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Electronic Health Records (EHRs) hold immense potential for advancing healthcare, offering rich, longitudinal data that combines structured information with valuable insights from unstructured clinical notes. However, the unstructured…

计算与语言 · 计算机科学 2025-01-31 Huaiyuan Ying , Hongyi Yuan , Jinsen Lu , Zitian Qu , Yang Zhao , Zhengyun Zhao , Isaac Kohane , Tianxi Cai , Sheng Yu

The primary analysis of clinical trials in diabetes therapeutic area often involves a mixed-model repeated measure (MMRM) approach to estimate the average treatment effect for longitudinal continuous outcome, and a generalized linear mixed…

应用统计 · 统计学 2022-08-03 Lingjing Jiang , Michael Rosenblum , Yu Du

This paper presents a weighted optimization framework that unifies the binary,multi-valued, continuous, as well as mixture of discrete and continuous treatment, under the unconfounded treatment assignment. With a general loss function, the…

计量经济学 · 经济学 2018-08-20 Chunrong Ai , Oliver Linton , Kaiji Motegi , Zheng Zhang

It is a common practice in randomized clinical trials with the standard survival outcome to follow patients until a prespecified number of events have been observed, a type of trial known as the event-driven trial. The event-driven design…

统计方法学 · 统计学 2026-02-10 Jingwen Zhang , Satoshi Hattori

The concept of care pathways is increasingly being used to enhance the quality of care and to optimize the use of resources for health care. Nevertheless, recommendations regarding the sequence of care are mostly based on consensus-based…

统计方法学 · 统计学 2022-09-12 Laura Savaré , Francesca Ieva , Giovanni Corrao , Antonio Lora

Background: As empirical software engineering evolves, more studies adopt data strategies$-$approaches that investigate digital artifacts such as models, source code, or system logs rather than relying on human subjects. Synthesizing…

Recently, there has been great interest in estimating the conditional average treatment effect using flexible machine learning methods. However, in practice, investigators often have working hypotheses about effect heterogeneity across…

统计方法学 · 统计学 2023-09-13 Chan Park , Hyunseung Kang

In causal inference, a variety of causal effect estimands have been studied, including the sample, uncensored, target, conditional, optimal subpopulation, and optimal weighted average treatment effects. Ad-hoc methods have been developed…

统计方法学 · 统计学 2019-10-18 Nathan Kallus , Michele Santacatterina

Increasing the success rate of a process, i.e. the percentage of cases that end in a positive outcome, is a recurrent process improvement goal. At runtime, there are often certain actions (a.k.a. treatments) that workers may execute to lift…

Event simulation for electron neutrino interactions plays a foundational role in precision measurements in particle physics experiments, yet the computational demand of traditional Monte Carlo methods remains a significant challenge,…

高能物理 - 唯象学 · 物理学 2026-04-21 Dipthi S. , Kalyani Desikan

There has been a lot of recent interest in mining patterns from graphs. Often, the exact structure of the patterns of interest is not known. This happens, for example, when molecular structures are mined to discover fragments useful as…

数据结构与算法 · 计算机科学 2007-05-23 Pavel Dmitriev , Carl Lagoze

In recent decades, event studies have emerged as a central methodology in health and social research for evaluating the causal effects of staggered interventions. In this paper, we analyze event studies from experimental design principles…

统计方法学 · 统计学 2024-11-25 Zhu Shen , Ambarish Chattopadhyay , Yuzhou Lin , Jose R. Zubizarreta

Sequential effect systems are a class of effect system that exploits information about program order, rather than discarding it as traditional commutative effect systems do. This extra expressive power allows effect systems to reason about…

编程语言 · 计算机科学 2020-05-18 Colin S. Gordon

Process models may be automatically generated from event logs that contain as-is data of a business process. While such models generalize over the control-flow of specific, recorded process executions, they are often also annotated with…

Complex software systems evolve frequently, e.g., when introducing new features or fixing bugs during maintenance. However, understanding the impact of such changes on system behavior is often difficult. Many approaches have thus been…

软件工程 · 计算机科学 2020-01-09 Thomas Krismayer , Michael Vierhauser , Rick Rabiser , Paul Grünbacher

Although understanding and characterizing causal effects have become essential in observational studies, it is challenging when the confounders are high-dimensional. In this article, we develop a general framework $\textit{CausalEGM}$ for…

机器学习 · 统计学 2023-03-20 Qiao Liu , Zhongren Chen , Wing Hung Wong

We develop the "generalized consistent weighted sampling" (GCWS) for hashing the "powered-GMM" (pGMM) kernel (with a tuning parameter $p$). It turns out that GCWS provides a numerically stable scheme for applying power transformation on the…

机器学习 · 统计学 2022-01-10 Ping Li , Weijie Zhao

Resolution of complex post-production issues in large-scale open-source software (OSS) projects requires significant cognitive effort, as developers need to go through long, unstructured and fragmented issue discussion threads before that.…

软件工程 · 计算机科学 2026-04-29 Nazia Shehnaz Joynab , Soneya Binta Hossain

Event extraction is challenging due to the complex structure of event records and the semantic gap between text and event. Traditional methods usually extract event records by decomposing the complex structure prediction task into multiple…

计算与语言 · 计算机科学 2021-06-18 Yaojie Lu , Hongyu Lin , Jin Xu , Xianpei Han , Jialong Tang , Annan Li , Le Sun , Meng Liao , Shaoyi Chen

Context: Forgetting is defined as a gradual process of losing information. Even though there are many studies demonstrating the effect of forgetting in software development, to the best of our knowledge, no study explores the impact of…

软件工程 · 计算机科学 2022-04-19 Utku Ünal , Eray Tüzün , Tamer Gezici , Ausaf Ahmed Farooqui