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Alzheimer's disease is one of the diseases that mostly affects older people without being a part of aging. The most common symptoms include problems with communicating and abstract thinking, as well as disorientation. It is important to…

图像与视频处理 · 电气工程与系统科学 2020-12-01 Fatih Altay , Guillermo Ramon Sanchez , Yanli James , Stephen V. Faraone , Senem Velipasalar , Asif Salekin

Medical brain image analysis is a necessary step in Computer Assisted /Aided Diagnosis (CAD) systems. Advancements in both hardware and software in the past few years have led to improved segmentation and classification of various diseases.…

图像与视频处理 · 电气工程与系统科学 2021-01-15 Darwin Castillo , Vasudevan Lakshminarayanan , Maria J. Rodriguez-Alvarez

Alzheimer's disease (AD) is associated with local (e.g. brain tissue atrophy) and global brain changes (loss of cerebral connectivity), which can be detected by high-resolution structural magnetic resonance imaging. Conventionally, these…

机器学习 · 计算机科学 2021-05-11 Sarah C. Brüningk , Felix Hensel , Catherine R. Jutzeler , Bastian Rieck

Precision analysis of galaxy-galaxy strong gravitational lensing images provides a unique way of characterizing small-scale dark matter halos, and could allow us to uncover the fundamental properties of dark matter's constituents. Recently,…

宇宙学与河外天体物理 · 物理学 2022-11-15 Noemi Anau Montel , Adam Coogan , Camila Correa , Konstantin Karchev , Christoph Weniger

Unsupervised anomaly detection in brain imaging is challenging. In this paper, we propose self-supervised masked mesh learning for unsupervised anomaly detection on 3D cortical surfaces. Our framework leverages the intrinsic geometry of the…

图像与视频处理 · 电气工程与系统科学 2025-04-01 Hao-Chun Yang , Sicheng Dai , Saige Rutherford , Christian Gaser , Andre F Marquand , Christian F Beckmann , Thomas Wolfers

Research question: This study aims to find whether other neurostructural measurements could be added and combined with the state-of-the-art Alzheimer's imaging marker called MSSM to improve sensitivity to neurodegeneration in Alzheimer's…

神经元与认知 · 定量生物学 2024-09-24 Jinhee Jang , Geonwoo Baek , Ikbeom Jang

Deep learning has shown outstanding performance in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated…

图像与视频处理 · 电气工程与系统科学 2019-08-22 Taeho Jo , Kwangsik Nho , Andrew J. Saykin

Accurate estimation of shape thickness from medical images is crucial in clinical applications. For example, the thickness of myocardium is one of the key to cardiac disease diagnosis. While mathematical models are available to obtain…

图像与视频处理 · 电气工程与系统科学 2020-08-26 Qiaoying Huang , Eric Z. Chen , Hanchao Yu , Yimo Guo , Terrence Chen , Dimitris Metaxas , Shanhui Sun

Multi-modal biological, imaging, and neuropsychological markers have demonstrated promising performance for distinguishing Alzheimer's disease (AD) patients from cognitively normal elders. However, it remains difficult to early predict when…

计算机视觉与模式识别 · 计算机科学 2019-01-08 Hongming Li , Yong Fan

Parkinson's disease (PD), a neurodegenerative disorder, often manifests as speech and voice dysfunction. While utilizing voice data for PD detection has great potential in clinical applications, the widely used deep learning models…

机器学习 · 计算机科学 2023-09-26 Yicheng Wang , Xiaotian Han , Leisheng Yu , Na Zou

We introduce a novel framework for the classification of functional data supported on nonlinear, and possibly random, manifold domains. The motivating application is the identification of subjects with Alzheimer's disease from their…

统计方法学 · 统计学 2024-04-15 Eardi Lila , Wenbo Zhang , Swati Rane Levendovszky

In the human brain, essential iron molecules for proper neurological functioning exist in transferrin (tf) and ferritin (Fe3) forms. However, its unusual increment manifests iron overload, which reacts with hydrogen peroxide. This reaction…

神经元与认知 · 定量生物学 2022-11-10 Shradha Verma , Tripti Goel , M Tanveer

Volumetric neuroimaging examinations like structural Magnetic Resonance Imaging (sMRI) are routinely applied to support the clinical diagnosis of dementia like Alzheimer's Disease (AD). Neuroradiologists examine 3D sMRI to detect and…

计算机视觉与模式识别 · 计算机科学 2024-07-23 Lisa Anita De Santi , Jörg Schlötterer , Meike Nauta , Vincenzo Positano , Christin Seifert

Introduction: Quantitative Susceptibility Mapping (QSM) is generally acquired with full brain coverage, even though many QSM brain-iron studies focus on the deep grey matter (DGM) region only. Reducing the spatial coverage to the DGM…

定量方法 · 定量生物学 2021-06-02 Xuanyu Zhu , Yang Gao , Feng Liu , Stuart Crozier , Hongfu Sun

Early detection is crucial to prevent the progression of Alzheimer's disease (AD). Thus, specialists can begin preventive treatment as soon as possible. They demand fast and precise assessment in the diagnosis of AD in the earliest and…

Alzheimer's disease (AD) progresses through distinct stages, from early mild cognitive impairment (EMCI) to late mild cognitive impairment (LMCI) and eventually to AD. Accurate identification of these stages, especially distinguishing LMCI…

计算机视觉与模式识别 · 计算机科学 2025-01-13 Aswini Kumar Patra , Soraisham Elizabeth Devi , Tejashwini Gajurel

This paper introduces a novel multimodal and high-resolution human brain cerebellum lobule segmentation method. Unlike current tools that operate at standard resolution ($1 \text{ mm}^{3}$) or using mono-modal data, the proposed method…

High-dimensional neuroimaging data presents challenges for assessing neurodegenerative diseases due to complex non-linear relationships. Variational Autoencoders (VAEs) can encode scans into lower-dimensional latent spaces capturing…

Schizophrenia is a debilitating, chronic mental disorder that significantly impacts an individual's cognitive abilities, behavior, and social interactions. It is characterized by subtle morphological changes in the brain, particularly in…

计算机视觉与模式识别 · 计算机科学 2024-09-04 Nagur Shareef Shaik , Teja Krishna Cherukuri , Vince Calhoun , Dong Hye Ye