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Judea Pearl's insight that, when errors are assumed independent, the Pure (aka Natural) Direct Effect (PDE) is non-parametrically identified via the Mediation Formula was `path-breaking' in more than one sense! In the same paper Pearl…

统计方法学 · 统计学 2021-08-31 James M. Robins , Thomas S. Richardson , Ilya Shpitser

Adjusting for covariates is a well established method to estimate the total causal effect of an exposure variable on an outcome of interest. Depending on the causal structure of the mechanism under study there may be different adjustment…

统计理论 · 数学 2021-04-27 Jack Kuipers , Giusi Moffa

Transported mediation effects may contribute to understanding how and why interventions may work differently when applied to new populations. However, we are not aware of any estimators for such effects. Thus, we propose several different…

统计方法学 · 统计学 2020-06-16 Kara E Rudolph , Jonathan Levy , Mark J van der Laan

Outcome-dependent sampling designs are common in many different scientific fields including epidemiology, ecology, and economics. As with all observational studies, such designs often suffer from unmeasured confounding, which generally…

统计方法学 · 统计学 2020-10-13 Erin E. Gabriel , Michael C. Sachs , Arvid Sjölander

Researchers are often challenged with assessing the impact of an intervention on an outcome of interest in situations where the intervention is non-randomised, the intervention is only applied to one or few units, the intervention is…

In the social and health sciences, researchers often make causal inferences using sensitive variables. These researchers, as well as the data holders themselves, may be ethically and perhaps legally obligated to protect the confidentiality…

统计方法学 · 统计学 2024-08-28 Sharmistha Guha , Jerome P. Reiter

Assessing the causal effects of interventions on ordinal outcomes is an important objective of many educational and behavioral studies. Under the potential outcomes framework, we can define causal effects as comparisons between the…

统计方法学 · 统计学 2018-04-06 Jiannan Lu , Peng Ding , Tirthankar Dasgupta

Meta-analysis is commonly used to combine results from multiple clinical trials, but traditional meta-analysis methods do not refer explicitly to a population of individuals to whom the results apply and it is not clear how to use their…

The weighted controlled direct effect (WCDE) generalizes the standard controlled direct effect (CDE) by averaging over the mediator distribution, providing a robust estimate when treatment effects vary across mediator levels. This makes the…

统计方法学 · 统计学 2026-02-09 Ruiyang Lin , Yongyi Guo , Kyra Gan

Inferring causal relationships from observational data is often challenging due to endogeneity. This paper provides new identification results for causal effects of discrete, ordered and continuous treatments using multiple binary…

计量经济学 · 经济学 2024-10-21 Nadja van 't Hoff

In this paper, we introduce the direct potential outcome system as a framework for analyzing dynamic causal effects of assignments on outcomes in observational time series settings. We provide conditions under which common predictive time…

计量经济学 · 经济学 2025-01-23 Ashesh Rambachan , Neil Shephard

We propose an empirically stable and asymptotically efficient covariate-balancing approach to the problem of estimating survival causal effects in data with conditionally-independent censoring. This addresses a challenge often encountered…

Causal inference on multiple non-independent outcomes raises serious challenges, because multivariate techniques that properly account for the outcome's dependence structure need to be considered. We focus on the case of binary outcomes…

统计方法学 · 统计学 2018-05-11 Monia Lupparelli , Alessandra Mattei

This paper considers the practically important case of nonparametrically estimating heterogeneous average treatment effects that vary with a limited number of discrete and continuous covariates in a selection-on-observables framework where…

计量经济学 · 经济学 2019-08-26 Michael Zimmert , Michael Lechner

A key challenge in estimating causal effects from observational data is handling confounding and is commonly achieved through weighting methods that balance distribution of covariates between treatment and control groups. Weighting…

统计方法学 · 统计学 2025-12-23 Simion De , Jared D. Huling

In biomedical research, repeated measurements within each subject are often processed to remove artifacts and unwanted sources of variation. The resulting data are used to construct derived outcomes that act as proxies for scientific…

统计方法学 · 统计学 2026-02-03 Zihang Wang , Razieh Nabi , Benjamin B. Risk

We examine the problem of causal response estimation for complex objects (e.g., text, images, genomics). In this setting, classical \emph{atomic} interventions are often not available (e.g., changes to characters, pixels, DNA base-pairs).…

机器学习 · 计算机科学 2021-06-11 Limor Gultchin , David S. Watson , Matt J. Kusner , Ricardo Silva

Researchers are often interested in learning not only the effect of treatments on outcomes, but also the pathways through which these effects operate. A mediator is a variable that is affected by treatment and subsequently affects outcome.…

统计方法学 · 统计学 2021-12-22 Jeremiah Jones , Ashkan Ertefaie , Robert L. Strawderman

The proximal causal inference framework enables the identification and estimation of causal effects in the presence of unmeasured confounding by leveraging two disjoint sets of observed strong proxies: negative control treatments and…

统计方法学 · 统计学 2025-12-16 Antonio Olivas-Martinez , Peter B. Gilbert , Andrea Rotnitzky

Causal inference in observational studies can be challenging when confounders are subject to missingness. Generally, the identification of causal effects is not guaranteed even under restrictive parametric model assumptions when confounders…

统计方法学 · 统计学 2023-03-23 Jian Sun , Bo Fu