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DNA sequence alignment involves assigning short DNA reads to the most probable locations on an extensive reference genome. This process is crucial for various genomic analyses, including variant calling, transcriptomics, and epigenomics.…

Motivation: High-coverage sequencing data have significant, yet hard to exploit, redundancy. Most FASTQ compressors cannot efficiently compress the DNA stream of large datasets, since the redundancy between overlapping reads cannot be…

数据结构与算法 · 计算机科学 2014-09-19 Szymon Grabowski , Sebastian Deorowicz , Łukasz Roguski

This paper presents a novel hardware system for high-speed, event-sparse sampling-based electronic skin (e-skin)that integrates sensing and neuromorphic computing. The system is built around a 16x16 piezoresistive tactile array with front…

神经与进化计算 · 计算机科学 2026-03-12 Gaishan Li , Zhengnan Fu , Anubhab Tripathi , Junyi Yang , Arindam Basu

Homomorphic encryption is a sophisticated encryption technique that allows computations on encrypted data to be done without the requirement for decryption. This trait makes homomorphic encryption appropriate for safe computation in…

密码学与安全 · 计算机科学 2023-05-11 Nimish Jain , Aswani Kumar Cherukuri

Clinical trials are essential for drug development but often suffer from expensive, inaccurate and insufficient patient recruitment. The core problem of patient-trial matching is to find qualified patients for a trial, where patient…

人工智能 · 计算机科学 2021-04-13 Xingyao Zhang , Cao Xiao , Lucas M. Glass , Jimeng Sun

Feature engineering remains a major bottleneck when creating predictive systems from electronic medical records. At present, an important missing element is detecting predictive regular clinical motifs from irregular episodic records. We…

机器学习 · 统计学 2016-07-27 Phuoc Nguyen , Truyen Tran , Nilmini Wickramasinghe , Svetha Venkatesh

Preserving the privacy and security of big data in the context of cloud computing, while maintaining a certain level of efficiency of its processing remains to be a subject, open for improvement. One of the most popular applications…

密码学与安全 · 计算机科学 2022-02-02 Ş. S. Mağara , C. Yıldırım , F. Yaman , B. Dilekoğlu , F. R. Tutaş , E. Öztürk , K. Kaya , Ö. Taştan , E. Savaş

Typical EEG-based BCI applications require the computation of complex functions over the noisy EEG channels to be carried out in an efficient way. Deep learning algorithms are capable of learning flexible nonlinear functions directly from…

机器学习 · 计算机科学 2020-09-01 Andrea Valenti , Michele Barsotti , Raffaello Brondi , Davide Bacciu , Luca Ascari

Text embedding models enable semantic search, powering several NLP applications like Retrieval Augmented Generation by efficient information retrieval (IR). However, text embedding models are commonly studied in scenarios where the training…

信息检索 · 计算机科学 2025-10-07 Dipam Goswami , Liying Wang , Bartłomiej Twardowski , Joost van de Weijer

Order-preserving pattern matching was introduced recently but it has already attracted much attention. Given a reference sequence and a pattern, we want to locate all substrings of the reference sequence whose elements have the same…

数据结构与算法 · 计算机科学 2018-12-11 Gianni Decaroli , Travis Gagie , Giovanni Manzini

Compressed inverted indices in use today are based on the idea of gap compression: documents pointers are stored in increasing order, and the gaps between successive document pointers are stored using suitable codes which represent smaller…

信息检索 · 计算机科学 2012-06-20 Sebastiano Vigna

Electronic Health Records (EHR) are crucial for the success of digital healthcare, with a focus on putting consumers at the center of this transformation. However, the digitalization of healthcare records brings along security and privacy…

机器学习 · 计算机科学 2024-10-07 Vinaytosh Mishra , Kishu Gupta , Deepika Saxena , Ashutosh Kumar Singh

Large scale deep learning model, such as modern language models and diffusion architectures, have revolutionized applications ranging from natural language processing to computer vision. However, their deployment in distributed or…

Searchable symmetric encryption (SSE) has been used to protect the confidentiality of genomic data while providing substring search and range queries on a sequence of genomic data, but it has not been studied for protecting single…

密码学与安全 · 计算机科学 2021-07-01 Sara Jafarbeiki , Amin Sakzad , Shabnam Kasra Kermanshahi , Raj Gaire , Ron Steinfeld , Shangqi Lai , Gad Abraham

Cloud computing is emerging as a revolutionary computing paradigm which pro-vides a flexible and economic strategy for data management and resource sharing. Security and privacy become major concerns in the cloud scenario, for which…

信息检索 · 计算机科学 2017-09-01 Ruihui Zhao , Mizuho Iwaihara

The rapid advance of DNA sequencing technologies has yielded databases of thousands of genomes. To search and index these databases effectively, it is important that we take advantage of the similarity between those genomes. Several authors…

数据结构与算法 · 计算机科学 2014-12-05 Travis Gagie , Simon J. Puglisi

Electronic Health Records (EHRs) are pivotal in clinical practices, yet their retrieval remains a challenge mainly due to semantic gap issues. Recent advancements in dense retrieval offer promising solutions but existing models, both…

信息检索 · 计算机科学 2025-07-25 Zhengyun Zhao , Huaiyuan Ying , Yue Zhong , Sheng Yu

This work presents Homomorphic Encryption Intermediate Representation (HEIR), a unified approach to building homomorphic encryption (HE) compilers. HEIR aims to support all mainstream techniques in homomorphic encryption, integrate with all…

Genome sequencing technology has advanced at a rapid pace and it is now possible to generate highly-detailed genotypes inexpensively. The collection and analysis of such data has the potential to support various applications, including…

Biomarker discovery is vital in advancing personalized medicine, offering insights into disease diagnosis, prognosis, and therapeutic efficacy. Traditionally, the identification and validation of biomarkers heavily depend on extensive…

机器学习 · 计算机科学 2024-09-25 Wangyang Ying , Dongjie Wang , Xuanming Hu , Ji Qiu , Jin Park , Yanjie Fu