相关论文: AnySeq: A High Performance Sequence Alignment Libr…

We propose Dense FixMatch, a simple method for online semi-supervised learning of dense and structured prediction tasks combining pseudo-labeling and consistency regularization via strong data augmentation. We enable the application of…

Protein similarity searches are a routine job for molecular biologists where a query sequence of amino acids needs to be compared and ranked against an ever-growing database of proteins. All available algorithms in this field can be grouped…

Motivation: Bulk RNA-Seq is a widely used method for studying gene expression across a variety of contexts. The significance of RNA-Seq studies has grown with the advent of high-throughput sequencing technologies. Computational methods have…

We introduce and formalize the Synthetic Dataset Quality Estimation (SynQuE) problem: ranking synthetic datasets by their expected real-world task performance using only limited unannotated real data. This addresses a critical and open…

While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims…

Data and pipeline parallelism are key strategies for scaling neural network training across distributed devices, but their high communication cost necessitates co-located computing clusters with fast interconnects, limiting their…

We present pySecDec, a new version of the program SecDec, which performs the factorisation of dimensionally regulated poles in parametric integrals, and the subsequent numerical evaluation of the finite coefficients. The algebraic part of…

De novo genome assembly is challenging in highly repetitive regions; however, reference-guided assemblers often suffer from bias. We propose a framework for pangenome-guided sequence assembly, which can resolve short-read data in complex…

The recently proposed Sequence-to-Sequence (seq2seq) framework advocates replacing complex data processing pipelines, such as an entire automatic speech recognition system, with a single neural network trained in an end-to-end fashion. In…

Protein language models often take into consideration the alignment between a protein sequence and its textual description. However, they do not take structural information into consideration. Traditional methods treat sequence and…

A wide range of optimization problems arising in machine learning can be solved by gradient descent algorithms, and a central question in this area is how to efficiently compress a large-scale dataset so as to reduce the computational…

Single cell combinatorial indexing RNA sequencing (sci-RNA-seq) is a powerful method for recovering gene expression data from an exponentially scalable number of individual cells or nuclei. However, sci-RNA-seq is a complex protocol that…

Nanopore sequencing technologies continue to advance rapidly, offering critical benefits such as real-time analysis, the ability to sequence extremely long DNA fragments (up to millions of bases in a single read), and the option to…

In this paper, we propose a new optimization framework, the layer separation (LySep) model, to improve the deep learning-based methods in solving partial differential equations. Due to the highly non-convex nature of the loss function in…

Speculative decoding is an effective and lossless method for Large Language Model (LLM) inference acceleration. It employs a smaller model to generate a draft token sequence, which is then verified by the original base model. In multi-GPU…

At the core of high throughput DNA sequencing platforms lies a bio-physical surface process that results in a random geometry of clusters of homogenous short DNA fragments typically hundreds of base pairs long - bridge amplification. The…

This paper focuses on pattern matching in the DNA sequence. It was inspired by a previously reported method that proposes encoding both pattern and sequence using prime numbers. Although fast, the method is limited to rather small pattern…

Recent advances in molecular biology allow the quantification of the transcriptome and scoring transcripts as differentially or equally expressed between two biological conditions. Although these two tasks are closely linked, the available…

The transition from sequential to parallel computing is essential for modern high-performance applications but is hindered by the steep learning curve of concurrent programming. This challenge is magnified for irregular data structures…

Deep learning approaches achieve state-of-the-art performance for classifying radiology images, but rely on large labelled datasets that require resource-intensive annotation by specialists. Both semi-supervised learning and active learning…