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As the aging population grows, particularly for the baby boomer generation, the United States is witnessing a significant increase in the elderly population experiencing multifunctional disabilities. These disabilities, stemming from a…

机器学习 · 计算机科学 2024-04-09 Suiyao Chen , Xinyi Liu , Yulei Li , Jing Wu , Handong Yao

Machine learning methods have shown large potential for the automatic early diagnosis of Alzheimer's Disease (AD). However, some machine learning methods based on imaging data have poor interpretability because it is usually unclear how…

Longitudinal biomedical studies monitor individuals over time to capture dynamics in brain development, disease progression, and treatment effects. However, estimating trajectories of brain biomarkers is challenging due to biological…

机器学习 · 计算机科学 2025-04-15 Vasiliki Tassopoulou , Haochang Shou , Christos Davatzikos

Schizophrenia is a chronic neuropsychiatric disorder that causes distinct structural alterations within the brain. We hypothesize that deep learning applied to a structural neuroimaging dataset could detect disease-related alteration and…

图像与视频处理 · 电气工程与系统科学 2022-07-08 Junhao Zhang , Vishwanatha M. Rao , Ye Tian , Yanting Yang , Nicolas Acosta , Zihan Wan , Pin-Yu Lee , Chloe Zhang , Lawrence S. Kegeles , Scott A. Small , Jia Guo

Bone age assessment (BAA) is a standard method for determining the age difference between skeletal and chronological age. Manual processes are complicated and necessitate the expertise of experts. This is where deep learning comes into…

图像与视频处理 · 电气工程与系统科学 2022-07-22 Aravinda Raman , Sameena Pathan , Tanweer Ali

Defining vascular age in terms of physiological function has become one focal point of the extensive studies to categorize and track chronological age. Transcranial Doppler (TCD) is a method by which cerebral blood flow velocity is measured…

人工智能 · 计算机科学 2026-05-19 Anni Zhao , Alex Bateh , Tyler Baldridge , Sandra Billinger , Xiao Hu

This paper presents a novel deep learning-based approach for simultaneous age and gender classification from facial images, designed to enhance the effectiveness of targeted advertising campaigns. We propose a custom Convolutional Neural…

计算机视觉与模式识别 · 计算机科学 2025-07-25 Muhammad Imran Zaman , Nisar Ahmed

Given the wide success of convolutional neural networks (CNNs) applied to natural images, researchers have begun to apply them to neuroimaging data. To date, however, exploration of novel CNN architectures tailored to neuroimaging data has…

计算机视觉与模式识别 · 计算机科学 2018-08-15 Pascal Sturmfels , Saige Rutherford , Mike Angstadt , Mark Peterson , Chandra Sripada , Jenna Wiens

Understanding human fetal neurodevelopment is of great clinical importance as abnormal development is linked to adverse neuropsychiatric outcomes after birth. Recent advances in functional Magnetic Resonance Imaging (fMRI) have provided new…

图像与视频处理 · 电气工程与系统科学 2019-06-11 Xiangrui Li , Jasmine Hect , Moriah Thomason , Dongxiao Zhu

While unsupervised variational autoencoders (VAE) have become a powerful tool in neuroimage analysis, their application to supervised learning is under-explored. We aim to close this gap by proposing a unified probabilistic model for…

机器学习 · 计算机科学 2019-07-15 Qingyu Zhao , Ehsan Adeli , Nicolas Honnorat , Tuo Leng , Kilian M. Pohl

Functional connectivity (FC) derived from resting-state fMRI plays a critical role in personalized predictions such as age and cognitive performance. However, applying foundation models(FM) to fMRI data remains challenging due to its high…

神经元与认知 · 定量生物学 2025-08-26 Yanwen Wang , Xinglin Zhao , Yijin Song , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

We present a probabilistic programmed deep kernel learning approach to personalized, predictive modeling of neurodegenerative diseases. Our analysis considers a spectrum of neural and symbolic machine learning approaches, which we assess…

机器学习 · 计算机科学 2021-01-13 Alexander Lavin

Background and Objectives: This paper focuses on using AI to assess the cognitive function of older adults with mild cognitive impairment or mild dementia using physiological data provided by a wearable device. Cognitive screening tools are…

神经元与认知 · 定量生物学 2025-11-10 Assma Habadi , Milos Zefran , Lijuan Yin , Woojin Song , Maria Caceres , Elise Hu , Naoko Muramatsu

Neurodegeneration, characterized by the progressive loss of neuronal structure or function, is commonly assessed in clinical practice through reductions in cortical thickness or brain volume, as visualized by structural MRI. While…

信号处理 · 电气工程与系统科学 2025-10-15 Saurabh Sihag , Gonzalo Mateos , Alejandro Ribeiro

Childhood obesity is a major public health challenge. Early prediction and identification of the children at a high risk of developing childhood obesity may help in engaging earlier and more effective interventions to prevent and manage…

应用统计 · 统计学 2022-05-03 Mehak Gupta , Thao-Ly T. Phan , Timothy Bunnell , Rahmatollah Beheshti

Objective: fMRI and derived measures such as functional connectivity (FC) have been used to predict brain age, general fluid intelligence, psychiatric disease status, and preclinical neurodegenerative disease. However, it is not always…

Brain age prediction models have succeeded in predicting clinical outcomes in neurodegenerative diseases, but can struggle with tasks involving faster progressing diseases and low quality data. To enhance their performance, we employ a…

Bone age assessment is a task performed daily in hospitals worldwide. This involves a clinician estimating the age of a patient from a radiograph of the non-dominant hand. Our approach to automated bone age assessment is to modularise the…

机器学习 · 计算机科学 2014-06-19 Anthony Bagnall , Luke Davis

Preterm newborns undergo various stresses that may materialize as learning problems at school-age. Sleep staging of the Electroencephalogram (EEG), followed by prediction of their brain-age from these sleep states can quantify deviations…

机器学习 · 统计学 2018-09-20 Kirubin Pillay , Maarten De Vos

The aging population of the U.S. drives the prevalence of Alzheimer's disease. Brookmeyer et al. forecasts approximately 15 million Americans will have either clinical AD or mild cognitive impairment by 2060. In response to this urgent…

图像与视频处理 · 电气工程与系统科学 2023-12-01 Long Chen , Liben Chen , Binfeng Xu , Wenxin Zhang , Narges Razavian