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Alzheimer's disease is the most common dementia leading to an irreversible neurodegenerative process. To date, subject revealed advanced brain structural alterations when the diagnosis is established. Therefore, an earlier diagnosis of this…

计算机视觉与模式识别 · 计算机科学 2018-07-10 Kilian Hett , Vinh-Thong Ta , Jose Vicente Manjon , Pierrick Coupé

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we…

图像与视频处理 · 电气工程与系统科学 2025-10-08 Fahad Mostafa , Kannon Hossain , Hafiz Khan

We investigate combining imaging and shape features extracted from MRI for the clinically relevant tasks of brain age prediction and Alzheimer's disease classification. Our proposed model fuses ResNet-extracted image embeddings with shape…

计算机视觉与模式识别 · 计算机科学 2025-01-15 Nairouz Shehata , Carolina Piçarra , Ben Glocker

Graphs are widely used as a natural framework that captures interactions between individual elements represented as nodes in a graph. In medical applications, specifically, nodes can represent individuals within a potentially large…

Imaging and genomic data offer distinct and rich features, and their integration can unveil new insights into the complex landscape of diseases. In this study, we present a novel approach utilizing radiogenomic data including structural MRI…

机器学习 · 计算机科学 2025-05-16 Aditya Raj , Golrokh Mirzaei

In this study we propose a deformation-based framework to jointly model the influence of aging and Alzheimer's disease (AD) on the brain morphological evolution. Our approach combines a spatio-temporal description of both processes into a…

神经元与认知 · 定量生物学 2019-05-27 Raphaël Sivera , Hervé Delingette , Marco Lorenzi , Xavier Pennec , Nicholas Ayache

We propose a method to predict the subject-specific longitudinal progression of brain structures extracted from baseline MRI, and evaluate its performance on Alzheimer's disease data. The disease progression is modeled as a trajectory on a…

计算机视觉与模式识别 · 计算机科学 2017-11-27 Alexandre Bône , Maxime Louis , Alexandre Routier , Jorge Samper , Michael Bacci , Benjamin Charlier , Olivier Colliot , Stanley Durrleman

We study possible relations between the structure of the connectome, white matter connecting different regions of brain, and Alzheimer disease. Regression models in covariates including age, gender and disease status for the extent of white…

统计方法学 · 统计学 2021-04-22 Arkaprava Roy , Subhashis Ghosal , Jeffrey Prescott , Kingshuk Roy Choudhury

Alzheimer's disease is a human brain disease that affects a significant fraction of the population by causing problems with short-term memory, thinking, spatial orientation and behavior, memory loss and other intellectual abilities. Up to…

神经元与认知 · 定量生物学 2012-10-02 Athanasios Alexiou , Panayiotis Vlamos

We introduce a wide and deep neural network for prediction of progression from patients with mild cognitive impairment to Alzheimer's disease. Information from anatomical shape and tabular clinical data (demographics, biomarkers) are fused…

机器学习 · 计算机科学 2020-04-01 Sebastian Pölsterl , Ignacio Sarasua , Benjamín Gutiérrez-Becker , Christian Wachinger

The primary motivation and application in this article come from brain imaging studies on cognitive impairment in elderly subjects with brain disorders. We propose a regularized Haar wavelet-based approach for the analysis of…

应用统计 · 统计学 2014-08-11 Xuejing Wang , Bin Nan , Ji Zhu , Robert Koeppe

We propose a mesh-based technique to aid in the classification of Alzheimer's disease dementia (ADD) using mesh representations of the cortex and subcortical structures. Deep learning methods for classification tasks that utilize structural…

图像与视频处理 · 电气工程与系统科学 2022-03-14 Emanuel A. Azcona , Pierre Besson , Yunan Wu , Arjun Punjabi , Adam Martersteck , Amil Dravid , Todd B. Parrish , S. Kathleen Bandt , Aggelos K. Katsaggelos

Alzheimer's Disease is the most common cause of dementia. Accurate diagnosis and prognosis of this disease are essential to design an appropriate treatment plan, increasing the life expectancy of the patient. Intense research has been…

图像与视频处理 · 电气工程与系统科学 2023-01-05 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

Alzheimer's Disease is a neurodegenerative condition characterized by dementia and impairment in neurological function. The study primarily focuses on the individuals above age 40, affecting their memory, behavior, and cognitive processes…

计算机视觉与模式识别 · 计算机科学 2025-01-20 Mohammad Rafsan , Tamer Oraby , Upal Roy , Sanjeev Kumar , Hansapani Rodrigo

Several biomarkers are hypothesized to indicate early stages of Alzheimer's disease, well before the cognitive symptoms manifest. Their precise relations to the disease progression, however, is poorly understood. This lack of understanding…

应用统计 · 统计学 2025-05-12 Mingyuan Li , Zheyu Wang , Akihiko Nishimura

Early diagnosis and discovery of therapeutic drug targets are crucial objectives for effective management of Alzheimer's Disease (AD). Current approaches for AD diagnosis and treatment planning are based on radiological imaging and largely…

机器学习 · 计算机科学 2026-05-01 Maryam Khalid , Fadeel Sher Khan , John Broussard , Arko Barman

The identification of Alzheimer's disease (AD) and its early stages using structural magnetic resonance imaging (MRI) has been attracting the attention of researchers. Various data-driven approaches have been introduced to capture subtle…

人工智能 · 计算机科学 2021-08-11 Changhyun Park , Heung-Il Suk

Alzheimer's disease affects over 55 million people worldwide and is projected to more than double by 2050, necessitating rapid, accurate, and scalable diagnostics. However, existing approaches are limited because they cannot achieve…

计算机视觉与模式识别 · 计算机科学 2025-07-29 Ahmed Sharshar , Yasser Ashraf , Tameem Bakr , Salma Hassan , Hosam Elgendy , Mohammad Yaqub , Mohsen Guizani

Imaging-based early diagnosis of Alzheimer Disease (AD) has become an effective approach, especially by using nuclear medicine imaging techniques such as Positron Emission Topography (PET). In various literature it has been found that PET…

机器学习 · 计算机科学 2021-03-24 Jiaming Guo , Wei Qiu , Xiang Li , Xuandong Zhao , Ning Guo , Quanzheng Li

Early and accessible detection of Alzheimer's disease (AD) remains a critical clinical challenge, and cube-copying tasks offer a simple yet informative assessment of visuospatial function. This work proposes a multimodal framework that…

机器学习 · 计算机科学 2025-12-19 Jaeho Yang , Kijung Yoon
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