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Hybrid quantum mechanics / molecular mechanics (QM/MM) models successfully describe the properties of biological macromolecules. However, most QM/MM methodologies are constrained to unrealistic gas phase models, thus limiting their…

化学物理 · 物理学 2022-11-08 Simone Bonfrate , Nicolas Ferré , Miquel , Huix-Rotllant

Analytic first and second derivatives of the energy are developed for the fragment molecular orbital method interfaced with molecular mechanics in the electrostatic embedding scheme at the level of Hartree-Fock and density functional…

化学物理 · 物理学 2020-05-19 Hiroya Nakata , Dmitri G. Fedorov

Electrostatic potential fitting method (ESPF) is a powerful way of defining atomic charges derived from quantum density matrices fitted to reproduce a quantum mechanical charge distribution in the presence of an external electrostatic…

化学物理 · 物理学 2020-11-20 Miquel Huix-Rotllant , Nicolas Ferré

Conventional quantum chemical solvation theories are based on the mean-field embedding approximation. That is, the electronic wavefunction is calculated in the presence of the mean field of the environment. In this paper a direct quantum…

化学物理 · 物理学 2009-11-13 Takeshi Yamamoto

Estimating vibrational entropy is a significant challenge in thermodynamics and statistical mechanics due to its reliance on quantum mechanical properties. This paper introduces a quantum algorithm designed to estimate vibrational entropy…

量子物理 · 物理学 2025-11-25 Shangjie Guo , Corneliu Buda , Nathan Wiebe

We introduce and discuss a hybrid quantum-mechanics molecular-mechanics (QM-MM) approach for Car-Parrinello DFT simulations with pseudopotentials and planewaves basis, designed for the treatment of periodic systems. In this implementation…

材料科学 · 物理学 2016-07-20 Diego Hunt , Veronica M. Sanchez , Damian A. Scherlis

The maturation of analytical derivative theory over the past few decades has enabled classical electronic structure theory to provide accurate and efficient predictions of a wide variety of observable properties. However, classical…

量子物理 · 物理学 2019-06-21 Robert M. Parrish , Edward G. Hohenstein , Peter L. McMahon , Todd J. Martinez

The quantum algorithms for Monte Carlo integration (QMCI), which are based on quantum amplitude estimation (QAE), speed up expected value calculation compared with classical counterparts, and have been widely investigated along with their…

量子物理 · 物理学 2021-11-23 Koichi Miyamoto

Valence excitation spectra are computed for all deep-center silicon-vacancy defect types in 3C, 4H, and 6H silicon carbide (SiC) and comparisons are made with literature photoluminescence measurements. Nuclear geometries surrounding the…

化学物理 · 物理学 2018-03-14 Jesse J. Lutz , Xiaofeng F. Duan , Larry W. Burggraf

Quantum embedding is an appealing route to fragment a large interacting quantum system into several smaller auxiliary `cluster' problems to exploit the locality of the correlated physics. In this work we critically review approaches to…

强关联电子 · 物理学 2023-07-19 Max Nusspickel , Basil Ibrahim , George H. Booth

Molecular dynamics simulations are a central computational methodology in materials design for relating atomic composition to mechanical properties. However, simulating materials with atomic-level resolution on a macroscopic scale is…

The last several decades have seen significant advances in the theoretical modeling of materials within the fields of solid-state physics and materials science, but many methods commonly applied to this problem struggle to capture strong…

强关联电子 · 物理学 2025-04-07 Anna O. Schouten , Simon Ewing , David A. Mazziotti

We present an equivariant neural network for predicting vibrational and phonon modes of molecules and periodic crystals, respectively. These predictions are made by evaluating the second derivative Hessian matrices of the learned energy…

无序系统与神经网络 · 物理学 2024-03-19 Shiang Fang , Mario Geiger , Joseph G. Checkelsky , Tess Smidt

We present an implementation of the quantum mechanics/molecular mechanics (QM/MM) method for periodic systems using GPU accelerated QM methods, a distributed multipole formulation of the electrostatics, and a pseudo-bond treatment of the…

化学物理 · 物理学 2024-11-26 Chenghan Li , Garnet Kin-Lic Chan

Mean-field molecular dynamics based on path integrals is used to approximate canonical quantum observables for particle systems consisting of nuclei and electrons. A computational bottleneck is the sampling from the Gibbs density of the…

数值分析 · 数学 2023-11-30 Xin Huang , Petr Plechac , Mattias Sandberg , Anders Szepessy

Electric charge detection by atomic force microscopy (AFM) with single- electron resolution (e-EFM) is a promising way to investigate the electronic level structure of individual quantum dots (QD). The oscillating AFM tip modulates the…

介观与纳米尺度物理 · 物理学 2017-01-10 Yoichi Miyahara , Antoine Roy-Gobeil , Peter Grutter

Efficient computation of molecular energies is an exciting application of quantum computing for quantum chemistry, but current noisy intermediate-scale quantum (NISQ) devices can only execute shallow circuits, limiting existing variational…

Despite being a fundamental tool in soft matter research, quartz crystal microbalance (QCM) analyses of discrete macromolecules in liquid so far lack a firm theoretical basis. Currently, acoustic signals are qualitatively interpreted using…

软凝聚态物质 · 物理学 2022-01-25 Marc Meléndez Schofield , Rafael Delgado Buscalioni

Numerous molecular systems, including solutions, proteins, and composite materials, can be modeled using mixed-resolution representations, of which the quantum mechanics/molecular mechanics (QM/MM) approach has become the most widely used.…

化学物理 · 物理学 2018-01-17 Anton V. Sinitskiy , Gregory A. Voth

Accurate prediction of mRNA secondary structure is critical for understanding gene expression, translation efficiency, and advancing mRNA-based therapeutics. However, the combinatorial complexity of possible foldings, especially in long…

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