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Diffusion-weighted magnetic resonance imaging (dMRI) allows non-invasive investigation of whole-brain connectivity, which can potentially help to reveal the brain's global network architecture and abnormalities involved in neurological and…

Time-dependent diffusion MRI (dMRI) with single diffusion encoding (SDE) probes water dynamics in biological tissues, but signal interpretation depends on microstructure. While prior work focused on restricted/hindered diffusion and…

医学物理 · 物理学 2025-06-26 Kadir Şimşek , Arthur Chakwizira , Markus Nilsson , Marco Palombo

Quantitative magnetization transfer (qMT) imaging provides myelin-sensitive biomarkers, such as the pool size ratio (PSR), which is valuable for multiple sclerosis (MS) assessment. However, qMT requires specialized 20-30 minute scans. We…

图像与视频处理 · 电气工程与系统科学 2025-11-27 Jiacheng Wang , Hao Li , Xing Yao , Ahmad Toubasi , Taegan Vinarsky , Caroline Gheen , Joy Derwenskus , Chaoyang Jin , Richard Dortch , Junzhong Xu , Francesca Bagnato , Ipek Oguz

Understanding how the brain responds to sensory inputs is challenging: brain recordings are partial, noisy, and high dimensional; they vary across sessions and subjects and they capture highly nonlinear dynamics. These challenges have led…

神经元与认知 · 定量生物学 2022-10-03 Omar Chehab , Alexandre Defossez , Jean-Christophe Loiseau , Alexandre Gramfort , Jean-Remi King

Diffusion models have become a leading framework in generative modeling, yet their theoretical understanding -- especially for high-dimensional data concentrated on low-dimensional structures -- remains incomplete. This paper investigates…

机器学习 · 计算机科学 2026-04-29 Zixuan Zhang , Kaixuan Huang , Tuo Zhao , Mengdi Wang , Minshuo Chen

This article introduces a new methodology for reconstructing the white matter fiber pathways of brain in diffusion MRI. Usually, the signal intensity values will be lesser in the direction of higher diffusivity. The proposed approach picks…

神经元与认知 · 定量生物学 2022-07-26 Ashishi Puri , Sanjeev Kumar

Brain midline shift (MLS) is one of the most critical factors to be considered for clinical diagnosis and treatment decision-making for intracranial hemorrhage. Existing computational methods on MLS quantification not only require intensive…

计算机视觉与模式识别 · 计算机科学 2023-01-03 Shizhan Gong , Cheng Chen , Yuqi Gong , Nga Yan Chan , Wenao Ma , Calvin Hoi-Kwan Mak , Jill Abrigo , Qi Dou

Quantifying muscle tissue properties is crucial for understanding pathophysiological changes occurring in skeletal muscle (SM). In particular, T2 relaxation and diffusion MRI (dMRI) are promising techniques. However, typical methods measure…

We propose a novel approach to denoising diffusion magnetic resonance images (dMRI) using convolutional neural networks, that exploits the benefits of data acquired at multiple b-values to offset the need for many redundant observations.…

图像与视频处理 · 电气工程与系统科学 2024-10-23 Jakub Jurek , Andrzej Materka , Kamil Ludwisiak , Agata Majos , Filip Szczepankiewicz

Monitoring diseases that affect the brain's structural integrity requires automated analysis of magnetic resonance (MR) images, e.g., for the evaluation of volumetric changes. However, many of the evaluation tools are optimized for…

Development of successful therapies for neurological disorders depends on our ability to diagnose and monitor the progression of underlying pathologies at the cellular level. Physics and physiology limit the resolution of human MRI to…

生物物理 · 物理学 2016-09-30 Jelle Veraart , Els Fieremans , Dmitry S. Novikov

Recent experiments revealed that the dielectric dispersion spectrum of fission yeast cells in a suspension was mainly composed of two sub-dispersions. The low-frequency sub-dispersion depended on the cell length, while the high-frequency…

软凝聚态物质 · 物理学 2018-01-17 J. P. Huang , K. W. Yu , Jun Lei , Hong Sun

Diffusion MRI (dMRI) is the primary imaging modality used to study brain microstructure in vivo. Reliable and computationally efficient parameter inference for common dMRI biophysical models is a challenging inverse problem, due to factors…

图像与视频处理 · 电气工程与系统科学 2025-03-03 William Consagra , Lipeng Ning , Yogesh Rathi

Differences in magnetic susceptibility between various compartments in heterogeneous samples can introduce unanticipated complications to NMR spectra. On the other hand, an understanding of these effects at the level of the underlying…

细胞行为 · 定量生物学 2009-10-05 P. W. Kuchel , B. E. Chapman , W. A. Bubb , P. E. Hansen , C. J. Durrant , M. P. Hertzberg

Many neuronal systems and models display a certain class of mixed mode oscillations (MMOs) consisting of periods of small amplitude oscillations interspersed with spikes. Various models with different underlying mechanisms have been…

适应与自组织系统 · 物理学 2015-03-13 Peter Borowski , Rachel Kuske , Yue-Xian Li , Juan Luis Cabrera

Mass spectrometry plays a fundamental role in elucidating the structures of unknown molecules and subsequent scientific discoveries. One formulation of the structure elucidation task is the conditional de novo generation of molecular…

机器学习 · 计算机科学 2025-05-29 Montgomery Bohde , Mrunali Manjrekar , Runzhong Wang , Shuiwang Ji , Connor W. Coley

Diffusion probabilistic models (DPMs) have exhibited significant effectiveness in computer vision tasks, particularly in image generation. However, their notable performance heavily relies on labelled datasets, which limits their…

计算机视觉与模式识别 · 计算机科学 2024-05-09 Keqiang Fan , Xiaohao Cai , Mahesan Niranjan

Diffusion MRI may enable non-invasive mapping of axonal microstructure. Most approaches infer axon diameters from effects of time-dependent diffusion on the diffusion-weighted MR signal by modelling axons as straight cylinders. Axons do…

医学物理 · 物理学 2019-03-13 Jan Brabec , Samo Lasic , Markus Nilsson

Diffusion Tensor Cardiac Magnetic Resonance (DT-CMR) is the only in vivo method to non-invasively examine the microstructure of the human heart. Current research in DT-CMR aims to improve the understanding of how the cardiac microstructure…

图像与视频处理 · 电气工程与系统科学 2026-05-19 Yinzhe Wu , Jiahao Huang , Fanwen Wang , Pedro Ferreira , Andrew Scott , Sonia Nielles-Vallespin , Guang Yang

Diffusion-weighted magnetic resonance imaging (DWI) and fiber tractography are the only methods to measure the structure of the white matter in the living human brain. The diffusion signal has been modelled as the combined contribution from…

机器学习 · 统计学 2014-09-29 Charles Zheng , Franco Pestilli , Ariel Rokem