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In this work, we developed and evaluated a novel pipeline consisting of two landmark-based field aperture generation approaches for WBRT treatment planning; they are fully automated and customizable. The automation pipeline is beneficial…

Temporal point processes (TPPs) are a fundamental tool for modeling event sequences in continuous time, but most existing approaches rely on autoregressive parameterizations that are limited by their sequential sampling. Recent…

机器学习 · 计算机科学 2026-02-05 David Lüdke , Marten Lienen , Marcel Kollovieh , Stephan Günnemann

Purpose: To evaluate automated multicriteria optimization (MCO)-- designed for intensity modulated radiation therapy (IMRT), but invoked with limited segmentation -- to efficiently produce high quality 3D conformal treatment (3D-CRT) plans.…

医学物理 · 物理学 2014-02-03 Fazal Khan , David Craft

Clinical case reports and discharge summaries may be the most complete and accurate summarization of patient encounters, yet they are finalized, i.e., timestamped after the encounter. Complementary structured data streams become available…

计算与语言 · 计算机科学 2026-05-13 Shahriar Noroozizadeh , Jeremy C. Weiss

The steep dose gradients obtained with pencil beam scanning allow for precise tumor targeting at the cost of high sensitivity to uncertainties. Robust optimization is commonly applied to mitigate uncertainties in density and patient setup,…

医学物理 · 物理学 2024-11-26 Ivar Bengtsson , Anders Forsgren , Albin Fredriksson , Ye Zhang

Traditional approaches to financial asset allocation start with returns forecasting followed by an optimization stage that decides the optimal asset weights. Any errors made during the forecasting step reduce the accuracy of the asset…

投资组合管理 · 定量金融 2022-06-08 Damian Kisiel , Denise Gorse

A wide range of astrophysical sources exhibit extreme and rapidly varying electromagnetic emission indicative of efficient non-thermal particle acceleration. Understanding these sources often involves comparing data with a broad range of…

高能天体物理现象 · 物理学 2024-11-27 Zachary Davis , Jesús M. Rueda-Becerril , Dimitrios Giannios

External beam X-ray therapy (XRT) and proton therapy (PT) are effective and widely accepted forms of treatment for many types of cancer. However, the procedures require extensive computerized planning. Current planning systems for both XRT…

图形学 · 计算机科学 2018-11-30 Felix G. Hamza-Lup , Shane Farrar , Erik Leon

We present an open-source platform to aid medical dosimetrists in preventing collisions between gantry head and patient or couch during photon or particle beam therapy treatment planning. This generic framework uses the native scripting…

医学物理 · 物理学 2021-09-02 F Hueso-González , P Wohlfahrt , D Craft , K Remillard

Modern zero-shot text-to-speech (TTS) systems, despite using extensive pre-training, often struggle in challenging scenarios such as tongue twisters, repeated words, code-switching, and cross-lingual synthesis, leading to intelligibility…

声音 · 计算机科学 2025-06-09 Xueyao Zhang , Yuancheng Wang , Chaoren Wang , Ziniu Li , Zhuo Chen , Zhizheng Wu

Context: Utilization of operating theaters is a major cost driver in hospitals. Optimizing this variable through optimized surgery schedules may significantly lower cost and simultaneously improve medical outcomes. Previous studies proposed…

应用统计 · 统计学 2025-09-05 Harald Störrle , Anastasia Hort

Uncompressed clinical data from modern positron emission tomography (PET) scanners are very large, exceeding 350 million data points (projection bins). The last decades have seen tremendous advancements in mathematical imaging tools many of…

医学物理 · 物理学 2020-01-08 Matthias J. Ehrhardt , Pawel Markiewicz , Carola-Bibiane Schönlieb

Hospital readmission prediction is critical for clinical decision support, aiming to identify patients at risk of returning within 30 days post-discharge. High readmission rates often indicate inadequate treatment or post-discharge care,…

机器学习 · 计算机科学 2024-12-18 Zhenyi Fan , Jiaqi Li , Dongyu Luo , Yuqi Yuan

While loop reordering and fusion can make big impacts on the constant-factor performance of dense tensor programs, the effects on sparse tensor programs are asymptotic, often leading to orders of magnitude performance differences in…

数学软件 · 计算机科学 2023-10-13 Willow Ahrens , Fredrik Kjolstad , Saman Amarasinghe

A treatment regime is a deterministic function that dictates personalized treatment based on patients' individual prognostic information. There is a fast-growing interest in finding optimal treatment regimes to maximize expected long-term…

统计理论 · 数学 2016-11-25 Runchao Jiang , Wenbin Lu , Rui Song , Marie Davidian

The high precision and conformity of intensity-modulated particle therapy (IMPT) comes at the cost of susceptibility to treatment uncertainties in particle range and patient set-up. Dose uncertainty quantification and mitigation, which is…

医学物理 · 物理学 2021-11-17 Pia Stammer , Lucas Burigo , Oliver Jäkel , Martin Frank , Niklas Wahl

We present a method of directly optimizing on deviations in clinical goal values in radiation therapy treatment planning. Using a new mathematical framework in which metrics derived from the dose-volume histogram are regarded as functionals…

医学物理 · 物理学 2021-09-07 Tianfang Zhang , Rasmus Bokrantz , Jimmy Olsson

Neural text-to-speech (TTS) models can synthesize natural human speech when trained on large amounts of transcribed speech. However, collecting such large-scale transcribed data is expensive. This paper proposes an unsupervised pre-training…

音频与语音处理 · 电气工程与系统科学 2023-03-29 Seongyeon Park , Myungseo Song , Bohyung Kim , Tae-Hyun Oh

Applications' performance is influenced by the mapping of processes to computing nodes, the frequency and volume of exchanges among processing elements, the network capacity, and the routing protocol. A poor mapping of application processes…

分布式、并行与集群计算 · 计算机科学 2021-03-11 Jonas H. Müller Korndörfer , Mario Bielert , Laércio L. Pilla , Florina M. Ciorba

Recent years, many applications have been driven advances by the use of Machine Learning (ML). Nowadays, it is common to see industrial-strength machine learning jobs that involve millions of model parameters, terabytes of training data,…

数据库 · 计算机科学 2020-08-05 Chris Liu , Pengfei Zhang , Bo Tang , Hang Shen , Lei Zhu , Ziliang Lai , Eric Lo