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Semi-supervised learning has substantially advanced medical image segmentation since it alleviates the heavy burden of acquiring the costly expert-examined annotations. Especially, the consistency-based approaches have attracted more…

图像与视频处理 · 电气工程与系统科学 2022-03-16 Zhe Xu , Yixin Wang , Donghuan Lu , Lequan Yu , Jiangpeng Yan , Jie Luo , Kai Ma , Yefeng Zheng , Raymond Kai-yu Tong

Histopathology-based survival modelling has two major hurdles. Firstly, a well-performing survival model has minimal clinical application if it does not contribute to the stratification of a cancer patient cohort into different risk groups,…

计算机视觉与模式识别 · 计算机科学 2021-07-12 Hassan Muhammad , Chensu Xie , Carlie S. Sigel , Michael Doukas , Lindsay Alpert , William R. Jarnagin , Amber Simpson , Thomas J. Fuchs

Training a neural network with a large labeled dataset is still a dominant paradigm in computational histopathology. However, obtaining such exhaustive manual annotations is often expensive, laborious, and prone to inter and Intra-observer…

计算机视觉与模式识别 · 计算机科学 2021-11-03 Chetan L. Srinidhi , Seung Wook Kim , Fu-Der Chen , Anne L. Martel

Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

计算机视觉与模式识别 · 计算机科学 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

In the application of Multiple Instance Learning (MIL) methods for Whole Slide Image (WSI) classification, attention mechanisms often focus on a subset of discriminative instances, which are closely linked to overfitting. To mitigate…

计算机视觉与模式识别 · 计算机科学 2024-07-08 Yunlong Zhang , Honglin Li , Yuxuan Sun , Sunyi Zheng , Chenglu Zhu , Lin Yang

Digital pathology based on whole slide images (WSIs) plays a key role in cancer diagnosis and clinical practice. Due to the high resolution of the WSI and the unavailability of patch-level annotations, WSI classification is usually…

计算机视觉与模式识别 · 计算机科学 2023-05-02 Litao Yang , Deval Mehta , Sidong Liu , Dwarikanath Mahapatra , Antonio Di Ieva , Zongyuan Ge

Convolutional Dictionary Learning (CDL) has emerged as a powerful approach for signal representation by learning translation-invariant features through convolution operations. While existing CDL methods are predominantly designed and used…

信号处理 · 电气工程与系统科学 2025-05-22 Hao Chen , Dayuan Tan

As a fundamental visual attribute, image complexity significantly influences both human perception and the performance of computer vision models. However, accurately assessing and quantifying image complexity remains a challenging task. (1)…

计算机视觉与模式识别 · 计算机科学 2025-04-28 Shipeng Liu , Liang Zhao , Dengfeng Chen

Multi-Instance Learning (MIL) is pivotal for analyzing complex, weakly labeled datasets, such as whole-slide images (WSIs) in computational pathology, where bags comprise unordered collections of instances with sparse diagnostic relevance.…

计算机视觉与模式识别 · 计算机科学 2025-09-16 Yuedi Zhang , Zhixiang Xia , Guosheng Yin , Bin Liu

This paper presents a simple yet effective two-stage framework for semi-supervised medical image segmentation. Unlike prior state-of-the-art semi-supervised segmentation methods that predominantly rely on pseudo supervision directly on…

计算机视觉与模式识别 · 计算机科学 2023-08-01 Huimin Wu , Xiaomeng Li , Kwang-Ting Cheng

Semantic segmentation of various tissue and nuclei types in histology images is fundamental to many downstream tasks in the area of computational pathology (CPath). In recent years, Deep Learning (DL) methods have been shown to perform well…

计算机视觉与模式识别 · 计算机科学 2023-02-14 Raja Muhammad Saad Bashir , Talha Qaiser , Shan E Ahmed Raza , Nasir M. Rajpoot

Universal, transferable whole-slide image (WSI) representations are central to computational pathology. Incorporating multiple markers (e.g., immunohistochemistry, IHC) alongside H&E enriches H&E-based features with diverse, biologically…

计算机视觉与模式识别 · 计算机科学 2025-12-04 Yizhi Zhang , Lei Fan , Zhulin Tao , Donglin Di , Yang Song , Sidong Liu , Cong Cong

Introducing interpretability and reasoning into Multiple Instance Learning (MIL) methods for Whole Slide Image (WSI) analysis is challenging, given the complexity of gigapixel slides. Traditionally, MIL interpretability is limited to…

计算机视觉与模式识别 · 计算机科学 2024-05-21 Saarthak Kapse , Pushpak Pati , Srijan Das , Jingwei Zhang , Chao Chen , Maria Vakalopoulou , Joel Saltz , Dimitris Samaras , Rajarsi R. Gupta , Prateek Prasanna

Graph-based Multiple Instance Learning (MIL) is widely used in survival analysis with Hematoxylin and Eosin (H\&E)-stained whole slide images (WSIs) due to its ability to capture topological information. However, variations in staining and…

计算机视觉与模式识别 · 计算机科学 2025-09-25 Min Cen , Zhenfeng Zhuang , Yuzhe Zhang , Min Zeng , Baptiste Magnier , Lequan Yu , Hong Zhang , Liansheng Wang

The Multiple Instance Learning (MIL) paradigm is attracting plenty of attention in medical imaging classification, where labeled data is scarce. MIL methods cast medical images as bags of instances (e.g. patches in whole slide images, or…

计算机视觉与模式识别 · 计算机科学 2025-07-22 Francisco M. Castro-Macías , Pablo Morales-Álvarez , Yunan Wu , Rafael Molina , Aggelos K. Katsaggelos

Multiple Instance Learning (MIL) has garnered widespread attention in the field of Whole Slide Image (WSI) classification as it replaces pixel-level manual annotation with diagnostic reports as labels, significantly reducing labor costs.…

图像与视频处理 · 电气工程与系统科学 2025-07-08 Tianhang Nan , Hao Quan , Yong Ding , Xingyu Li , Kai Yang , Xiaoyu Cui

In Multiple Instance learning (MIL), weak labels are provided at the bag level with only presence/absence information known. However, there is a considerable gap in performance in comparison to a fully supervised model, limiting the…

机器学习 · 计算机科学 2021-03-22 Anxiang Zhang , Ankit Shah , Bhiksha Raj

The computer-aided analysis of medical scans is a longstanding goal in the medical imaging field. Currently, deep learning has became a dominant methodology for supporting pathologists and radiologist. Deep learning algorithms have been…

机器学习 · 计算机科学 2017-12-06 Jakub M. Tomczak , Maximilian Ilse , Max Welling

This work proposes a classification approach for breast cancer histopathologic images (HI) that uses transfer learning to extract features from HI using an Inception-v3 CNN pre-trained with ImageNet dataset. We also use transfer learning on…

计算机视觉与模式识别 · 计算机科学 2019-04-17 Jonathan de Matos , Alceu de S. Britto , Luiz E. S. Oliveira , Alessandro L. Koerich

Definitive cancer diagnosis and management depend upon the extraction of information from microscopy images by pathologists. These images contain complex information requiring time-consuming expert human interpretation that is prone to…