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Fluorescence microscopy is a powerful tool for imaging biological samples with molecular specificity. In contrast, phase microscopy provides label-free measurement of the sample's refractive index (RI), which is an intrinsic optical…

光学 · 物理学 2022-01-26 Yi Xue , David Ren , Laura Waller

Brillouin Light Scattering is a powerful technique to measure the microwave excitations present in a magnetic system. In microfocused mode, the light is focused on the sample using a microscope objective. This accelerates substantially the…

介观与纳米尺度物理 · 物理学 2025-06-30 Nessrine Benaziz , Thibaut Devolder , Jean-Paul Adam

In this work, we report the application of Raman microspectroscopy for analysis of the refractive index of a range of tissue phantoms. Using both a custom-developed setup with visible laser source and a commercial micro-spectrometer with…

Brillouin microscopy is an emerging optical elastography technique that can be used to assess mechanical properties of biological samples in a 3D, all-optical and hence non-contact fashion. However, the low cross-section of spontaneous…

光学 · 物理学 2024-09-04 Carlo Bevilacqua , Robert Prevedel

A direct-detection Brillouin optical time-domain reflectometry (BOTDR) is proposed and demonstrated by using an up-conversion single-photon detector and a fiber Fabry-Perot scanning interferometer (FFP-SI). Taking advantage of high…

Non-contact measurement of the refractive index and thickness of multilayer biological tissues is of great significance for biomedical applications and can greatly improve medical diagnosis and treatment. In this work, we introduce a…

光学 · 物理学 2024-04-19 Yu-Lin Ku , Yao-Gen Shu

Frequency- and time-domain Brillouin scattering spectroscopy are powerful tools to read out the mechanical properties of complex systems in material and life sciences. Indeed, coherent acoustic phonons in the time-domain method offer…

光学 · 物理学 2023-01-06 Ayumu Ishijima , Shinga Okabe , Ichiro Sakuma , Keiichi Nakagawa

Refractive index is a fundamental optical property of powder and a key input to the measurement of the size distribution using light scattering and the measurement of the absorption and scattering coefficients using diffuse reflectance…

光学 · 物理学 2024-03-05 Cory Juntunen , Adam J. Rish , Carl Anderson , Yongjin Sung

In this work, we propose a novel method for continuous real-time measurement of the dynamics of the nonlinear refractive index n2. This is particularly important for characterizing phenomena or materials (such as biological tissues, gases…

White light spectral interferometry is applied to measure the refractive index in absorbing liquids in the spectral range from 400 to 1000 nm. We analyze the influence of absorption on the visibility of interferometric fringes and,…

The interaction of optical and acoustic waves via stimulated Brillouin scattering (SBS) has recently reached on-chip platforms, which has opened new fields of applications ranging from integrated microwave photonics and on-chip…

Stimulated Brillouin scattering (SBS) microscopy enables label-free biomechanical imaging, with Brillouin gain serving as a critical contrast parameter for quantitative analysis. However, the influence of sample-induced refractive index…

光学 · 物理学 2026-04-03 Meng Xu , Zixuan Du , Yun Qi , Jinrui Zhang , Shuai Yao , Robert Prevedel , Fan Yang

Optical spectrometers are indispensable tools across various fields, from chemical and biological sensing to astronomical observations and quantum technologies. However, the integration of spectrometers onto photonic chips has been hindered…

We describe an easy-to-implement technique that allows for a complete experimental characterization of sub-wavelength diameter tapered optical fibers. Our method is based on a direct and fast numerical analysis of the backward Brillouin…

For the first time, a direct detection BOTDR is demonstrated for distributed dynamic strain sensing incorporating double-edge technique, time-division multiplexing technique and upconversion technique. The double edges are realized by using…

仪器与探测器 · 物理学 2017-10-04 Mingjia Shangguan , Chong Wang , Haiyun Xia , Jiawei Qiu , Guoliang Shentu , Xiankang Dou , Qiang Zhang , Jian-wei Pan

Mass density is a vital property for improved biophysical understanding of and within biological samples. It is increasingly attracting active investigation, but still lacks reliable, non-contact techniques to accurately characterize it in…

软凝聚态物质 · 物理学 2025-08-12 Conrad Möckel , Jiarui Li , Giulia Zanini , Jochen Guck , Giuliano Scarcelli

We show that the refractive index modification photoinduced in a biased nonlinear photorefractive crystal can be accurately measured and controlled by means of a background incoherent illumination and an external electric field. The…

Brillouin microscopy is an emerging technique for all-optical biomechanical imaging without the need for physical contact with the sample or for an external mechanical stimulus. However, Brillouin microscopy often retrieves a single,…

光学 · 物理学 2024-02-27 Roni Shaashoua , Tal Levy , Barak Rotblat , Alberto Bilenca

With the development of terahertz time-domain spectroscopy, methods have been proposed to precisely estimate the thickness, refractive index, and attenuation coefficient of a sample. In this article, we propose a new method to compute these…

Direct detection of phonons is important for the investigation of information interconversion between the resonantly coupled magnons and phonons. Here we report resonant coupling of magnons and phonons, which can be directly visualized by…

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