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Multiple Instance Learning (MIL) methods have succeeded remarkably in histopathology whole slide image (WSI) analysis. However, most MIL models only offer attention-based explanations that do not faithfully capture the model's decision…

计算机视觉与模式识别 · 计算机科学 2025-07-17 Susu Sun , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Publicly available collections of drug-like molecules have grown to comprise 10s of billions of possibilities in recent history due to advances in chemical synthesis. Traditional methods for identifying "hit" molecules from a large…

Multiple instance learning (MIL) has emerged as the dominant paradigm for whole slide image (WSI) analysis in computational pathology, achieving strong diagnostic performance through patch-level feature aggregation. However, existing MIL…

计算机视觉与模式识别 · 计算机科学 2025-11-17 Yiran Song , Yikai Zhang , Shuang Zhou , Guojun Xiong , Xiaofeng Yang , Nian Wang , Fenglong Ma , Rui Zhang , Mingquan Lin

Learning good representation of giga-pixel level whole slide pathology images (WSI) for downstream tasks is critical. Previous studies employ multiple instance learning (MIL) to represent WSIs as bags of sampled patches because, for most…

计算机视觉与模式识别 · 计算机科学 2022-12-01 Chunyuan Li , Xinliang Zhu , Jiawen Yao , Junzhou Huang

The success of deep learning methods in medical image segmentation tasks heavily depends on a large amount of labeled data to supervise the training. On the other hand, the annotation of biomedical images requires domain knowledge and can…

计算机视觉与模式识别 · 计算机科学 2021-09-30 Xinrong Hu , Dewen Zeng , Xiaowei Xu , Yiyu Shi

Multiple instance learning (MIL) models have achieved remarkable success in analyzing whole slide images (WSIs) for disease classification problems. However, with regard to gigapixel WSI classification problems, current MIL models are often…

计算机视觉与模式识别 · 计算机科学 2023-12-14 Ziyu Su , Mostafa Rezapour , Usama Sajjad , Metin Nafi Gurcan , Muhammad Khalid Khan Niazi

Classification of gigapixel Whole Slide Images (WSIs) is an important prediction task in the emerging area of computational pathology. There has been a surge of research in deep learning models for WSI classification with clinical…

计算机视觉与模式识别 · 计算机科学 2023-05-04 Sajid Javed , Arif Mahmood , Talha Qaiser , Naoufel Werghi , Nasir Rajpoot

In computational pathology, multiple instance learning (MIL) is widely used to circumvent the computational impasse in giga-pixel whole slide image (WSI) analysis. It usually consists of two stages: patch-level feature extraction and…

图像与视频处理 · 电气工程与系统科学 2023-09-21 Beidi Zhao , Wenlong Deng , Zi Han , Li , Chen Zhou , Zuhua Gao , Gang Wang , Xiaoxiao Li

The dynamic environment of laboratories and clinics, with streams of data arriving on a daily basis, requires regular updates of trained machine learning models for consistent performance. Continual learning is supposed to help train models…

机器学习 · 计算机科学 2025-08-12 Zahra Ebrahimi , Raheleh Salehi , Nassir Navab , Carsten Marr , Ario Sadafi

In the field of whole slide image (WSI) classification, multiple instance learning (MIL) serves as a promising approach, commonly decoupled into feature extraction and aggregation. In this paradigm, our observation reveals that…

计算机视觉与模式识别 · 计算机科学 2024-06-04 Xuenian Wang , Shanshan Shi , Renao Yan , Qiehe Sun , Lianghui Zhu , Tian Guan , Yonghong He

We propose a method to accurately obtain the ratio of tumor cells over an entire histological slide. We use deep fully convolutional neural network models trained to detect and classify cells on images of H&E-stained tissue sections.…

图像与视频处理 · 电气工程与系统科学 2021-01-29 Eric Cosatto , Kyle Gerard , Hans-Peter Graf , Maki Ogura , Tomoharu Kiyuna , Kanako C. Hatanaka , Yoshihiro Matsuno , Yutaka Hatanaka

We study a multiclass multiple instance learning (MIL) problem where the labels only suggest whether any instance of a class exists or does not exist in a training sample or example. No further information, e.g., the number of instances of…

机器学习 · 统计学 2019-03-15 Xi-Lin Li

For medical image segmentation, contrastive learning is the dominant practice to improve the quality of visual representations by contrasting semantically similar and dissimilar pairs of samples. This is enabled by the observation that…

计算机视觉与模式识别 · 计算机科学 2023-10-25 Chenyu You , Weicheng Dai , Yifei Min , Fenglin Liu , David A. Clifton , S Kevin Zhou , Lawrence Hamilton Staib , James S Duncan

Multiple instance learning (MIL) is a framework for weakly supervised classification, where labels are assigned to sets of instances, i.e., bags, rather than to individual data points. This paradigm has proven effective in tasks where…

机器学习 · 计算机科学 2026-03-03 Salome Kazeminia , Carsten Marr , Bastian Rieck

Multiple instance learning (MIL) is an effective and widely used approach for weakly supervised machine learning. In histopathology, MIL models have achieved remarkable success in tasks like tumor detection, biomarker prediction, and…

Estimating over-amplification of human epidermal growth factor receptor 2 (HER2) on invasive breast cancer (BC) is regarded as a significant predictive and prognostic marker. We propose a novel deep reinforcement learning (DRL) based model…

计算机视觉与模式识别 · 计算机科学 2019-03-27 Talha Qaiser , Nasir M. Rajpoot

Semantic segmentation, like other fields of computer vision, has seen a remarkable performance advance by the use of deep convolution neural networks. However, considering that neighboring pixels are heavily dependent on each other, both…

计算机视觉与模式识别 · 计算机科学 2017-08-08 Hyojin Park , Jisoo Jeong , Youngjoon Yoo , Nojun Kwak

The scarcity of labeled data often impedes the application of deep learning to the segmentation of medical images. Semi-supervised learning seeks to overcome this limitation by exploiting unlabeled examples in the learning process. In this…

计算机视觉与模式识别 · 计算机科学 2021-06-25 Jizong Peng , Marco Pedersoli , Christian Desrosiers

Due to the lack of quality annotation in medical imaging community, semi-supervised learning methods are highly valued in image semantic segmentation tasks. In this paper, an advanced consistency-aware pseudo-label-based self-ensembling…

图像与视频处理 · 电气工程与系统科学 2024-02-12 Ziyang Wang , Tianze Li , Jian-Qing Zheng , Baoru Huang

The diagnosis of primary liver cancers (PLCs) can be challenging, especially on biopsies and for combined hepatocellular-cholangiocarcinoma (cHCC-CCA). We automatically classified PLCs on routine-stained biopsies using a weakly supervised…