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Given a dataset of individuals each described by a covariate vector, a treatment, and an observed outcome on the treatment, the goal of the individual treatment effect (ITE) estimation task is to predict outcome changes resulting from a…

机器学习 · 计算机科学 2024-06-07 Lokesh Nagalapatti , Pranava Singhal , Avishek Ghosh , Sunita Sarawagi

Balancing influential covariates is crucial for valid treatment comparisons in clinical studies. While covariate-adaptive randomization is commonly used to achieve balance, its performance can be inadequate when the number of baseline…

统计方法学 · 统计学 2024-12-30 Ziqing Guo , Yang Liu , Lucy Xia

When estimating causal effects from observational data with numerous covariates, employing penalized covariate selection can improve the estimation efficiency. Outcome-oriented covariate selection, which involves selecting covariates…

统计方法学 · 统计学 2025-01-14 Wataru Hongo , Shuji Ando , Jun Tsuchida , Takashi Sozu

The survey experiment is widely used in economics and social sciences to evaluate the effects of treatments or programs. In a standard population-based survey experiment, the experimenter randomly draws experimental units from a target…

统计方法学 · 统计学 2026-05-11 Pengfei Tian , Jiyang Ren , Yingying Ma

Firms increasingly use randomized experiments to decide whether to scale up an intervention and, if so, how to re-optimize related operational choices such as inventory, capacity, or pricing. In many settings, experiments are performed on…

统计方法学 · 统计学 2026-03-12 Guoxing He , Dan Yang , Wei Zhang

We consider the optimal experimental design problem of allocating subjects to treatment or control when subjects participate in multiple, separate controlled experiments within a short time-frame and subject covariate information is…

统计方法学 · 统计学 2024-12-16 William Fisher , Qiong Zhang , Lulu Kang , Xinwei Deng

Classical randomized experiments, equipped with randomization-based inference, provide assumption-free inference for treatment effects. They have been the gold standard for drawing causal inference and provide excellent internal validity.…

统计方法学 · 统计学 2021-09-22 Zihao Yang , Tianyi Qu , Xinran Li

Bipartite Experiments are randomized experiments where the treatment is applied to a set of units (randomization units) that is different from the units of analysis, and randomization units and analysis units are connected through a…

统计方法学 · 统计学 2025-11-05 Liang Shi , Edvard Bakhitov , Kenneth Hung , Brian Karrer , Charlie Walker , Monica Bhole , Okke Schrijvers

Background: Subgroup analyses are frequently conducted in randomized clinical trials to assess evidence of heterogeneous treatment effect across patient subpopulations. Although randomization balances covariates within subgroups in…

统计方法学 · 统计学 2021-05-27 Siyun Yang , Fan Li , Laine E. Thomas , Fan Li

This paper studies inference for the local average treatment effect in randomized controlled trials with imperfect compliance where treatment status is determined according to "matched pairs." By "matched pairs," we mean that units are…

计量经济学 · 经济学 2024-06-28 Yuehao Bai , Hongchang Guo , Azeem M. Shaikh , Max Tabord-Meehan

A basic feature of many field experiments is that investigators are only able to randomize clusters of individuals--such as households, communities, firms, medical practices, schools or classrooms--even when the individual is the unit of…

统计方法学 · 统计学 2009-10-21 Kosuke Imai , Gary King , Clayton Nall

For randomized controlled trials (RCTs) with a single intervention being measured on multiple outcomes, researchers often apply a multiple testing procedure (such as Bonferroni or Benjamini-Hochberg) to adjust $p$-values. Such an adjustment…

统计方法学 · 统计学 2023-05-17 Kristen Hunter , Luke Miratrix , Kristin Porter

In this paper, I try to tame "Basu's elephants" (data with extreme selection on observables). I propose new practical large-sample and finite-sample methods for estimating and inferring heterogeneous causal effects (under unconfoundedness)…

计量经济学 · 经济学 2023-01-20 Ganesh Karapakula

Randomized controlled trials generate experimental variation that can credibly identify causal effects, but often suffer from limited scale, while observational datasets are large, but often violate desired identification assumptions. To…

计量经济学 · 经济学 2023-12-27 George Z. Gui

With medical tests becoming increasingly available, concerns about over-testing and over-treatment dramatically increase. Hence, it is important to understand the influence of testing on treatment selection in general practice. Most…

统计方法学 · 统计学 2020-08-11 Yun Li , Irina Bondarenko , Michael R. Elliott , Timothy P. Hofer , Jeremy M. G. Taylor

In recent years, there is a growing body of causal inference literature focusing on covariate balancing methods. These methods eliminate observed confounding by equalizing covariate moments between the treated and control groups. The…

统计方法学 · 统计学 2024-06-14 Xialing Wen , Ying Yan

We provide guidance on multiple imputation of missing at random treatments in observational studies. Specifically, analysts should account for both covariates and outcomes, i.e., not just use propensity scores, when imputing the missing…

统计方法学 · 统计学 2025-01-23 Joseph Feldman , Jerome P. Reiter

Covariate adaptive randomization (CAR) procedures are extensively used to reduce the likelihood of covariate imbalances occurring in clinical trials. In literatures, a lot of CAR procedures have been proposed so that the specified…

统计理论 · 数学 2026-03-10 Zhang Li-Xin

In this paper, we propose a data-adaptive empirical likelihood-based approach for treatment effect estimation and inference, which overcomes the obstacle of the traditional empirical likelihood-based approaches in the high-dimensional…

统计方法学 · 统计学 2020-12-15 Wei Liang , Ying Yan

The growing availability of large health databases has expanded the use of observational studies for comparative effectiveness research. Unlike randomized trials, observational studies must adjust for systematic differences in patient…

统计方法学 · 统计学 2026-01-21 Haidong Lu , Fan Li , Laine E. Thomas , Fan Li