Umadevi Venkataraju , Michael Milham , Arnaud Delorme

We present the self-encoder, a neural network trained to guess the identity of each data sample. Despite its simplicity, it learns a very useful representation of data, in a self-supervised way. Specifically, the self-encoder learns to…

机器学习 · 计算机科学 2023-06-27 Armand Boschin , Thomas Bonald , Marc Jeanmougin

Echocardiography is essential to modern cardiology. However, human interpretation limits high throughput analysis, limiting echocardiography from reaching its full clinical and research potential for precision medicine. Deep learning is a…

计算机视觉与模式识别 · 计算机科学 2017-06-28 Ali Madani , Ramy Arnaout , Mohammad Mofrad , Rima Arnaout

State-of-the-art electron microscopes such as scanning electron microscopes (SEM), scanning transmission electron microscopes (STEM) and transmission electron microscopes (TEM) have become increasingly sophisticated. However, the quality of…

计算物理 · 物理学 2023-03-31 I. Lobato , T. Friedrich , S. Van Aert

Vision models pretrained on large-scale RGB natural image datasets are widely reused for electron microscopy image segmentation. In electron microscopy, volumetric data are acquired as serial sections and processed as stacks of adjacent…

计算机视觉与模式识别 · 计算机科学 2026-02-17 Zsófia Molnár , Gergely Szabó , András Horváth

Cryo-electron tomography (cryo-ET) is an imaging technique that allows three-dimensional visualization of macro-molecular assemblies under near-native conditions. Cryo-ET comes with a number of challenges, mainly low signal-to-noise and…

A key obstacle in automated analytics and meta-learning is the inability to recognize when different datasets contain measurements of the same variable. Because provided attribute labels are often uninformative in practice, this task may be…

机器学习 · 计算机科学 2019-09-12 Jonas Mueller , Alex Smola
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