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Current 3D photoacoustic tomography (PAT) systems offer either high image quality or high frame rates but are not able to deliver high spatial and temporal resolution simultaneously, which limits their ability to image dynamic processes in…
Photoacoustic tomography is a contrast agent-free imaging technique capable of visualizing blood vessels and tumor-associated vascularization in breast tissue. While sophisticated breast imaging systems have been recently developed, there…
Several centimeters below the skin lie multiple biomarkers, such as glucose, oxygenation, and blood flow. Monitoring these biomarkers regularly and in a non-invasive manner would enable early insight into metabolic status and vascular…
Photoacoustic imaging (PAI) uniquely combines the advantages of optical contrast with deep tissue penetration capability of acoustic waves, enabling imaging at depths of several centimeters. Conventional photoacoustic imaging methods have…
Particle Size Analysis (PSA) is an important process carried out in a number of industries, which can significantly influence the properties of the final product. A ubiquitous instrument for this purpose is the Optical Microscope (OM).…
Recently we demonstrated an integrated photoacoustic (PA) and ultrasound (PAUS) system using a kHz-rate wavelength-tunable laser and a swept-beam delivery approach. It irradiates a medium using a narrow laser beam sweeping at high…
Hyperspectral optoacoustic microscopy (OAM) enables obtaining images with label-free biomolecular contrast, offering excellent perspectives as a diagnostic tool to assess freshly excised and unprocessed tissues. However, time-consuming…
Limited-view artefacts are commonly present in optoacoustic tomography images, mainly due to practical geometrical and physical constraints imposed by the imaging systems as well as limited light penetration into large optically opaque…
We report a novel microscopy platform, termed Multi-Aperture Fourier ptychographic microscopy (MA-FPM), capable of realizing gigapixel complex field images with large data acquisition bandwidths - in gigapixels per second. MA-FPM is a…
Objective Positron emission tomography (PET) allows imaging of patho-physiological information as a form of rate constants from a dynamic image. The rate constant image(s) may be affected from noise on the dynamic image. We introduced an…
As a hybrid imaging technology, photoacoustic microscopy (PAM) imaging suffers from noise due to the maximum permissible exposure of laser intensity, attenuation of ultrasound in the tissue, and the inherent noise of the transducer.…
Focusing light into opaque random or scattering media such as biological tissue is a much sought-after goal for biomedical applications such as photodynamic therapy, optical manipulation, and photostimulation. However, focusing with…
We have designed, constructed and optimized a novel cell for micro photoacoustic (microPA) spectroscopy (microPAS) as part of a collaboration between the Canadian Light Source and Natural Resources Canada. The cell allows inspection of…
Photoacoustic tomography (PAT) is an emerging imaging modality that aims at measuring the high-contrast optical properties of tissues by means of high-resolution ultrasonic measurements. The interaction between these two types of waves is…
Pan-sharpening involves reconstructing missing high-frequency information in multi-spectral images with low spatial resolution, using a higher-resolution panchromatic image as guidance. Although the inborn connection with frequency domain,…
Imaging of biological cells and tissues often relies on fluorescent labels, which offer high contrast with molecular specificity. The use of exogenous labeling agents, however, may alter the normal physiology of the bio-specimens.…
Fetal ultrasound standard plane classification is essential for reliable prenatal diagnosis but faces inherent challenges, including low tissue contrast, boundary ambiguity, and operator-dependent image quality variations. To overcome these…
Current optoacoustic microscopy configurations often have narrow focal ranges that limit their use for fast volumetric imaging applications. Here, the focal range of optoacoustic microscopes is extended by matching the elongated optical…
Atomic Force Microscopy (AFM) allows to reconstruct the topography of surface with a resolution in the nanometer range. The exceptional resolution attainable with the AFM makes this instrument a key tool in nanoscience and technology. The…
Extended depth of focus (EDOF) optics can enable lower complexity optical imaging systems when compared to active focusing solutions. With existing EDOF optics, however, it is difficult to achieve high resolution and high collection…