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Since its foundations, more than one hundred years ago, the field of structural biology has strived to understand and analyze the properties of molecules and their interactions by studying the structure that they take in 3D space. However,…

生物大分子 · 定量生物学 2023-02-27 Gabriele Corso

We introduce a model for describing the dynamics of large numbers of interacting cells. The fundamental dynamical variables in the model are sub-cellular elements, which interact with each other through phenomenological intra- and…

定量方法 · 定量生物学 2007-05-23 T. J. Newman

Spatial transcriptomics methods capture cellular measurements such as gene expression and cell types at specific locations in a cell, helping provide a localized picture of tissue health. Traditional visualization techniques superimpose the…

定量方法 · 定量生物学 2024-10-16 Siyuan Zhao , G. Elisabeta Marai

Molecular representation is a critical element in our understanding of the physical world and the foundation for modern molecular machine learning. Previous molecular machine learning models have employed strings, fingerprints, global…

Although continuous advances in theoretical modelling of Molecular Communications (MC) are observed, there is still an insuperable gap between theory and experimental testbeds, especially at the microscale. In this paper, the development of…

Single molecule detection has revolutionised the fields of chemistry and biology by offering powerful ways to study individual molecules under different scenarios. Nanophotonic structures, including plasmonic antennas, significantly…

Information delivery using chemical molecules is an integral part of biology at multiple distance scales and has attracted recent interest in bioengineering and communication. The collective signal strength at the receiver (i.e., the…

信息论 · 计算机科学 2016-08-04 Yansha Deng , Adam Noel , Weisi Guo , Arumugam Nallanathan , Maged Elkashlan

Our work is concerned with the generation and targeted design of RNA, a type of genetic macromolecule that can adopt complex structures which influence their cellular activities and functions. The design of large scale and complex…

生物大分子 · 定量生物学 2021-02-02 Zichao Yan , William L. Hamilton , Mathieu Blanchette

This work presents a new multi-chemical experimental platform for molecular communication where the transmitter can release different chemicals. This platform is designed to be inexpensive and accessible, and it can be expanded to simulate…

新兴技术 · 计算机科学 2017-04-18 Nariman Farsad , David Pan , Andrea Goldsmith

Multifunctional nanomaterials combining diagnosis and therapeutic properties have attracted a considerable attention in cancer research. Yet some important challenges are still to be faced, including an optimal coupling between these two…

生物物理 · 物理学 2019-10-31 Yupeng Shi , Flavien Guenneau , Xiaolin Wang , Christophe Hélary , Thibaud Coradin

Data-driven cell tracking and segmentation methods in biomedical imaging require diverse and information-rich training data. In cases where the number of training samples is limited, synthetic computer-generated data sets can be used to…

计算机视觉与模式识别 · 计算机科学 2023-10-16 David Wiesner , Julian Suk , Sven Dummer , Tereza Nečasová , Vladimír Ulman , David Svoboda , Jelmer M. Wolterink

Controlled drug delivery (CDD), the controlled release and delivery of therapeutic drugs inside the human body, is a promising approach to increase the efficacy of drug administration and reduce harmful side effects to the body. CDD has…

信号处理 · 电气工程与系统科学 2023-05-11 Sebastian Lotter , Tom Bellmann , Sophie Marx , Mara Wesinger , Lukas Brand , Maximilian Schäfer , Dagmar Fischer , Robert Schober

The analysis of electrophysiological data is crucial for certain surgical procedures such as deep brain stimulation, which has been adopted for the treatment of a variety of neurological disorders. During the procedure, auditory analysis of…

机器学习 · 计算机科学 2025-03-24 Thibault Martin , Paul Sauleau , Claire Haegelen , Pierre Jannin , John S. H. Baxter

Molecular Communication (MC) is an emerging field of research focused on understanding how cells in the human body communicate and exploring potential medical applications. In theoretical analysis, the goal is to investigate cellular…

信息论 · 计算机科学 2025-12-19 Wafa Labidi , Vida Gholamian , Yaning Zhao , Christian Deppe , Holger Boche

Microfluidic droplet screens serve as an innovative platform for high-throughput biotechnology, enabling significant advancements in discovery, product optimization, and analysis. This review sheds light on the emerging trend of interaction…

定量方法 · 定量生物学 2023-09-11 Carolus Vitalis , Tobias Wenzel

In biological cells and novel diagnostic devices biochemical receptors need to be sensitive to extremely small concentration changes of signaling molecules. The accuracy of such molecular signaling is ultimately limited by the counting…

亚细胞过程 · 定量生物学 2023-04-06 Aljaz Godec , Ralf Metzler

Single-cell RNA sequencing (scRNA-seq), especially temporally resolved datasets, enables genome-wide profiling of gene expression dynamics at single-cell resolution across discrete time points. However, current technologies provide only…

基因组学 · 定量生物学 2025-11-19 Yue Ling , Peiqi Zhang , Zhenyi Zhang , Peijie Zhou

This paper investigates a coordinated multi-cell integrated sensing, communication, and powering (ISCAP) system operating in the electromagnetic near field, where each base station (BS) employs an extremely large-scale antenna array (ELAA)…

网络与互联网体系结构 · 计算机科学 2026-01-06 Yuan Guo , Yilong Chen , Zixiang Ren , Derrick Wing Kwan Ng , Jie Xu

In this article, we present a real-time three dimensional (3D) hybrid beamforming for fifth generation (5G) wireless networks. One of the key concepts in 5G cellular systems is the small cell network, which settles the high mobile traffic…

Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an…