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We investigate the effect of the proportional hazards assumption on prognostic and predictive models of the survival time of patients suffering from amyotrophic lateral sclerosis (ALS). We theoretically compare the underlying model…

统计方法学 · 统计学 2019-10-22 Natalia Korepanova , Heidi Seibold , Verena Steffen , Torsten Hothorn

Analysis of 2 by 2 tables and two-sample survival data has been widely used. Exact calculation is computational intractable for conditional likelihood inference in odds ratio models with large marginals in 2 by 2 tables, or partial…

统计方法学 · 统计学 2019-11-26 Zhiqiang Tan

While analysing time-to-event data, it is possible that a certain fraction of subjects will never experience the event of interest and they are said to be cured. When this feature of survival models is taken into account, the models are…

统计方法学 · 统计学 2020-01-27 Khandoker Akib Mohammad , Yuichi Hirose , Budhi Surya , Yuan Yao

Proportional mean residual life model is studied for analysing survival data from the case-cohort design. To simultaneously estimate the regression parameters and the baseline mean residual life function, weighted estimating equations based…

统计理论 · 数学 2019-01-18 Huijuan Ma , Jianhua Shi , Yong Zhou

A simple yet effective way of modeling survival data with cure fraction is by considering Box-Cox transformation cure model (BCTM) that unifies mixture and promotion time cure models. In this article, we numerically study the statistical…

统计方法学 · 统计学 2023-10-25 Suvra Pal , Sandip Barui

This paper explores foundational and applied aspects of survival analysis, using fall risk assessment as a case study. It revisits key time-related probability distributions and statistical methods, including logistic regression, Poisson…

机器学习 · 计算机科学 2025-01-07 Tianhua Chen

In this article, we consider models for time-to-event data obtained from experiments in which stress levels are altered at intermediate stages during the observation period. These experiments, known as step-stress tests, belong to the…

应用统计 · 统计学 2018-07-04 Nandini Kannan , Debasis Kundu

Survival analysis is a statistical framework for modeling time-to-event data. It plays a pivotal role in medicine, reliability engineering, and social science research, where understanding event dynamics even with few data samples is…

机器学习 · 计算机科学 2026-02-03 Alberto Archetti , Eugenio Lomurno , Diego Piccinotti , Matteo Matteucci

In this paper, we make an experimental comparison of semi-parametric (Cox proportional hazards model, Aalen's additive regression model), parametric (Weibull AFT model), and machine learning models (Random Survival Forest, Gradient Boosting…

机器学习 · 计算机科学 2020-03-20 Camila Fernandez , Chung Shue Chen , Pierre Gaillard , Alonso Silva

The mixture cure model for analyzing survival data is characterized by the assumption that the population under study is divided into a group of subjects who will experience the event of interest over some finite time horizon and another…

统计方法学 · 统计学 2022-03-30 Oswaldo Gressani , Christel Faes , Niel Hens

Several researchers have described two-part models with patient-specific stochastic processes for analysing longitudinal semicontinuous data. In theory, such models can offer greater flexibility than the standard two-part model with…

应用统计 · 统计学 2017-03-28 Sean Yiu , Brian Tom

Semi-Markov models are widely used for survival analysis and reliability analysis. In general, there are two competing parameterizations and each entails its own interpretation and inference properties. On the one hand, a semi-Markov…

统计方法学 · 统计学 2021-01-01 Azam Asanjarani , Benoit Liquet , Yoni Nazarathy

In this paper we introduce a new lifetime distribution by compounding exponential and Poisson-Lindley distributions, named exponential Poisson-Lindley distribution. Several properties are derived, such as density, failure rate, mean…

统计方法学 · 统计学 2013-02-20 Wagner Barreto-Souza , Hassan S. Bakouch

In this article, we develop nonparametric inference methods for comparing survival data across two samples, which are beneficial for clinical trials of novel cancer therapies where long-term survival is a critical outcome. These therapies,…

统计方法学 · 统计学 2024-09-05 Yi-Cheng Tai , Weijing Wang , Martin T. Wells

The robust Poisson method is becoming increasingly popular when estimating the association of exposures with a binary outcome. Unlike the logistic regression model, the robust Poisson method yields results that can be interpreted as risk or…

统计方法学 · 统计学 2022-09-14 Denis Talbot , Miceline Mésidor , Yohann Chiu , Marc Simard , Caroline Sirois

Maximum approximate Bernstein likelihood estimates of the baseline density function and the regression coefficients in the proportional hazard regression models based on interval-censored event time data are proposed. This results in not…

统计方法学 · 统计学 2020-12-25 Zhong Guan

Survival analysis often relies on Cox models, assuming both linearity and proportional hazards (PH). This study evaluates machine and deep learning methods that relax these constraints, comparing their performance with penalized Cox models…

机器学习 · 计算机科学 2025-10-21 Ivan Rossi , Flavio Sartori , Cesare Rollo , Giovanni Birolo , Piero Fariselli , Tiziana Sanavia

Accelerated life tests (ALTs) play a crucial role in reliability analyses, providing lifetime estimates of highly reliable products. Among ALTs, step-stress design increases the stress level at predefined times, while maintaining a constant…

统计理论 · 数学 2024-02-12 Narayanaswamy Balakrishnan , María Jaenada , Leandro Pardo

Transfer learning is beneficial for survival analysis, especially when the target study has a limited number of events. However, existing transfer learning methods rely on the restrictive assumption that the target and source studies share…

统计方法学 · 统计学 2026-03-13 Yu Gu , Donglin Zeng , D. Y. Lin

The paper offers a novel unified approach to studying the accuracy of parameter estimation by the quasi likelihood method. Important features of the approach are: (1) The underlying model {is not assumed to be parametric}. (2) No conditions…

统计理论 · 数学 2009-03-11 V. Spokoiny