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Visualizing individual charges confined to molecules and observing their dynamics with high spatial resolution is a challenge for advancing various fields in science, ranging from mesoscopic physics to electron transfer events in biological…

介观与纳米尺度物理 · 物理学 2016-09-19 Tatiana Latychevskaia , Flavio Wicki , Jean-Nicolas Longchamp , Conrad Escher , Hans-Werner Fink

Modern microscopy techniques are aimed at imaging an individual molecule at atomic resolution. Here we show that low-energy electrons with kinetic energies of 50-250 eV offer a possibility of overcome the problem of radiation damage, and…

生物物理 · 物理学 2013-05-09 Tatiana Latychevskaia , Jean-Nicolas Longchamp , Conrad Escher , Hans-Werner Fink

Charge migration along DNA molecules has attracted scientific interest for over half a century. Reports on possible high rates of charge transfer between donor and acceptor through the DNA, obtained in the last decade from solution…

材料科学 · 物理学 2009-11-10 Danny Porath , Gianaurelio Cuniberti , Rosa Di Felice

Radiation damage is considered to be the major problem that still prevents imaging an individual biological molecule for structural analysis. So far, all known mapping techniques using sufficient short wave-length radiation, be it X-rays or…

生物物理 · 物理学 2010-10-28 Matthias Germann , Tatiana Latychevskaia , Conrad Escher , Hans-Werner Fink

Coherent low-energy electrons have been demonstrated as a practical tool for imaging individual macromolecules and two-dimensional (2D) crystals. Low-energy electrons exhibit unique properties: low radiation damage to biological molecules…

仪器与探测器 · 物理学 2025-09-29 Tatiana Latychevskaia

Transmission electron microscopy at very low energy is a promising way to avoid damaging delicate biological samples with the incident electrons, a known problem in conventional transmission electron microscopy. For imaging in the 0-30 eV…

材料科学 · 物理学 2020-09-22 Peter S. Neu , Daniël Geelen , Aniket Thete , Rudolf M. Tromp , Sense Jan van der Molen

While imaging individual atoms can routinely be achieved in high resolution transmission electron microscopy, visualizing the potential distribution of individually charged adsorbates leading to a phase shift of the probing electron wave is…

介观与纳米尺度物理 · 物理学 2017-08-08 Tatiana Latychevskaia , Flavio Wicki , Conrad Escher , Hans-Werner Fink

The question of whether DNA conducts electric charges is intriguing to physicists and biologists alike. The suggestion that electron transfer/transport in DNA might be biologically important has triggered a series of experimental and…

无序系统与神经网络 · 物理学 2020-05-04 H. Wang , R. Marsh , J. P. Lewis , R. A. Roemer

Phase imaging in electron microscopy is sensitive to the local potential, including charge redistribution from bonding. We demonstrate that electron ptychography provides the necessary sensitivity to detect this subtle effect by directly…

How quantum electron and nuclei motions affect biomolecular chemical reactions remains a central challengeable question at the interface of quantum chemistry and biology. Ultrafast charge migration in deoxyribonucleic acid (DNA) has long…

化学物理 · 物理学 2025-12-30 Nikolay V. Golubev , Mohammed Th. Hassan

Modeling charge transport in DNA is essential to understand and control the electrical properties and develop DNA-based nanoelectronics. DNA is a fluctuating molecule that exists in a solvent environment, which makes the electron…

生物物理 · 物理学 2023-10-05 Hashem Mohammad , M. P. Anantram

We study the electronic properties of DNA by way of a tight-binding model applied to four particular DNA sequences. The charge transfer properties are presented in terms of localisation lengths, crudely speaking the length over which…

基因组学 · 定量生物学 2007-05-23 Daphne Klotsa , Rudolf A. Roemer , Matthew S. Turner

Imaging single proteins has been a long-standing ambition for advancing various fields in natural science, as for instance structural biology, biophysics and molecular nanotechnology. In particular, revealing the distinct conformations of…

The electrical properties of DNA molecules are investigated by charge injection and electric force microscopy experiments. Prior to injection, DNA molecules exhibit a weak positively charged state. We probe the electrical behaviour of DNA…

材料科学 · 物理学 2009-11-10 Thomas Heim , Thierry Melin , Dominique Deresmes , Dominique Vuillaume

The purpose of this project is to investigate the use of charge couple devices (CCDs) to detect electrons directly. This can be done in transmission electron microscopy (TEM) for electrons over 100 KeV, but for space plasma instruments,…

仪器与探测器 · 物理学 2015-10-28 S. R. Mirfayzi

Charge diffusion through desoxyribonucleic acid (DNA) is a physico-chemical phenomenon that on the one hand is being explored for technological purposes, on the other hand is applied by nature for various informational processes in life.…

生物物理 · 物理学 2024-07-22 Mirko Rossini , Ole Ammerpohl , Reiner Siebert , Joachim Ankerhold

Measuring the electrophoretic mobility of molecules is a powerful experimental approach for investigating biomolecular processes. A frequent challenge in the context of single-particle measurements is throughput, limiting the obtainable…

光学 · 物理学 2021-07-26 Xuanhui Meng , Philipp Kukura , Sanli Faez

The interaction between free electrons and nanoscale optical fields has emerged as a unique platform to investigate ultrafast processes in matter and explore fundamental quantum phenomena. In particular, optically modulated electrons are…

介观与纳米尺度物理 · 物理学 2024-11-07 Adamantios P. Synanidis , P. A. D. Gonçalves , Claus Ropers , F. Javier García de Abajo

The rapid progress in the field of molecular electronics has led to an increasing interest on DNA oligomers as possible components of electronic circuits at the nanoscale. For this, however, an understanding of charge transfer and transport…

软凝聚态物质 · 物理学 2007-05-23 R. Gutierrez , G. Cuniberti

In solution, DNA is a highly charged macromolecule which bears a unit of negative charge on each phosphate of its sugar-phosphate backbone. Although partially compensated by counterions adsorbed at or condensed near it, DNA still produces a…

软凝聚态物质 · 物理学 2024-03-11 Jonathan G. Hedley , Kush Coshic , Aleksei Aksimentiev , Alexei A. Kornyshev
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