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Accurate early diagnosis and monitoring of neurodegenerative conditions is essential for effective disease management and delivery of medication and treatment. This research develops automatic methods for detecting brain imaging preclinical…

神经与进化计算 · 计算机科学 2019-10-15 Amir Dehsarvi , Stephen L. Smith

While Parkinson's disease (PD) is typically characterized by motor disorder, there is evidence of diminished emotion perception in PD patients. This study examines the utility of affective Electroencephalography (EEG) signals to understand…

Parkinson's disease (PD), a degenerative disorder of the central nervous system, is commonly diagnosed using functional medical imaging techniques such as single-photon emission computed tomography (SPECT). In this study, we utilized two…

机器学习 · 计算机科学 2025-01-22 Guan-Hua Huang , Wan-Chen Lai , Tai-Been Chen , Chien-Chin Hsu , Huei-Yung Chen , Yi-Chen Wu , Li-Ren Yeh

Parkinson's Disease (PD) medication management presents unique challenges due to heterogeneous disease progression and treatment response. Neurologists must balance symptom control with optimal dopaminergic dosing based on functional…

机器学习 · 计算机科学 2025-08-15 Ricardo Diaz-Rincon , Muxuan Liang , Adolfo Ramirez-Zamora , Benjamin Shickel

Application and use of deep learning algorithms for different healthcare applications is gaining interest at a steady pace. However, use of such algorithms can prove to be challenging as they require large amounts of training data that…

机器学习 · 计算机科学 2020-05-08 Anirudh Som , Narayanan Krishnamurthi , Matthew Buman , Pavan Turaga

Since anatomic MRI is presently not able to directly discern neuronal loss in Parkinson's Disease (PD), studying the associated functional connectivity (FC) changes seems a promising approach toward developing non-invasive and…

神经元与认知 · 定量生物学 2018-02-07 Liviu Badea , Mihaela Onu , Tao Wu , Adina Roceanu , Ovidiu Bajenaru

Background: Parkinson's disease remains a major neurodegenerative disorder with high misdiagnosis rates, primarily due to reliance on clinical rating scales. Recent studies have demonstrated a strong association between gut microbiota and…

人工智能 · 计算机科学 2025-09-10 Bo Yu , Zhixiu Hua , Bo Zhao

Sensors from smart consumer devices have demonstrated high potential to serve as digital biomarkers in the identification of movement disorders in recent years. With the usage of broadly available smartwatches we have recorded participants…

机器学习 · 计算机科学 2022-05-12 Alexander Brenner , Michael Fujarski , Tobias Warnecke , Julian Varghese

Parkinson's disease (PD) is a chronic, degenerative neurological disorder. PD cannot be prevented, slowed or cured as of today but highly effective symptomatic treatments are available. We consider relevant estimands and treatment effect…

In this work, we explore various neural network architectures using Magnetic Resonance (MR) T1 images of the brain to identify Parkinson's Disease (PD), which is one of the most common neurodegenerative and movement disorders. We propose…

图像与视频处理 · 电气工程与系统科学 2020-07-27 Tahjid Ashfaque Mostafa , Irene Cheng

In this paper, we introduce a novel approach for diagnosis of Parkinson's Disease (PD) based on deep Echo State Networks (ESNs). The identification of PD is performed by analyzing the whole time-series collected from a tablet device during…

机器学习 · 计算机科学 2018-02-20 Claudio Gallicchio , Alessio Micheli , Luca Pedrelli

Parkinson's disease (PD) severity diagnosis is crucial for early detecting potential patients and adopting tailored interventions. Diagnosing PD based on facial expression is grounded in PD patients' "masked face" symptom and gains growing…

计算机视觉与模式识别 · 计算机科学 2025-10-22 Yintao Zhou , Wei Huang , Zhengyu Li , Jing Huang , Meng Pang

Parkinson's disease (PD) is the second most frequent neurodegenerative disease with prevalence among general population reaching 0.1-1 %, and an annual incidence between 1.3-2.0/10000 inhabitants. The mean age at diagnosis of PD is 55 and…

In this study, we executed a genomic analysis with the objective of selecting a set of genes (possibly small) that would help in the detection and classification of samples from patients affected by Parkinson Disease. We performed a…

机器学习 · 计算机科学 2016-02-24 Giancarlo Crocetti , Michael Coakley , Phil Dressner , Wanda Kellum , Tamba Lamin

Accurate evaluation of Parkinsons disease (PD) severity is essential for effective clinical management and intervention development. Despite the proposal of several gesture based PD recognition systems, including those using the finger…

计算机视觉与模式识别 · 计算机科学 2025-11-12 Abu Saleh Musa Miah , Najmul Hassan , Md Maruf Al Hossain , Yuichi Okuyama , Jungpil Shin

Parkinson's Disease (PD) affects over 10 million people worldwide, with speech impairments in up to 89% of patients. Current speech-based detection systems analyze entire utterances, potentially overlooking the diagnostic value of specific…

计算与语言 · 计算机科学 2025-10-07 Ilias Tougui , Mehdi Zakroum , Mounir Ghogho

A widely used test for the diagnosis of Parkinson's disease (PD) and Essential tremor (ET) is hand-drawn shapes,where the analysis is observationally performed by the examining neurologist. This method is subjective and is prone to bias…

计算机视觉与模式识别 · 计算机科学 2020-06-23 Nabeel Seedat , Vered Aharonson , Ilana Schlesinger

While convolutional neural networks (CNNs) have been successfully applied to many challenging classification applications, they typically require large datasets for training. When the availability of labeled data is limited, data…

计算机视觉与模式识别 · 计算机科学 2017-11-10 Terry Taewoong Um , Franz Michael Josef Pfister , Daniel Pichler , Satoshi Endo , Muriel Lang , Sandra Hirche , Urban Fietzek , Dana Kulić

Passive and non-obtrusive health monitoring using wearables can potentially bring new insights into the user's health status throughout the day and may support clinical diagnosis and treatment. However, identifying segments of free-living…

信号处理 · 电气工程与系统科学 2019-01-31 Yordan P. Raykov , Luc J. W. Evers , Reham Badawy , Marjan J. Faber , Bastiaan R. Bloem , Kasper Claes , Max A. Little

One of the symptoms of Parkinson's disease (PD) is hypomimia or reduced facial expressions. In this paper, we present a digital biomarker for PD that utilizes the study of micro-expressions. We analyzed the facial action units (AU) from…

人机交互 · 计算机科学 2021-09-06 Mohammad Rafayet Ali , Taylor Myers , Ellen Wagner , Harshil Ratnu , E. Ray Dorsey , Ehsan Hoque