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We propose a method to accurately obtain the ratio of tumor cells over an entire histological slide. We use deep fully convolutional neural network models trained to detect and classify cells on images of H&E-stained tissue sections.…

图像与视频处理 · 电气工程与系统科学 2021-01-29 Eric Cosatto , Kyle Gerard , Hans-Peter Graf , Maki Ogura , Tomoharu Kiyuna , Kanako C. Hatanaka , Yoshihiro Matsuno , Yutaka Hatanaka

Image clustering is an important and open-challenging task in computer vision. Although many methods have been proposed to solve the image clustering task, they only explore images and uncover clusters according to the image features, thus…

计算机视觉与模式识别 · 计算机科学 2023-04-11 Shaotian Cai , Liping Qiu , Xiaojun Chen , Qin Zhang , Longteng Chen

Self-supervised pretraining attempts to enhance model performance by obtaining effective features from unlabeled data, and has demonstrated its effectiveness in the field of histopathology images. Despite its success, few works concentrate…

计算机视觉与模式识别 · 计算机科学 2023-09-22 Zhiyun Song , Penghui Du , Junpeng Yan , Kailu Li , Jianzhong Shou , Maode Lai , Yubo Fan , Yan Xu

Brain tumor segmentation is important for diagnosis of the tumor, and current deep-learning methods rely on a large set of annotated images for training, with high annotation costs. Unsupervised segmentation is promising to avoid human…

计算机视觉与模式识别 · 计算机科学 2025-01-28 Xiaochuan Ma , Jia Fu , Wenjun Liao , Shichuan Zhang , Guotai Wang

Lung squamous cell carcinoma (LSCC) has a high recurrence and metastasis rate. Factors influencing recurrence and metastasis are currently unknown and there are no distinct histopathological or morphological features indicating the risks of…

计算机视觉与模式识别 · 计算机科学 2023-02-09 Weicheng Zhu , Carlos Fernandez-Granda , Narges Razavian

Developing an AI-assisted gland segmentation method from histology images is critical for automatic cancer diagnosis and prognosis; however, the high cost of pixel-level annotations hinders its applications to broader diseases. Existing…

计算机视觉与模式识别 · 计算机科学 2022-06-28 Yi Li , Yiduo Yu , Yiwen Zou , Tianqi Xiang , Xiaomeng Li

Breast cancer is one of the main causes of cancer death worldwide. Early diagnostics significantly increases the chances of correct treatment and survival, but this process is tedious and often leads to a disagreement between pathologists.…

计算机视觉与模式识别 · 计算机科学 2018-06-26 Alexander Rakhlin , Alexey Shvets , Vladimir Iglovikov , Alexandr A. Kalinin

The evolutionary classification of molecular clumps, crucial for understanding star formation, is commonly based on human-assigned categories derived from infrared (IR) emission and well-established morphological criteria. However, due to…

Accurate recurrence risk stratification is crucial for optimizing treatment plans for breast cancer patients. Current prognostic tools like Oncotype DX (ODX) offer valuable genomic insights for HR+/HER2- patients but are limited by cost and…

图像与视频处理 · 电气工程与系统科学 2024-09-25 Ziyu Su , Yongxin Guo , Robert Wesolowski , Gary Tozbikian , Nathaniel S. O'Connell , M. Khalid Khan Niazi , Metin N. Gurcan

Convolutional Neural Networks have shown promising effectiveness in identifying different types of cancer from radiographs. However, the opaque nature of CNNs makes it difficult to fully understand the way they operate, limiting their…

图像与视频处理 · 电气工程与系统科学 2026-03-16 Michael Okonoda , Eder Martinez , Abhilekha Dalal , Lior Shamir

The effective management of brain tumors relies on precise typing, subtyping, and grading. This study advances patient care with findings from rigorous multiple instance learning experimentations across various feature extractors and…

计算机视觉与模式识别 · 计算机科学 2024-03-11 Ekansh Chauhan , Amit Sharma , Megha S Uppin , C. V. Jawahar , P. K. Vinod

Automatic non-invasive assessment of hepatocellular carcinoma (HCC) malignancy has the potential to substantially enhance tumor treatment strategies for HCC patients. In this work we present a novel framework to automatically characterize…

According to the National Cancer Institute, there were 9.5 million cancer-related deaths in 2018. A challenge in improving treatment is resistance in genetically unstable cells. The purpose of this study is to evaluate unsupervised machine…

基因组学 · 定量生物学 2021-08-12 Anastasia Dunca , Frederick R. Adler

Recently, deep neural networks have greatly advanced histopathology image segmentation but usually require abundant annotated data. However, due to the gigapixel scale of whole slide images and pathologists' heavy daily workload, obtaining…

计算机视觉与模式识别 · 计算机科学 2023-03-13 Wentao Pan , Jiangpeng Yan , Hanbo Chen , Jiawei Yang , Zhe Xu , Xiu Li , Jianhua Yao

Cancers are characterized by remarkable heterogeneity and diverse prognosis. Accurate cancer classification is essential for patient stratification and clinical decision-making. Although digital pathology has been advancing cancer diagnosis…

计算机视觉与模式识别 · 计算机科学 2025-02-13 Xiaofei Wang , Hanyu Liu , Yupei Zhang , Boyang Zhao , Hao Duan , Wanming Hu , Yonggao Mou , Stephen Price , Chao Li

This work presents a novel self-supervised pre-training method to learn efficient representations without labels on histopathology medical images utilizing magnification factors. Other state-of-theart works mainly focus on fully supervised…

图像与视频处理 · 电气工程与系统科学 2022-09-09 Prakash Chandra Chhipa , Richa Upadhyay , Gustav Grund Pihlgren , Rajkumar Saini , Seiichi Uchida , Marcus Liwicki

Breast cancer treatment still remains a challenge, where molecular subtypes classification plays a crucial role in selecting appropriate and specific therapy. The four subtypes are Luminal A (LA), Luminal B (LB), HER2 subtype, and…

机器学习 · 计算机科学 2023-10-24 Matheus del-Valle , Emerson Soares Bernardes , Denise Maria Zezell

Unsupervised learning has been a long-standing goal of machine learning and is especially important for medical image analysis, where the learning can compensate for the scarcity of labeled datasets. A promising subclass of unsupervised…

图像与视频处理 · 电气工程与系统科学 2021-09-09 Ozan Ciga , Tony Xu , Anne L. Martel

The advent of digital pathology presents opportunities for computer vision for fast, accurate, and objective solutions for histopathological images and aid in knowledge discovery. This work uses deep learning to predict genomic biomarkers -…

计算机视觉与模式识别 · 计算机科学 2021-03-16 Ruchi Chauhan , PK Vinod , CV Jawahar

Due to the complexity of cancer, clustering algorithms have been used to disentangle the observed heterogeneity and identify cancer subtypes that can be treated specifically. While kernel based clustering approaches allow the use of more…

机器学习 · 统计学 2018-11-21 Nora K. Speicher , Nico Pfeifer