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Many scientific questions in biomedical, environmental, and psychological research involve understanding the effects of multiple factors on outcomes. While factorial experiments are ideal for this purpose, randomized controlled treatment…

统计方法学 · 统计学 2025-12-03 Ruoqi Yu , Peng Ding

Violations of the parallel trends assumption pose significant challenges for causal inference in difference-in-differences (DiD) studies, especially in policy evaluations where pre-treatment dynamics and external shocks may bias estimates.…

统计方法学 · 统计学 2025-08-06 Seong Woo Han , Nandita Mitra , Gary Hettinger , Arman Oganisian

Disease progression models are widely used to inform the diagnosis and treatment of many progressive diseases. However, a significant limitation of existing models is that they do not account for health disparities that can bias the…

机器学习 · 计算机科学 2025-05-01 Erica Chiang , Divya Shanmugam , Ashley N. Beecy , Gabriel Sayer , Deborah Estrin , Nikhil Garg , Emma Pierson

It is often of interest in observational studies to measure the causal effect of a treatment on time-to-event outcomes. In a medical setting, observational studies commonly involve patients who initiate medication therapy and others who do…

统计方法学 · 统计学 2019-10-07 Reagan Mozer , Mark E. Glickman

In cancer translational research, increasing effort is devoted to the study of the combined effect of two drugs when they are administered simultaneously. In this paper, we introduce a new approach to estimate the part of the effect of the…

应用统计 · 统计学 2019-09-24 Andrea Cremaschi , Arnoldo Frigessi , Kjetil Taskén , Manuela Zucknick

Motivated by the increasing use of and rapid changes in array technologies, we consider the prediction problem of fitting a linear regression relating a continuous outcome $Y$ to a large number of covariates $\mathbf {X}$, for example,…

应用统计 · 统计学 2014-01-13 Philip S. Boonstra , Bhramar Mukherjee , Jeremy M. G. Taylor

In longitudinal observational studies with time-to-event outcomes, a common objective in causal analysis is to estimate the causal survival curve under hypothetical intervention scenarios. The g-formula is a useful tool for this analysis.…

统计方法学 · 统计学 2025-04-14 Xinyuan Chen , Liangyuan Hu , Fan Li

It has historically been a challenge to perform Bayesian inference in a design-based survey context. The present paper develops a Bayesian model for sampling inference in the presence of inverse-probability weights. We use a hierarchical…

统计方法学 · 统计学 2020-06-24 Yajuan Si , Natesh S. Pillai , Andrew Gelman

Linear mixed effects models are widely used in statistical modelling. We consider a mixed effects model with Bayesian variable selection in the random effects using spike-and-slab priors and developed a variational Bayes inference scheme…

统计方法学 · 统计学 2024-08-15 M-Z. Spyropoulou , J. Hopker , J. E. Griffin

We establish concentration rates for estimation of treatment effects in experiments that incorporate prior sources of information -- such as past pilots, related studies, or expert assessments -- whose external validity is uncertain. Each…

计量经济学 · 经济学 2026-03-24 Frederico Finan , Demian Pouzo

Distributed lag models are useful in environmental epidemiology as they allow the user to investigate critical windows of exposure, defined as the time period during which exposure to a pollutant adversely affects health outcomes. Recent…

统计方法学 · 统计学 2021-08-02 Joseph Antonelli , Ander Wilson , Brent Coull

Computer Adaptive Testing (CAT) aims to accurately estimate an individual's ability using only a subset of an Item Response Theory (IRT) instrument. Many applications also require diverse item exposure across testing sessions, preventing…

统计方法学 · 统计学 2026-04-01 Tina Su , Edison Choe , Joshua C. Chang

Sensitivity Analysis is a framework to assess how conclusions drawn from missing outcome data may be vulnerable to departures from untestable underlying assumptions. We extend the E-value, a popular metric for quantifying robustness of…

统计方法学 · 统计学 2021-08-31 Wu Xue , Abbas Zaidi

Bayesian adaptive designs have gained popularity in all phases of clinical trials with numerous new developments in the past few decades. During the COVID-19 pandemic, the need to establish evidence for the effectiveness of vaccines,…

统计方法学 · 统计学 2022-03-08 Shirin Golchi

This paper proposes a robust Bayesian accelerated failure time model for censored survival data. We develop a new family of life-time distributions using a scale mixture of the generalized gamma distributions, where we propose a novel super…

统计方法学 · 统计学 2025-04-16 Yasuyuki Hamura , Takahiro Onizuka , Shintaro Hashimoto , Shonosuke Sugasawa

Motivated by the Acute Respiratory Distress Syndrome Network (ARDSNetwork) ARDS respiratory management (ARMA) trial, we developed a flexible Bayesian machine learning approach to estimate the average causal effect and heterogeneous causal…

应用统计 · 统计学 2024-10-29 Xinyuan Chen , Michael O. Harhay , Guangyu Tong , Fan Li

It is not always clear how to adjust for control data in causal inference, balancing the goals of reducing bias and variance. We show how, in a setting with repeated experiments, Bayesian hierarchical modeling yields an adaptive procedure…

统计方法学 · 统计学 2025-01-23 Andrew Gelman , Matthijs Vákár

When planning a clinical trial for a time-to-event endpoint, we require an estimated effect size and need to consider the type of effect. Usually, an effect of proportional hazards is assumed with the hazard ratio as the corresponding…

统计方法学 · 统计学 2026-03-02 Moritz Fabian Danzer , Ina Dormuth

Modern approaches to perform Bayesian variable selection rely mostly on the use of shrinkage priors. That said, an ideal shrinkage prior should be adaptive to different signal levels, ensuring that small effects are ruled out, while keeping…

统计方法学 · 统计学 2024-11-14 Santiago Marin , Bronwyn Loong , Anton H. Westveld

Nonparametric and semiparametric methods are commonly used in survival analysis to mitigate the bias due to model misspecification. However, such methods often cannot estimate upper-tail survival quantiles when a sizable proportion of the…

统计方法学 · 统计学 2019-07-19 Yifan Wang , Tian You , Martin Lysy