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Living soft tissues appear to promote the development and maintenance of a preferred mechanical state within a defined tolerance around a so-called set-point. This phenomenon is often referred to as mechanical homeostasis. In contradiction…

计算工程、金融与科学 · 计算机科学 2021-09-23 Jonas F. Eichinger , Maximilian J. Grill , Iman Davoodi Kermani , Roland C. Aydin , Wolfgang A. Wall , Jay D. Humphrey , Christian J. Cyron

Linear dynamical systems are canonical models for learning-based control of plants with uncertain dynamics. The setting consists of a stochastic differential equation that captures the state evolution of the plant understudy, while the true…

系统与控制 · 电气工程与系统科学 2022-01-03 Mohamad Kazem Shirani Faradonbeh , Mohamad Sadegh Shirani Faradonbeh

We investigate morphologies of proliferating cellular tissue using a newly developed numerical simulation model for mechanical cell division. The model reproduces structures of simple multi-cellular organisms via simple rules for selective…

软凝聚态物质 · 物理学 2018-11-20 Pranav Madhikar , Jan Åström , Björn Baumeier , Mikko Karttunen

During the early-stages of embryo development, morphogenesis--- the emergence of shape and form in living organisms--- is almost exclusively associated with monolayers of tightly bound epithelial cells. To understand how such tissues change…

软凝聚态物质 · 物理学 2019-08-28 Richard G. Morris , Madan Rao

In this work, a new model for macroscopic plant tissue growth based on dynamical Riemannian geometry is presented. We treat 1D and 2D tissues as continuous, deformable, growing geometries for sizes larger than 1mm. The dynamics of the…

组织与器官 · 定量生物学 2016-02-05 Julia Pulwicki

Growth pattern dynamics lie at the heart of morphogenesis. Here, we investigate the growth of plant leaves. We compute the conformal transformation that maps the contour of a leaf at a given stage onto the contour of the same leaf at a…

组织与器官 · 定量生物学 2016-11-23 Karen Alim , Shahaf Armon , Boris I. Shraiman , Arezki Boudaoud

The rheological properties of biological tissues are core to processes such as cancer metastasis, wound healing and embryo development. The emergence of tissue and organ structures during morphogenesis requires the precise formation of…

软凝聚态物质 · 物理学 2026-03-10 Aidan J. Nicholas , Suzanne M. Fielding

In biological tissues, it is now well-understood that mechanical cues are a powerful mechanism for pattern regulation. While much work has focused on interactions between cells and external substrates, recent experiments suggest that cell…

软凝聚态物质 · 物理学 2017-11-01 Michael Czajkowski , Dapeng Bi , M. Lisa Manning , M. Cristina Marchetti

The evolution of various competing cell types in tissues, and the resulting persistent tissue population, is studied numerically and analytically in a particle-based model of active tissues. Mutations change the properties of cells in…

种群与进化 · 定量生物学 2024-06-03 Tobias Büscher , Nirmalendu Ganai , Gerhard Gompper , Jens Elgeti

We study locally interacting processes in discrete time, often called probabilistic cellular automata, indexed by locally finite graphs. For infinite regular trees and certain generalized Galton-Watson trees, we show that the marginal…

概率论 · 数学 2025-10-28 Daniel Lacker , Kavita Ramanan , Ruoyu Wu

Space-saving design is a requirement that is encountered in biological systems and the development of modern technological devices alike. Many living organisms dynamically pack their polymer chains, filaments or membranes inside of…

软凝聚态物质 · 物理学 2014-07-18 Roman Vetter , Falk K. Wittel , Hans J. Herrmann

The dynamic of complex ordering systems with active rotational degrees of freedom exemplified by protein self-assembly is explored using a machine learning workflow that combines deep learning-based semantic segmentation and rotationally…

In this paper, we analyze the linear stability of a stellar accretion disk, having a stratified morphology. The study is performed in the framework of ideal magneto-hydrodynamics and therefore it results in a characterization of the linear…

高能天体物理现象 · 物理学 2016-01-20 G. Montani , D. Pugliese

We present some existence results for three-dimensional quasistatic morphoelasticity. The state of the growing body is described by its deformation and the underlying growth tensor and is ruled by the interplay of hyperelastic energy…

偏微分方程分析 · 数学 2021-11-23 Elisa Davoli , Katerina Nik , Ulisse Stefanelli

We derive an asymptotically consistent morphoelastic shell model to describe the finite deformations of biological tissues using the variational asymptotical method. Biological materials may exhibit remarkable compressibility when under…

软凝聚态物质 · 物理学 2024-07-23 Xiang Yu , Xiaoyi Chen

Morphogenesis of complex body shapes is reproducible despite the noise inherent in the underlying morphogenetic processes. However, how these morphogenetic processes work together to achieve this reproducibility remains unclear. Here, we…

细胞行为 · 定量生物学 2025-12-24 Dominic K Devlin , Austen RD Ganley , Nobuto Takeuchi

Flexible mechanical metamaterials possess repeating structural motifs that imbue them with novel, exciting properties including programmability, anomalous elastic moduli and nonlinear and robust response. We address such structures via…

软凝聚态物质 · 物理学 2020-03-11 Adrien Saremi , Zeb Rocklin

In multi-cellular organisms, cells differentiate into multiple types as they divide. States of these cell types, as well as their numbers, are known to be robust to external perturbations; as conceptualized by Waddington's epigenetic…

生物物理 · 物理学 2026-01-21 Davey Plugers , Kunihiko Kaneko

Cell invasion and spatial pattern formation are two distinct manifestations of cellular self-organisation in development, regeneration, and disease. Here, we develop and analyse a unified theoretical framework that links these two seemingly…

组织与器官 · 定量生物学 2026-04-30 Carles Falcó , Samuel W. S. Johnson , Mohit P. Dalwadi , Philip K. Maini

The adoption of agroecological practices will be crucial to address the challenges of climate change and biodiversity loss. Such practices favor the cultivation of plants in complex mixtures with layouts differing from the monoculture…

种群与进化 · 定量生物学 2024-09-26 Julian Talbot , Pascal Viot , David Colliaux