相关论文: Generating Digital Twins with Multiple Sclerosis U…

Multiple Sclerosis (MS) is a chronic disease characterized by progressive or alternate impairment of neurological functions (motor, sensory, visual, and cognitive). Predicting disease progression with a probabilistic and time-dependent…

Restricted Boltzmann machines (RBMs) are a powerful class of generative models, but their training requires computing a gradient that, unlike supervised backpropagation on typical loss functions, is notoriously difficult even to…

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system, characterized by the appearance of focal lesions in the white and gray matter that topographically correlate with an individual…

Access to real-world healthcare data is limited by stringent privacy regulations and data imbalances, hindering advancements in research and clinical applications. Synthetic data presents a promising solution, yet existing methods often…

This work presents a probabilistic digital twin framework for response prediction in dynamical systems governed by misspecified physics. The approach integrates Gaussian Process Latent Force Models (GPLFM) and Bayesian Neural Networks…

Lifelong machine learning (LML) is an area of machine learning research concerned with human-like persistent and cumulative nature of learning. LML system's objective is consolidating new information into an existing machine learning model…

Restricted Boltzmann machines (RBM) are generative models capable to learn data with a rich underlying structure. We study the teacher-student setting where a student RBM learns structured data generated by a teacher RBM. The amount of…

The recent increase in morbidity is primarily due to chronic diseases including Diabetes, Heart disease, Lung cancer, and brain tumours. The results for patients can be improved, and the financial burden on the healthcare system can be…

Federated techniques such as federated learning and federated analysis have emerged as a powerful paradigm for enabling multi-center research on sensitive clinical data while preserving patient privacy. In this study, we introduce a…

Single-arm trials are an important study design for evaluating drug efficacy and safety without enrolling patients into a control arm. Although they do not provide the gold-standard evidence of randomized controlled trials, they are…

Restricted Boltzmann Machines (RBMs) are general unsupervised learning devices to ascertain generative models of data distributions. RBMs are often trained using the Contrastive Divergence learning algorithm (CD), an approximation to the…

Comorbid chronic conditions are common among people with type 2 diabetes. We developed an Artificial Intelligence algorithm, based on Reinforcement Learning (RL), for personalized diabetes and multi-morbidity management with strong…

Major depressive disorder (MDD) is a heterogeneous condition; multiple underlying neurobiological substrates could be associated with treatment response variability. Understanding the sources of this variability and predicting outcomes has…

Restricted Boltzmann Machine (RBM) is a particular type of random neural network models modeling vector data based on the assumption of Bernoulli distribution. For multi-dimensional and non-binary data, it is necessary to vectorize and…

Estimation of the large $Q$-matrix in Cognitive Diagnosis Models (CDMs) with many items and latent attributes from observational data has been a huge challenge due to its high computational cost. Borrowing ideas from deep learning…

Restricted Boltzmann machines (RBMs) are powerful machine learning models, but learning and some kinds of inference in the model require sampling-based approximations, which, in classical digital computers, are implemented using expensive…

The novel data analytical platform General Effect Modelling (GEM), is an umbrella platform covering different data analytical methods that handle data with multiple design variables (or pseudo design variables) and multivariate responses.…

The current multiple sclerosis (MS) diagnostic criteria lack specificity, and this may lead to misdiagnosis, which remains an issue in present-day clinical practice. In addition, conventional biomarkers only moderately correlate with MS…

Repetitive Transcranial Magnetic Stimulation (rTMS) is a well-supported, evidence-based treatment for depression. However, patterns of response to this treatment are inconsistent. Emerging evidence suggests that artificial intelligence can…

In this paper, we introduce novel Twin Parametric Margin Support Vector Machine (TPMSVM) models designed to address multiclass classification tasks under feature uncertainty. To handle data perturbations, we construct bounded-by-norm…