相关论文: Conditioning by adaptive sampling for robust desig…

We consider the optimization of an uncertain objective over continuous and multi-dimensional decision spaces in problems in which we are only provided with observational data. We propose a novel algorithmic framework that is tractable,…

Designing DNA and protein sequences with improved function has the potential to greatly accelerate synthetic biology. Machine learning models that accurately predict biological fitness from sequence are becoming a powerful tool for…

We propose a novel technique for algorithm-selection, applicable to optimisation domains in which there is implicit sequential information encapsulated in the data, e.g., in online bin-packing. Specifically we train two types of recurrent…

Because the expense of estimating the optimal value of the relaxation parameter in the successive over-relaxation (SOR) method is usually prohibitive, the parameter is often adaptively controlled. In this paper, new adaptive SOR methods are…

We consider a measurement constrained supervised learning problem, that is, (1) full sample of the predictors are given; (2) the response observations are unavailable and expensive to measure. Thus, it is ideal to select a subsample of…

Recently, it has been shown how sampling actions from the predictive distribution over the optimal action-sometimes called Thompson sampling-can be applied to solve sequential adaptive control problems, when the optimal policy is known for…

Structural variants compose the majority of human genetic variation, but are difficult to assess using current genomic sequencing technologies. Optical mapping technologies, which measure the size of chromosomal fragments between labeled…

As deep vision models' popularity rapidly increases, there is a growing emphasis on explanations for model predictions. The inherently explainable attribution method aims to enhance the understanding of model behavior by identifying the…

This work is devoted to solving the composite optimization problem with the mixture oracle: for the smooth part of the problem, we have access to the gradient, and for the non-smooth part, only the one-point zero-order oracle is available.…

Sampling is a common strategy for generating text from probabilistic models, yet standard ancestral sampling often results in text that is incoherent or ungrammatical. To alleviate this issue, various modifications to a model's sampling…

A long-standing goal of machine-learning-based protein engineering is to accelerate the discovery of novel mutations that improve the function of a known protein. We introduce a sampling framework for evolving proteins in silico that…

This survey is focused on certain sequential decision-making problems that involve optimizing over probability functions. We discuss the relevance of these problems for learning and control. The survey is organized around a framework that…

Many machine learning tasks, such as learning with invariance and policy evaluation in reinforcement learning, can be characterized as problems of learning from conditional distributions. In such problems, each sample $x$ itself is…

In this paper we propose a method for applications oriented input design for linear systems under time-domain constraints on the amplitude of input and output signals. The method guarantees a desired control performance for the estimated…

Population-based evolutionary algorithms have great potential to handle multiobjective optimisation problems. However, these algorithms depends largely on problem characteristics, and there is a need to improve their performance for a wider…

The problem of sequentially maximizing the expectation of a function seeks to maximize the expected value of a function of interest without having direct control on its features. Instead, the distribution of such features depends on a given…

We propose and discuss a novel strategy for protein design. The method is based on recent theoretical advancements which showed the importance to treat carefully the conformational free energy of designed sequences. In this work we show how…

Interpretable machine learning offers insights into what factors drive a certain prediction of a black-box system. A large number of interpreting methods focus on identifying explanatory input features, which generally fall into two main…

Every organism in an environment, whether biological, robotic or virtual, must be able to predict certain aspects of its environment in order to survive or perform whatever task is intended. It needs a model that is capable of estimating…

Test-time compute scaling allocates inference computation uniformly, uses fixed sampling strategies, and applies verification only for reranking. In contrast, we propose a verifier-guided adaptive framework treating reasoning as iterative…