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Building mathematical models of brains is difficult because of the sheer complexity of the problem. One potential starting point is through basal cognition, which gives abstract representation of a range of organisms without central nervous…

神经元与认知 · 定量生物学 2024-11-08 Linnéa Gyllingberg , Yu Tian , David J. T. Sumpter

Feedback can be utilized to convert information into useful work, making it an effective tool for increasing the performance of thermodynamic engines. Using feedback reversibility as a guiding principle, we devise a method for designing…

统计力学 · 物理学 2015-06-03 Jordan M. Horowitz , Juan M. R. Parrondo

Can a micron sized sack of interacting molecules understand, and adapt to a constantly-fluctuating environment? Cellular life provides an existence proof in the affirmative, but the principles that allow for life's existence are far from…

分子网络 · 定量生物学 2022-05-16 William Poole , Thomas Ouldridge , Manoj Gopalkrishnan , Erik Winfree

The importance of low power consumption is widely acknowledged due to the increasing use of portable devices, which require minimizing the consumption of energy. The energy in a computational system depends heavily on the software being…

适应与自组织系统 · 物理学 2024-04-15 Kostas Zotos , Andreas Litke , Alexander Chatzigeorgiou , Spyros Nikolaidis , George Stephanides

Life relies on a sophisticated metabolic molecular machinery that turns over high-energy molecules to evolve complex macromolecules and assemblies. At the molecular origin of life, such machinery was absent, implying the need for simple yet…

化学物理 · 物理学 2025-10-14 Pranay Jaiswal , Ivar S. Haugerud , Hidde D. Vuijk , Christoph A. Weber

Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can cells be optimally efficient, and if not, why? We show that,…

分子网络 · 定量生物学 2017-04-12 Thomas E. Ouldridge , Christopher C. Govern , Pieter Rein ten Wolde

Despite the obvious advantage of simple life forms capable of fast replication, different levels of cognitive complexity have been achieved by living systems in terms of their potential to cope with environmental uncertainty. Against the…

种群与进化 · 定量生物学 2017-10-18 Luís F Seoane , Ricard Solé

We study experimentally work fluctuations in a Szilard engine that extracts work from information encoded as the occupancy of an electron level in a semiconductor quantum dot. We show that as the average work extracted per bit of…

Modeling biological processes is a highly demanding task because not all processes are fully understood. Mathematical models allow us to test hypotheses about possible mechanisms of biological processes. The mathematical mechanisms…

数值分析 · 数学 2023-12-11 Cordula Reisch , Hannah Burmester

Exascale computing holds great opportunities for molecular dynamics (MD) simulations. However, to take full advantage of the new possibilities, we must learn how to focus computational power on the discovery of complex molecular mechanisms,…

化学物理 · 物理学 2019-01-16 Hendrik Jung , Roberto Covino , Gerhard Hummer

Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can cells be optimally efficient, and if not, why? We show that,…

统计力学 · 物理学 2017-04-19 Thomas E. Ouldridge , Pieter Rein ten Wolde

In thermodynamics, an agent's ability to extract work is fundamentally constrained by their environment. Traditional frameworks struggle to capture how strategic decision-making under uncertainty, particularly an agent's tolerance for risk,…

量子物理 · 物理学 2025-10-24 Maite Arcos , Philippe Faist , Takahiro Sagawa , Jonathan Oppenheim

The problem of statistical inference in its various forms has been the subject of decades-long extensive research. Most of the effort has been focused on characterizing the behavior as a function of the number of available samples, with far…

机器学习 · 计算机科学 2024-11-12 Tomer Berg , Or Ordentlich , Ofer Shayevitz

Many statistical models have high accuracy on test benchmarks, but are not explainable, struggle in low-resource scenarios, cannot be reused for multiple tasks, and cannot easily integrate domain expertise. These factors limit their use,…

计算与语言 · 计算机科学 2021-09-29 Andrew Lee , Jonathan K. Kummerfeld , Lawrence C. An , Rada Mihalcea

Embedded systems become more and more widespread, especially autonomous ones, and clearly tend to be ubiquitous. In such systems, low-power and low-energy usage get ever more crucial. Furthermore, these issues also become paramount in…

编程语言 · 计算机科学 2007-05-23 Olivier Zendra

A central challenge in climate science and applied mathematics is developing data-driven models of multiscale systems that capture both stationary statistics and responses to external perturbations. Current neural climate emulators aim to…

混沌动力学 · 物理学 2026-01-27 Fabrizio Falasca

The field of artificial intelligence faces significant challenges in achieving both biological plausibility and computational efficiency, particularly in visual learning tasks. Current artificial neural networks, such as convolutional…

机器学习 · 计算机科学 2024-09-27 Jacobo Ruiz , Manas Gupta

Thermodynamics establishes that information acquired through measurement can be converted into work, as exemplified by Maxwell's demon and Szilard engines. Most experimental realizations of information engines, however, implicitly assume…

软凝聚态物质 · 物理学 2026-03-09 Lokesh Muruga , Felix Ginot , Sarah A. M. Loos , Clemens Bechinger

Combining a spatiotemporal, multi-agent based model of a foraging ecosystem with linear, genetically programmed rules for the agents' behaviors results in implicit, endogenous, objective functions and selection algorithms based on "natural…

神经与进化计算 · 计算机科学 2023-06-01 John C Stevenson

Complex systems are fascinating because their rich macroscopic properties emerge from the interaction of many simple parts. Understanding the building principles of these emergent phenomena in nature requires assessing natural complex…

神经元与认知 · 定量生物学 2022-11-17 Anna Levina , Viola Priesemann , Johannes Zierenberg