相关论文: Computational study of geometric effects of bottom…
Microorganisms, such as bacteria and microalgae, often live in habitats consisting of a liquid phase and a plethora of interfaces. The precise ways in which these motile microbes behave in their confined environment remain unclear. Using…
An experimental study is combined with numerical modelling to investigate new ways to reduce cross-flow vibrations of hydraulic gates with underflow. A rectangular gate section placed in a flume was given freedom to vibrate in the vertical…
Condensed water on vertical surfaces ultimately leaves the substrate at the lower edge, where accumulated liquid detaches as drops. While droplet growth and surface transport have been extensively studied, this final release step remains…
Motivated by rolling adhesion of white blood cells in the vasculature, we study how cells move in linear shear flow above a wall to which they can adhere via specific receptor-ligand bonds. Our computer simulations are based on a Langevin…
We report the pinching of an elongated liquid droplet that is confined in a rectangular microchannel. The droplet pinching is induced by a local variation of the channel topography and can lead to its break-up. The modification of the…
Microfluidic channels are integral to biomedical technology and process engineering, offering versatility in handling fluids with complex properties, often a combination of viscous and elastic attributes. Despite significant advancements in…
The mechanosensitivity of cells, which determines how they are able to respond to mechanical signals received from their environment, is crucial for the functioning of all biological systems. In experiments, cells placed on cyclically…
Many closed-cell foams exhibit an elongated cell shape in the foam rise direction, resulting in anisotropic compressive properties. Nevertheless, the underlying deformation mechanisms and how cell shape anisotropy induces this mechanical…
Flow-matching generative models are increasingly used to simulate cell responses to biological perturbations. However, the design space for building such models is large and underexplored. We systematically analyse the design space of flow…
Microorganisms navigate through fluid, often confined by complex environments, to survive and sustain life. Inspired by this fact, we consider a model system and seek to understand the wall curvature driven dynamics of a squirmer, a…
The ability of eukaryotic cells to squeeze through constrictions is limited by the stiffness of their large and rigid nucleus. However, migrating cells are often able to overcome this limitation and pass through constrictions much smaller…
Recently, experiments showed that forces on intruders dragged horizontally through dense, hydrostatic granular packings mainly depend on the local surface orientation and can be seen as the sum of the forces exerted on small surface…
The slow flow of amorphous solids exhibits striking heterogeneities: swift localised particle rearrangements take place in the midst of a more or less homogeneously deforming medium. Recently, experimental as well as numerical work has…
The extra-cellular microenvironment has a fundamental role in tumor growth and progression, strongly affecting the migration strategies adopted by single cancer cells during metastatic invasion. In this study, we use a novel microfluidic…
Living cells respond to mechanical changes in the matrix surrounding them by applying contractile forces that are in turn transmitted to distant cells. We calculate the mechanical work that each cell performs in order to deform the matrix,…
As motivated by studies of cellular motility driven by spatiotemporal chemotactic gradients in microdevices, we develop a framework for constructing approximate analytical solutions for the location, speed and cellular densities for cell…
Stress transmission in realistic granular media often occurs under external load and in the presence of boundary slip. We investigate shear localization in a split-bottom Couette cell with smooth walls subject to a confining pressure…
Interactions between fluids and granular materials are prevalent on the Earth's surface. In the case of fluid flow over a sediment bed, the fluid imparts a shear stress to the granular materials. When the applied shear stress is above a…
Open cell foams have diverse industrial applications e.g. heat exchangers, structured reactors, filtration due to their unique properties such as high porosity and high specific surface area. In order to theoretically determine the…
The transport of bio-particles in viscous flows exhibits a rich variety of dynamical behaviour, such as morphological transitions, complex orientation dynamics or deformations. Characterising such complex behaviour under well controlled…