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There is growing interest in using machine learning (ML) to support clinical diagnosis, but most approaches rely on static, fully observed datasets and fail to reflect the sequential, resource-aware reasoning clinicians use in practice.…

人工智能 · 计算机科学 2025-11-18 Silas Ruhrberg Estévez , Nicolás Astorga , Mihaela van der Schaar

In the presence of heterogeneity between the randomized controlled trial (RCT) participants and the target population, evaluating the treatment effect solely based on the RCT often leads to biased quantification of the real-world treatment…

统计方法学 · 统计学 2022-10-05 Dasom Lee , Shu Yang , Xiaofei Wang

We consider the problem of jointly testing multiple hypotheses and estimating a random parameter of the underlying distribution. This problem is investigated in a sequential setup under mild assumptions on the underlying random process. The…

信号处理 · 电气工程与系统科学 2021-05-07 Dominik Reinhard , Michael Fauß , Abdelhak M. Zoubir

This paper considers the estimation of treatment effects in randomized experiments with complex experimental designs, including cases with interference between units. We develop a design-based estimation theory for arbitrary experimental…

计量经济学 · 经济学 2025-05-27 Haoge Chang

Clinical outcome prediction plays an important role in stroke patient management. From a machine learning point-of-view, one of the main challenges is dealing with heterogeneous data at patient admission, i.e. the image data which are…

图像与视频处理 · 电气工程与系统科学 2022-05-12 Nima Hatami , Tae-Hee Cho , Laura Mechtouff , Omer Faruk Eker , David Rousseau , Carole Frindel

Decision trees and their ensembles are endowed with a rich set of diagnostic tools for ranking and screening variables in a predictive model. Despite the widespread use of tree based variable importance measures, pinning down their…

机器学习 · 统计学 2020-12-14 Jason M. Klusowski , Peter M. Tian

Decision-making across various fields, such as medicine, heavily relies on conditional average treatment effects (CATEs). Practitioners commonly make decisions by checking whether the estimated CATE is positive, even though the…

We consider the problem of estimating the effects of a binary treatment on a continuous outcome of interest from observational data in the absence of confounding by unmeasured factors. We provide a new estimator of the population average…

统计方法学 · 统计学 2020-08-04 James Robins , Mariela Sued , Quanhong Lei-Gomez , Andrea Rotnitzky

Mixed effects (ME) models inform a vast array of problems in the physical and social sciences, and are pervasive in meta-analysis. We consider ME models where the random effects component is linear. We then develop an efficient approach for…

Stepped wedge cluster randomized trials (SW-CRTs) have become increasingly popular and are used for a variety of interventions and outcomes, often chosen for their feasibility advantages. SW-CRTs must account for time trends in the outcome…

统计方法学 · 统计学 2024-07-16 Lee Kennedy-Shaffer , Victor De Gruttola , Marc Lipsitch

Non-linear mixed effects modeling and simulation (NLME M&S) is evaluated to be used for standardization with longitudinal data in presence of confounders. Standardization is a well-known method in causal inference to correct for confounding…

统计方法学 · 统计学 2024-05-01 Christian Bartels , Martina Scauda , Neva Coello , Thomas Dumortier , Bjoern Bornkamp , Giusi Moffa

In this paper, we borrow from blind noise parameter estimation (BNPE) methodology early developed in the image processing field an original and innovative no-reference approach to estimate Digital Elevation Model (DEM) vertical error…

计算机视觉与模式识别 · 计算机科学 2018-01-25 Mykhail Uss , Benoit Vozel , Vladimir Lukin , Kacem Chehdi

We investigate a data-driven approach to constructing uncertainty sets for robust optimization problems, where the uncertain problem parameters are modeled as random variables whose joint probability distribution is not known. Relying only…

最优化与控制 · 数学 2020-09-22 Polina Alexeenko , Eilyan Bitar

Recent advances in noiseless non-adaptive group testing have led to a precise asymptotic characterization of the number of tests required for high-probability recovery in the sublinear regime $k = n^{\theta}$ (with $\theta \in (0,1)$), with…

数据结构与算法 · 计算机科学 2021-12-24 Oliver Gebhard , Max Hahn-Klimroth , Olaf Parczyk , Manuel Penschuck , Maurice Rolvien , Jonathan Scarlett , Nelvin Tan

Point identification of causal effects requires strong assumptions that are unreasonable in many practical settings. However, informative bounds on these effects can often be derived under plausible assumptions. Even when these bounds are…

统计方法学 · 统计学 2024-04-18 Julien D. Laurendeau , Aaron L. Sarvet , Mats J. Stensrud

We analyze the properties of matching estimators when there are few treated, but many control observations. We show that, under standard assumptions, the nearest neighbor matching estimator for the average treatment effect on the treated is…

计量经济学 · 经济学 2021-03-24 Bruno Ferman

Regression analyses based on transformations of cumulative incidence functions are often adopted when modeling and testing for treatment effects in clinical trial settings involving competing and semi-competing risks. Common frameworks…

统计方法学 · 统计学 2024-01-11 Alexandra Bühler , Richard J Cook , Jerald F Lawless

In randomized controlled trials without interference, regression adjustment is widely used to enhance the efficiency of treatment effect estimation. This paper extends this efficiency principle to settings with network interference, where a…

统计方法学 · 统计学 2025-02-18 Xinyuan Fan , Chenlei Leng , Weichi Wu

Spectral submanifolds (SSMs) have emerged as accurate and predictive model reduction tools for dynamical systems defined either by equations or data sets. While finite-elements (FE) models belong to the equation-based class of problems,…

动力系统 · 数学 2024-12-18 Mattia Cenedese , Jacopo Marconi , George Haller , Shobhit Jain

The use of machine learning (ML) model as digital-twins for reduced-order-modeling (ROM) in lieu of system codes has grown traction over the past few years. However, due to the complex and non-linear nature of nuclear reactor transients as…

机器学习 · 计算机科学 2022-05-24 Edward Chen , Linyu Lin , Nam T. Dinh