相关论文: Cancer Research UK Drug Discovery Process Mining
Large scale initiatives such as the Human Genome Project, Structural Genomics, and individual research teams have provided large deposits of genomic and proteomic data. The transfer of data to knowledge has become one of the existing…
We describe the current state and future plans for a set of tools for scientific data management (SDM) designed to support scientific transparency and reproducible research. SDM has been in active use at our MRI Center for more than two…
Electronic health records (EHR's) are only a first step in capturing and utilizing health-related data - the problem is turning that data into useful information. Models produced via data mining and predictive analysis profile inherited…
Drug combination therapy has become a increasingly promising method in the treatment of cancer. However, the number of possible drug combinations is so huge that it is hard to screen synergistic drug combinations through wet-lab…
Guided troubleshooting is an inherent task in the domain of technical support services. When a customer experiences an issue with the functioning of a technical service or a product, an expert user helps guide the customer through a set of…
In this research, a new data mining-based design approach has been developed for designing complex mechanical systems such as a crashworthy passenger car with uncertainty modeling. The method allows exploring the big crash simulation…
Web log data is usually diverse and voluminous. This data must be assembled into a consistent, integrated and comprehensive view, in order to be used for pattern discovery. Without properly cleaning, transforming and structuring the data…
Extra-label drug use in food animal medicine is authorized by the US Animal Medicinal Drug Use Clarification Act (AMDUCA), and estimated withdrawal intervals are based on published scientific pharmacokinetic data. Occasionally there is a…
Data preparation is the first and a very important step towards any Large Language Model (LLM) development. This paper introduces an easy-to-use, extensible, and scale-flexible open-source data preparation toolkit called Data Prep Kit…
We present a case study of Process Mining (PM) for personnel security screening in the Canadian government. We consider customer (process time) and organizational (cost) perspectives. Furthermore, in contrast to most published case studies,…
Motivation: Uncovering the genomic causes of cancer, known as cancer driver genes, is a fundamental task in biomedical research. Cancer driver genes drive the development and progression of cancer, thus identifying cancer driver genes and…
The management of health data, from their gathering to their analysis, arises a number of challenging issues due to their highly confidential nature. In particular, this dissertation contributes to several security and privacy challenges…
Process mining is a discipline which concerns the analysis of execution data of operational processes, the extraction of models from event data, the measurement of the conformance between event data and normative models, and the enhancement…
Molecular docking is an important tool for structure-based drug design, accelerating the efficiency of drug development. Complex and dynamic binding processes between proteins and small molecules require searching and sampling over a wide…
Objective: The majority of detailed patient information in real-world data (RWD) is only consistently available in free-text clinical documents. Manual curation is expensive and time-consuming. Developing natural language processing (NLP)…
Process mining discovers and analyzes a process model from historical event logs. The prior art methods use the key attributes of case-id, activity, and timestamp hidden in an event log as clues to discover a process model. However, a user…
Real life business processes change over time, in both planned and unexpected ways. The detection of these changes is crucial for organizations to ensure that the expected and the real behavior are as similar as possible. These changes over…
DGCC protocol has been shown to achieve good performance on multi-core in-memory system. However, distributed transactions complicate the dependency resolution, and therefore, an effective transaction partitioning strategy is essential to…
This paper presents DIALOG (Digital Investigation Ontology); a framework for the management, reuse, and analysis of Digital Investigation knowledge. DIALOG provides a general, application independent vocabulary that can be used to describe…
Major domains such as logistics, healthcare, and smart cities increasingly rely on sensor technologies and distributed infrastructures to monitor complex processes in real time. These developments are transforming the data landscape from…