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Network control theory has recently emerged as a promising approach for understanding brain function and dynamics. By operationalizing notions of control theory for brain networks, it offers a fundamental explanation for how brain dynamics…

定量方法 · 定量生物学 2020-03-20 Shikuang Deng , Shi Gu

Cognitive function is driven by dynamic interactions between large-scale neural circuits or networks, enabling behavior. Fundamental principles constraining these dynamic network processes have remained elusive. Here we use network control…

神经元与认知 · 定量生物学 2015-10-28 Shi Gu , Fabio Pasqualetti , Matthew Cieslak , Scott T. Grafton , Danielle S. Bassett

Cognition is supported by neurophysiological processes that occur both in local anatomical neighborhoods and in distributed large-scale circuits. Recent evidence from network control theory suggests that white matter pathways linking…

神经元与认知 · 定量生物学 2016-06-30 John D. Medaglia , Shi Gu , Fabio Pasqualetti , Rebecca L. Ashare , Caryn Lerman , Joseph Kable , Danielle S. Bassett

The ability to effectively control brain dynamics holds great promise for the enhancement of cognitive function in humans, and the betterment of their quality of life. Yet, successfully controlling dynamics in neural systems is challenging,…

定量方法 · 定量生物学 2018-08-29 Evelyn Tang , Danielle S. Bassett

Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool…

神经元与认知 · 定量生物学 2019-08-12 Teresa M. Karrer , Jason Z. Kim , Jennifer Stiso , Ari E. Kahn , Fabio Pasqualetti , Ute Habel , Danielle S. Bassett

The human brain is a complex network of interconnected brain regions organized into functional modules with distinct roles in cognition and behavior. An important question concerns the persistence and stability of these modules over the…

神经元与认知 · 定量生物学 2015-10-28 Richard F. Betzel , Bratislav Mišić , Ye He , Jeffrey Rumschlag , Xi-Nian Zuo , Olaf Sporns

Activity in the human brain moves between diverse functional states to meet the demands of our dynamic environment, but fundamental principles guiding these transitions remain poorly understood. Here, we capitalize on recent advances in…

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

神经元与认知 · 定量生物学 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

Recent studies have been using graph theoretical approaches to model complex networks (such as social, infrastructural or biological networks), and how their hardwired circuitry relates to their dynamic evolution in time. Understanding how…

神经元与认知 · 定量生物学 2015-07-17 Anca Radulescu

To meet ongoing cognitive demands, the human brain must seamlessly transition from one brain state to another, in the process drawing on different cognitive systems. How does the brain's network of anatomical connections help facilitate…

神经元与认知 · 定量生物学 2016-09-08 Richard F. Betzel , Shi Gu , John D. Medaglia , Fabio Pasqualetti , Danielle S. Bassett

Network controllability is a powerful tool to study causal relationships in complex systems and identify the driver nodes for steering the network dynamics into desired states. However, due to ill-posed conditions, results become unreliable…

The brain is an intricately structured organ responsible for the rich emergent dynamics that support the complex cognitive functions we enjoy as humans. With around $10^{11}$ neurons and $10^{15}$ synapses, understanding how the human brain…

神经元与认知 · 定量生物学 2019-02-12 Jason Z. Kim , Danielle S. Bassett

Cognitive control is a suite of processes that helps individuals pursue goals despite resistance or uncertainty about what to do. Although cognitive control has been extensively studied as a dynamic feedback loop of perception, valuation,…

At the macroscale, the brain operates as a network of interconnected neuronal populations, which display rhythmic dynamics that support interareal communication. Understanding how stimulation of a particular brain area impacts such…

神经元与认知 · 定量生物学 2020-11-12 Lia Papadopoulos , Christopher W. Lynn , Demian Battaglia , Danielle S. Bassett

Correlated fluctuations in the activity of neural populations reflect the network's dynamics and connectivity. The temporal and spatial dimensions of neural correlations are interdependent. However, prior theoretical work mainly analyzed…

神经元与认知 · 定量生物学 2022-07-19 Yan-Liang Shi , Roxana Zeraati , Anna Levina , Tatiana A. Engel

The human brain exhibits a relatively stable spatiotemporal organization that supports brain function and can be manipulated via local brain stimulation. Such perturbations to local cortical dynamics are globally integrated by distinct…

神经元与认知 · 定量生物学 2018-01-19 Leonardo L. Gollo , James A. Roberts , Luca Cocchi

The question of controllability of natural and man-made network systems has recently received considerable attention. In the context of the human brain, the study of controllability may not only shed light into the organization and function…

最优化与控制 · 数学 2021-02-10 Tommaso Menara , Shi Gu , Danielle S. Bassett , Fabio Pasqualetti

A diverse white matter network and finely tuned neuronal membrane properties allow the brain to transition seamlessly between cognitive states. However, it remains unclear how static structural connections guide the temporal progression of…

Recent work in cognitive neuroscience has focused on analyzing the brain as a network, rather than as a collection of independent regions. Prior studies taking this approach have found that individual differences in the degree of modularity…

神经元与认知 · 定量生物学 2017-11-28 Qiuhai Yue , Randi Martin , Simon Fischer-Baum , Aurora I. Ramos-Nuñez , Fengdan Ye , Michael W. Deem

As a person learns a new skill, distinct synapses, brain regions, and circuits are engaged and change over time. In this paper, we develop methods to examine patterns of correlated activity across a large set of brain regions. Our goal is…

神经元与认知 · 定量生物学 2013-10-31 Danielle S. Bassett , Nicholas F. Wymbs , M. Puck Rombach , Mason A. Porter , Peter J. Mucha , Scott T. Grafton
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