相关论文: Modeling Interference-Free Neuron Spikes with Opto…
We investigate the stimulus-dependent tuning properties of a noisy ionic conductance model for intrinsic subthreshold oscillations in membrane potential and associated spike generation. On depolarization by an applied current, the model…
We study a network model of two conductance-based pacemaker neurons of differing natural frequency, coupled with either mutual excitation or inhibition, and receiving shared random inhibitory synaptic input. The networks may phase-lock…
The brain is composed of complex networks of interacting neurons that express considerable heterogeneity in their physiology and spiking characteristics. How does neural heterogeneity affect macroscopic neural dynamics and how does it…
We continue the work of a series of previous studies of a mathematical model that describes the mean-field limit behavior of a homogeneous network of excitatory point spiking neurons. Contrary to other models, here noise is intrinsic to the…
Objective. Long-term potentiation (LTP) is a fundamental mechanism underlying learning and memory, yet its investigation at the network level in vitro remains challenging, particularly when optogenetic stimulation is used. The objective of…
We study a learning rule based upon the temporal correlation (weighted by a learning kernel) between incoming spikes and the internal state of the postsynaptic neuron, building upon previous studies of spike timing dependent synaptic…
Neurons fire irregularly on multiple timescales when stimulated with a periodic pulse train. This raises two questions: Does this irregularity imply significant intrinsic stochasticity? Can existing neuron models be readily extended to…
In this work, a spiking neural network (SNN) is proposed for approximating differential sensorimotor maps of robotic systems. The computed model is used as a local Jacobian-like projection that relates changes in sensor space to changes in…
Optogenetics is an emerging field of neuroscience where neurons are genetically modified to express light-sensitive receptors that enable external control over when the neurons fire. Given the prominence of neuronal signaling within the…
Using a stochastic generalization of the Hodgkin–Huxley model, we consider the influence of intrinsic channel noise on the synchronization between the spiking activity of the excitable membrane and an externally applied periodic…
The modular and hierarchical organization of the brain is believed to support the coexistence of segregated (specialization) and integrated (binding) information processes. A relevant question is yet to understand how such architecture…
In this work, we propose to catch the complexity of the membrane potential's dynamic of a motoneuron between its spikes, taking into account the spikes from other neurons around. Our approach relies on two types of data: extracellular…
In this paper, we propose a shot noise-based leaky integrated and firing neuron model and provide a detailed analysis of the performance of this model compared to the traditional diffusion approximated model. In theoretical neuroscience,…
Excitation-inhibition (E-I) balance is ubiquitously observed in the cortex. Recent studies suggest an intriguing link between balance on fast timescales, tight balance, and efficient information coding with spikes. We further this…
We examine the effects of stochastic input currents on the firing behavior of two excitable neurons coupled with fast excitatory synapses. In such cells (models), typified by the quadratic integrate and fire model, mutual synaptic coupling…
We study a problem of designing ``robust'' external excitations for control and synchronization of an assembly of homotypic harmonic oscillators representing so-called theta neurons. The model of theta neurons (Theta model) captures, in…
Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn, can modulate behavior in live organisms. However, detecting the response to the optical stimulation requires electrophysiology with physical…
In a generic neuron model, we present the linear response theory for the firing rate in response to both time dependent input currents and noise amplitudes. In both cases the signal transmission is strongly attenuated for frequencies above…
Human brain is functionally and physically complex. This 'complexity' can be seen as a result of biological design process involving extensive use of concepts such as modularity and hierarchy. Over the past decade, deeper insights into the…
The behaviour of neurons under the influence of periodic external input has been modelled very successfully by circle maps. The aim of this note is to extend certain aspects of this analysis to a much more general class of forcing…