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Mining relationships between treatment(s) and medical problem(s) is vital in the biomedical domain. This helps in various applications, such as decision support system, safety surveillance, and new treatment discovery. We propose a deep…

机器学习 · 计算机科学 2018-07-02 Veera Raghavendra Chikka , Kamalakar Karlapalem

Accurate identification of drug-target interactions (DTI) remains a central challenge in computational pharmacology, where sequence-based methods offer scalability. This work introduces a sequence-based drug-target interaction framework…

Attention mechanisms are often used in deep neural networks for distantly supervised relation extraction (DS-RE) to distinguish valid from noisy instances. However, traditional 1-D vector attention models are insufficient for the learning…

计算与语言 · 计算机科学 2018-09-05 Jinhua Du , Jingguang Han , Andy Way , Dadong Wan

Drug-drug interactions (DDIs) are a major concern in clinical practice, as they can lead to reduced therapeutic efficacy or severe adverse effects. Traditional computational approaches often struggle to capture the complex relationships…

机器学习 · 计算机科学 2025-08-27 Hongbo Liu , Siyi Li , Zheng Yu

Because protein-protein interactions (PPIs) are crucial to understand living systems, harvesting these data is essential to probe disease development and discern gene/protein functions and biological processes. Some curated datasets contain…

生物大分子 · 定量生物学 2024-03-12 Gilchan Park , Sean McCorkle , Carlos Soto , Ian Blaby , Shinjae Yoo

Large language models (LLMs) have significantly improved various aspects of our daily lives. These models have impacted numerous domains, from healthcare to education, enhancing productivity, decision-making processes, and accessibility. As…

机器学习 · 计算机科学 2023-11-01 Zhao Song , Guangyi Xu , Junze Yin

This paper addresses the challenges posed by the unstructured nature and high-dimensional semantic complexity of electronic health record texts. A deep learning method based on attention mechanisms is proposed to achieve unified modeling…

计算与语言 · 计算机科学 2025-07-03 Ting Xu , Xiaoxiao Deng , Xiandong Meng , Haifeng Yang , Yan Wu

Polypharmacy, defined as the use of multiple drugs together, is a standard treatment method, especially for severe and chronic diseases. However, using multiple drugs together may cause interactions between drugs. Drug-drug interaction…

机器学习 · 计算机科学 2022-07-13 Farhan Tanvir , Khaled Mohammed Saifuddin , Esra Akbas

The development of Internet technology has led to a rapid increase in news information. Filtering out valuable content from complex information has become an urgentproblem that needs to be solved. In view of the shortcomings of traditional…

计算与语言 · 计算机科学 2024-09-25 Bingyao Liu , Jiajing Chen , Rui Wang , Junming Huang , Yuanshuai Luo , Jianjun Wei

In this work, we propose a new segmentation network by integrating DenseUNet and bidirectional LSTM together with attention mechanism, termed as DA-BDense-UNet. DenseUNet allows learning enough diverse features and enhancing the…

图像与视频处理 · 电气工程与系统科学 2021-07-27 Wenming Cao , Philip L. H. Yu , Gilbert C. S. Lui , Keith W. H. Chiu , Ho-Ming Cheng , Yanwen Fang , Man-Fung Yuen , Wai-Kay Seto

Concomitant administration of drugs can cause drug-drug interactions (DDIs). Some drug combinations are beneficial, but other ones may cause negative effects which are previously unrecorded. Previous works on DDI prediction usually rely on…

人工智能 · 计算机科学 2022-08-26 Xinyu Zhu , Yongliang Shen , Weiming Lu

Predicting high-dimensional or extreme multilabels, such as in medical coding, requires both accuracy and interpretability. Existing works often rely on local interpretability methods, failing to provide comprehensive explanations of the…

计算与语言 · 计算机科学 2025-03-25 John Wu , David Wu , Jimeng Sun

Drug-Drug Interactions (DDIs) may hamper the functionalities of drugs, and in the worst scenario, they may lead to adverse drug reactions (ADRs). Predicting all DDIs is a challenging and critical problem. Most existing computational models…

定量方法 · 定量生物学 2023-04-19 Khaled Mohammed Saifuddin , Briana Bumgardner , Farhan Tanvir , Esra Akbas

Large language models (LLMs) are commonly trained on multi-domain datasets, where domain sampling strategies significantly impact model performance due to varying domain importance across downstream tasks. Existing approaches for optimizing…

计算与语言 · 计算机科学 2025-08-25 Weijie Shi , Jipeng Zhang , Yaguang Wu , Jingzhi Fang , Ruiyuan Zhang , Jiajie Xu , Jia Zhu , Hao Chen , Yao Zhao , Sirui Han , Xiaofang Zhou

In recent years, deep learning has presented a great advance in hyperspectral image (HSI) classification. Particularly, long short-term memory (LSTM), as a special deep learning structure, has shown great ability in modeling long-term…

计算机视觉与模式识别 · 计算机科学 2022-04-12 Wen-Shuai Hu , Heng-Chao Li , Lei Pan , Wei Li , Ran Tao , Qian Du

The remarkable performance of the pre-trained language model (LM) using self-supervised learning has led to a major paradigm shift in the study of natural language processing. In line with these changes, leveraging the performance of speech…

机器学习 · 计算机科学 2021-10-22 Mun-Hak Lee , Joon-Hyuk Chang

Decoding brain cognitive states from neuroimaging signals is an important topic in neuroscience. In recent years, deep neural networks (DNNs) have been recruited for multiple brain state decoding and achieved good performance. However, the…

图像与视频处理 · 电气工程与系统科学 2021-10-05 Zhoufan Jiang , Yanming Wang , ChenWei Shi , Yueyang Wu , Rongjie Hu , Shishuo Chen , Sheng Hu , Xiaoxiao Wang , Bensheng Qiu

In silico prediction of drug-target interactions (DTI) is significant for drug discovery because it can largely reduce timelines and costs in the drug development process. Specifically, deep learning-based DTI approaches have been shown…

机器学习 · 计算机科学 2021-09-20 Yeachan Kim , Bonggun Shin

Recent progress has been made in using attention based encoder-decoder framework for image and video captioning. Most existing decoders apply the attention mechanism to every generated word including both visual words (e.g., "gun" and…

计算机视觉与模式识别 · 计算机科学 2018-12-31 Jingkuan Song , Xiangpeng Li , Lianli Gao , Heng Tao Shen

Information extraction (IE) plays a crucial role in natural language processing (NLP) by converting unstructured text into structured knowledge. Deploying computationally intensive large language models (LLMs) on resource-constrained…

计算与语言 · 计算机科学 2025-05-22 Zhihao Wen , Sheng Liang , Yaxiong Wu , Yongyue Zhang , Yong Liu