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Distinguishing signal of young gas rich circumstellar disks from stellar signal in near infrared light is a difficult task. Current techniques such as Angular Differential Imaging (ADI) and Polarimetric Differential Imaging (PDI) cope with…

天体物理仪器与方法 · 物理学 2022-12-07 L. M. Stapper , C. Ginski

Holotomography (HT) has revolutionized quantitative label-free 3D imaging, yet conventional lens-based implementations are fundamentally constrained in field-of-view (FOV) and imaging depth, limiting their utility for critical…

Optical Diffraction Tomography (ODT) is a powerful non-invasive imaging technique widely used in biological and medical applications. While significant progress has been made in transmission configuration, reflection ODT remains challenging…

光学 · 物理学 2026-05-14 Thomas Wasik , Victor Barolle , Alexandre Aubry , Josselin Garnier

Three-dimensional imaging of biological cells is crucial for the investigation of cell biology, provide valuable information to reveal the mechanisms behind pathophysiology of cells and tissues. Recent advances in optical diffraction…

生物物理 · 物理学 2016-03-03 Kyoohyun Kim , Jonghee Yoon , Seungwoo Shin , SangYun Lee , Su-A Yang , YongKeun Park

Despite the remarkable success, recent reconstruction-based anomaly detection (AD) methods via diffusion modeling still involve fine-grained noise-strength tuning and computationally expensive multi-step denoising, leading to a fundamental…

计算机视觉与模式识别 · 计算机科学 2026-03-13 Shunsuke Sakai , Xiangteng He , Chunzhi Gu , Leonid Sigal , Tatsuhito Hasegawa

Deep learning methods for accelerated MRI achieve state-of-the-art results but largely ignore additional speedups possible with noncartesian sampling trajectories. To address this gap, we created a generative diffusion model-based…

人工智能 · 计算机科学 2024-10-02 Trevor J. Chan , Chamith S. Rajapakse

Here, we present a novel microscopic technique for measuring wavelength-dependent three-dimensional (3-D) distributions of the refractive indices (RIs) of microscopic samples in the visible wavelengths. Employing 3-D quantitative phase…

光学 · 物理学 2016-04-20 JaeHwang Jung , Kyoohyun Kim , Jonghee Yoon , YongKeun Park

Lens-free Shadow Imaging Technique (LSIT) is a well-established technique for the characterization of microparticles and biological cells. Due to its simplicity and cost-effectiveness, various low-cost solutions have been evolved, such as…

图像与视频处理 · 电气工程与系统科学 2022-03-04 Rajkumar Vaghashiya , Sanghoon Shin , Varun Chauhan , Kaushal Kapadiya , Smit Sanghavi , Sungkyu Seo , Mohendra Roy

Label-free tomographic microscopy offers a compelling means to visualize three-dimensional (3D) refractive index (RI) distributions from two-dimensional (2D) intensity measurements. However, limited forward-model accuracy and the ill-posed…

光学 · 物理学 2025-02-27 Delong Yang , Shaohui Zhang , Jiasong Sun , Chao Zuo , Qun Hao

We present a novel illumination control technique for optical diffraction tomography (ODT). Various spatial frequencies of beam illumination were controlled by displaying time-averaged sinusoidal patterns using a digital micromirror device…

生物物理 · 物理学 2017-04-05 Kyeoreh Lee , Kyoohyun Kim , Geon Kim , Seungwoo Shin , YongKeun Park

Dynamic full-field optical coherence tomography (D-FFOCT) has recently emerged as a label-free imaging tool, capable of resolving cell types and organelles within 3D live samples, whilst monitoring their activity at tens of milliseconds…

Diffusion Transformers (DiTs) have emerged as a leading architecture for text-to-image synthesis, producing high-quality and photorealistic images. However, the quadratic scaling properties of the attention in DiTs hinder image generation…

计算机视觉与模式识别 · 计算机科学 2025-08-12 Philipp Becker , Abhinav Mehrotra , Ruchika Chavhan , Malcolm Chadwick , Luca Morreale , Mehdi Noroozi , Alberto Gil Ramos , Sourav Bhattacharya

Reflection phase imaging provides label-free, high-resolution characterization of biological samples, typically using interferometric-based techniques. Here, we investigate reflection phase microscopy from intensity-only measurements under…

定量方法 · 定量生物学 2019-12-18 Alex Matlock , Anne Sentenac , Patrick C. Chaumet , Ji Yi , Lei Tian

We introduce a novel reflection-mode diffraction tomography technique that enables simultaneous recovery of forward and backward scattering information for high-resolution 3D refractive index reconstruction. Our technique works by imaging a…

光学 · 物理学 2025-02-12 Tongyu Li , Jiabei Zhu , Yi Shen , Lei Tian

Label-free microscopy exploits light scattering to obtain a three-dimensional image of biological tissues. However, light propagation is affected by aberrations and multiple scattering, which drastically degrade the image quality and limit…

Optical diffraction tomography (ODT) is a tomographic technique that can be used to measure the three-dimensional (3D) refractive index distribution within living cells without the requirement of any marker. In principle, ODT can be…

定量方法 · 定量生物学 2018-01-03 Paul Müller , Mirjam Schürmann , Chii J. Chan , Jochen Guck

This work introduces a novel reinterpretation of structured illumination (SI) microscopy for coherent imaging that allows three-dimensional imaging of complex refractive index (RI). To do so, we show that coherent SI is mathematically…

光学 · 物理学 2017-05-11 Shwetadwip Chowdhury , Will J. Eldridge , Adam Wax , Joseph A. Izatt

Optical diffraction tomography (ODT) is a three-dimensional (3D) label-free imaging technique. The 3D refractive index distribution of a sample can be reconstructed from multiple two-dimensional optical field images via ODT. Herein, we…

光学 · 物理学 2021-02-03 Chansuk Park , Kyeoreh Lee , Yoonseok Baek , Yongkeun Park

Determining physical properties inside an object without access to direct measurements of target regions can be formulated as a specific type of \textit{inverse problem}. One of such problems is applied in \textit{Electrical Impedance…

数值分析 · 数学 2023-01-30 Ivan Pombo , Luis Sarmento

Volumetric optical microscopy using non-diffracting beams enables rapid imaging of 3D volumes by projecting them axially to 2D images but lacks crucial depth information. Addressing this, we introduce MicroDiffusion, a pioneering tool…

图像与视频处理 · 电气工程与系统科学 2024-03-19 Mude Hui , Zihao Wei , Hongru Zhu , Fei Xia , Yuyin Zhou