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Inference on unknown quantities in dynamical systems via observational data is essential for providing meaningful insight, furnishing accurate predictions, enabling robust control, and establishing appropriate designs for future…

统计方法学 · 统计学 2018-02-06 M. Chung , M. Binois , R. B. Gramacy , D. J. Moquin , A. P. Smith , A. M. Smith

Handling missing data is a central challenge in data-driven analysis. Modern imputation methods not only aim for accurate reconstruction but also differ in how they represent and quantify uncertainty. Yet, the reliability and calibration of…

数据库 · 计算机科学 2025-11-27 Zarin Tahia Hossain , Mostafa Milani

Missing data arise in most applied settings and are ubiquitous in electronic health records (EHR). When data are missing not at random (MNAR) with respect to measured covariates, sensitivity analyses are often considered. These post-hoc…

统计方法学 · 统计学 2023-07-11 Alexander W. Levis , Rajarshi Mukherjee , Rui Wang , Heidi Fischer , Sebastien Haneuse

This study investigates the impact of masking strategies on time series imputation models in healthcare settings. While current approaches predominantly rely on random masking for model evaluation, this practice fails to capture the…

机器学习 · 计算机科学 2025-02-05 Linglong Qian , Yiyuan Yang , Wenjie Du , Jun Wang , Richard Dobsoni , Zina Ibrahim

Predictive modeling with electronic health record (EHR) data is anticipated to drive personalized medicine and improve healthcare quality. Constructing predictive statistical models typically requires extraction of curated predictor…

In electronic health records (EHRs), latent subgroups of patients may exhibit distinctive patterning in their longitudinal health trajectories. For such data, growth mixture models (GMMs) enable classifying patients into different latent…

统计方法学 · 统计学 2022-01-12 Rebecca Anthopolos , Ying Wei , Qixuan Chen

One major impediment to the wider use of deep learning for clinical decision making is the difficulty of assigning a level of confidence to model predictions. Currently, deep Bayesian neural networks and sparse Gaussian processes are the…

Electronic Health Record (EHR) provides abundant information through various modalities. However, learning multi-modal EHR is currently facing two major challenges, namely, 1) data embedding and 2) cases with missing modality. A lack of…

机器学习 · 计算机科学 2023-05-05 Kwanhyung Lee , Soojeong Lee , Sangchul Hahn , Heejung Hyun , Edward Choi , Byungeun Ahn , Joohyung Lee

Heart failure (HF) discharge planning depends on identifying patients at risk of deterioration or death, yet accurate prediction from routinely collected electronic health records (EHRs) remains challenging. We developed and validated…

Advancements in data collection techniques and the heterogeneity of data resources can yield high percentages of missing observations on variables, such as block-wise missing data. Under missing-data scenarios, traditional methods such as…

统计方法学 · 统计学 2022-05-17 Wei Lan , Xuerong Chen , Tao Zou , Chih-Ling Tsai

Electronic Medical Records (EMR) are a rich source of patient information, including measurements reflecting physiologic signs and administered therapies. Identifying which variables are useful in predicting clinical outcomes can be…

机器学习 · 统计学 2019-04-03 Eugene Laksana , Melissa Aczon , Long Ho , Cameron Carlin , David Ledbetter , Randall Wetzel

We describe the Bedside Patient Rescue (BPR) project, the goal of which is risk prediction of adverse events for non-ICU patients using ~200 variables (vitals, lab results, assessments, ...). There are several missing predictor values for…

Electronic Health Records (EHR) are high-dimensional data with implicit connections among thousands of medical concepts. These connections, for instance, the co-occurrence of diseases and lab-disease correlations can be informative when…

机器学习 · 计算机科学 2021-03-29 Weicheng Zhu , Narges Razavian

Statistical learning with a large number of rare binary features is commonly encountered in analyzing electronic health records (EHR) data, especially in the modeling of disease onset with prior medical diagnoses and procedures. Dealing…

机器学习 · 计算机科学 2024-02-28 Jianmin Chen , Robert H. Aseltine , Fei Wang , Kun Chen

BACKGROUND: As databases grow larger, it becomes harder to fully control their collection, and they frequently come with missing values: incomplete observations. These large databases are well suited to train machine-learning models, for…

机器学习 · 计算机科学 2022-02-23 Alexandre Perez-Lebel , Gaël Varoquaux , Marine Le Morvan , Julie Josse , Jean-Baptiste Poline

Learning a medical image segmentation model is an inherently ambiguous task, as uncertainties exist in both images (noise) and manual annotations (human errors and bias) used for model training. To build a trustworthy image segmentation…

图像与视频处理 · 电气工程与系统科学 2023-08-17 Xinyu Bai , Wenjia Bai

Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels and according to World Health Organization is the leading cause of death worldwide. EHR data regarding this case, as well as medical cases in…

机器学习 · 计算机科学 2022-11-08 Konstantinos Psychogyios , Loukas Ilias , Dimitris Askounis

Accurately predicting hospital readmission risks using electronic health records (EHRs) is critical for effective patient management and healthcare resource allocation. Patient populations in health systems are highly heterogeneous across…

统计方法学 · 统计学 2026-04-22 Ziren Jiang , Lingfeng Huo , Jue Hou , Mary Vaughan-Sarrazin , Maureen A. Smith , Jared D. Huling

We aim to incorporate variable selection routines into variable-by-variable (or sequential) imputation in clustered data to achieve computational improvement in applications with large-scale health data. Specifically, we utilize variable…

统计方法学 · 统计学 2025-04-08 Qiushuang Li , Recai Yucel

Electronic health records (EHRs) are invaluable for clinical research, yet privacy concerns severely restrict data sharing. Synthetic data generation offers a promising solution, but EHRs present unique challenges: they contain both…

机器学习 · 计算机科学 2026-03-26 Shaonan Liu , Yuichiro Iwashita , Soichiro Nakako , Masakazu Iwamura , Koichi Kise