相关论文: Design and analysis considerations for a sequentia…
Adaptive designs have been proposed for clinical trials in which the nuisance parameters or alternative of interest are unknown or likely to be misspecified before the trial. Whereas most previous works on adaptive designs and mid-course…
Over two thirds of women of all ages in the UK have experienced some form of sexual harassment in a public space. Recent tragic incidents involving female pedestrians have highlighted some of the personal safety issues that women still face…
Increasing evidence has shown that theory-based health behavior change interventions are more effective than non-theory-based ones. However, only a few segments of relevant studies were theory-based, especially the studies conducted by…
Background: Mental health problems are prevalent in college students. The COVID-19 pandemic exacerbated the problems, and created a surge in the popularity of telehealth and mobile health solutions. Despite that mobile health is a promising…
This paper proposes a Workflow for Assessing Treatment effeCt Heterogeneity (WATCH) in clinical drug development targeted at clinical trial sponsors. WATCH is designed to address the challenges of investigating treatment effect…
This study considers treatment effect models in which others' treatment decisions can affect both one's own treatment and outcome. Focusing on the case of two-player interactions, we formulate treatment decision behavior as a complete…
Randomized experiments play a major role in data-driven decision making across many different fields and disciplines. In medicine, for example, randomized controlled trials (RCTs) are the backbone of clinical trial methodology for testing…
Randomized clinical trials are often designed to assess whether a test treatment prolongs survival relative to a control treatment. Increased patient heterogeneity, while desirable for generalizability of results, can weaken the ability of…
We have developed a mathematical model for in-host virus dynamics that includes spatial chemotaxis and diffusion across a two dimensional surface representing the vaginal or rectal epithelium at primary HIV infection. A linear stability…
Background: This study aims to evaluate the Chicago Teen Pregnancy Prevention Initiative delivery optimization outcomes given policy-neutral and policy-focused approaches to deliver this program to at-risk teens across the City of Chicago.…
Experimental design has emerged as a powerful approach for improving the sample efficiency of A/B testing, yet existing designs rely critically on correctly specified models. We study robust sequential experimental design under model…
Young adults today face unprecedented mental health challenges, yet many hesitate to seek support due to barriers such as accessibility, stigma, and time constraints. Bite-sized well-being interventions offer a promising solution to…
Anti-retroviral drugs can reduce the infectiousness of people living with HIV by about 96%--treatment as prevention or TasP--and can reduce the risk of being infected by an HIV positive person by about 70%--pre-exposure prophylaxis or…
A group sequential clinical trial design can be an attractive option when planning a pivotal trial as this approach has the ability to stop the trial early for success, whilst also being well accepted from a regulatory review perspective.…
The behavior change process is a dynamic journey with different informational and motivational needs across its different stages; yet current technologies for behavior change are static. In our recent deployment of Habito, an activity…
Randomized controlled trials are often run in settings with many subpopulations that may have differential benefits from the treatment being evaluated. We consider the problem of sample selection, i.e., whom to enroll in a randomized trial,…
Micro-randomized trials (MRTs), which sequentially randomize participants at multiple decision times, have gained prominence in digital intervention development. These sequential randomizations are often subject to certain constraints. In…
The randomized controlled trial (RCT) is the gold standard for estimating the average treatment effect (ATE) of a medical intervention but requires 100s-1000s of subjects, making it expensive and difficult to implement. While a cross-over…
Sequential recommendation aims to choose the most suitable items for a user at a specific timestamp given historical behaviors. Existing methods usually model the user behavior sequence based on the transition-based methods like Markov…
The management of chronic heart failure presents significant challenges in modern healthcare, requiring continuous monitoring, early detection of exacerbations, and personalized treatment strategies. This paper presents the preliminary…