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Living organisms rely on molecular networks, such as gene circuits and signaling pathways, for information processing and robust decision-making in crowded, noisy environments. Recent advances show that interacting biomolecules…

Within living cells, the transport of cargo is accomplished by groups of molecular motors. Such collective transport could utilize mechanisms which emerge from inter-motor interactions in ways that are yet to be fully understood. Here we…

生物大分子 · 定量生物学 2016-10-04 David Ando , Michelle K. Mattson , Jing Xu , Ajay Gopinathan

The dynamics of colloidal suspension confined within porous materials strongly differs from that in the bulk. In particular, within porous materials, the presence of boundaries with complex shapes entangles the longitudinal and transverse…

软凝聚态物质 · 物理学 2021-11-16 P. Malgaretti , A. M. Puertas , I. Pagonabarraga

Cells move differently on substrates with different elasticities. In particular, the persistence time of their motion is higher on stiffer substrates. We show that this behavior will result in a net transport of cells directed up a…

生物物理 · 物理学 2017-03-09 Elizaveta A. Novikova , Matthew Raab , Dennis E. Discher , Cornelis Storm

We extend the continuum theory of active nematic fluids to study cell flows and tissue dynamics inside multicellular spheroids, spherical, self-assembled aggregates of cells that are widely used as model systems to study tumour dynamics.…

软凝聚态物质 · 物理学 2022-08-18 Liam J Ruske , Julia M Yeomans

A wide range of experimental systems including gliding, swarming and swimming bacteria, in-vitro motility assays as well as shaken granular media are commonly described as self-propelled rods. Large ensembles of those entities display a…

统计力学 · 物理学 2021-01-18 Markus Bär , Robert Großmann , Sebastian Heidenreich , Fernando Peruani

A generic flow distribution network typically does not deliver its load at a uniform rate across a service area, instead oversupplying regions near the nutrient source while leaving downstream regions undersupplied. In this work we…

生物物理 · 物理学 2021-09-06 Tatyana Gavrilchenko , Eleni Katifori

Intracellular cargo transport can arise from passive diffusion, active motor-driven transport along cytoskeletal filament networks, and passive advection by fluid flows entrained by such motor/cargo motion. Active and advective transport…

生物物理 · 物理学 2012-07-24 P. Khuc Trong , J. Guck , R. E. Goldstein

Living systems are capable of locomotion, reconfiguration, and replication. To perform these tasks, cells spatiotemporally coordinate the interactions of force-generating, "active" molecules that create and manipulate non-equilibrium…

软凝聚态物质 · 物理学 2019-08-28 Tyler D. Ross , Heun Jin Lee , Zijie Qu , Rachel A. Banks , Rob Phillips , Matt Thomson

Compartmentalization into biochemically distinct organelles constantly exchanging material is one of the hallmarks of eukaryotic cells. In the most naive picture of inter-organelle transport driven by concentration gradients, concentration…

亚细胞过程 · 定量生物学 2015-05-27 Serge Dmitrieff , Pierre Sens

Escherichia coli has long been used as a model organism due to the extensive experimental characterization of its pathways and molecular components. Take chemotaxis as an example, which allows bacteria to sense and swim in response to…

细胞行为 · 定量生物学 2015-12-09 Gabriele Micali , Robert G. Endres

Fiberboids are active filaments trapped at the interface of two phases, able of harnessing energy (and matter) fluxes across the interface in order to produce a rolling-like self-propulsion. We discuss several table-top examples and develop…

软凝聚态物质 · 物理学 2020-05-19 Antony Bazir , Arthur Baumann , Falko Ziebert , Igor M. Kulic

The ability to dictate colloid motion is an important challenge in fields ranging from materials science to living systems. Here, by embedding energy landscapes in confined nematic liquid crystals, we design a versatile platform to define…

软凝聚态物质 · 物理学 2018-11-07 Yimin Luo , Daniel A. Beller , Giuseppe Boniello , Francesca Serra , Kathleen J. Stebe

Essentially all biology is active and dynamic. Biological entities autonomously sense, com- pute, and respond using energy-coupled ratchets that can produce force and do work. The cytoskeleton, along with its associated proteins and motors,…

软凝聚态物质 · 物理学 2017-03-28 Kasimira T. Stanhope , Vikrant Yadav , Christian D. Santangelo , Jennifer L. Ross

Liquid diodes are surface structures that facilitate the flow of liquids in a specific direction. When these structures are within the capillary regime, they promote liquid transport without the need for external forces. In nature, they are…

软凝聚态物质 · 物理学 2023-08-24 Camilla Sammartino , Yair Shokef , Bat-El Pinchasik

Recent studies aimed at investigating artificial analogs of bacterial colonies have shown that low-density suspensions of self-propelled particles confined in two dimensions can assemble into finite aggregates that merge and split, but have…

软凝聚态物质 · 物理学 2015-06-17 B. M. Mognetti , A. Šarić , S. Angioletti-Uberti , A. Cacciuto , C. Valeriani , D. Frenkel

Self-propelled colloidal objects, such as motile bacteria or synthetic microswimmers, have microscopically irreversible individual dynamics - a feature they share with all living systems. The incoherent behaviour of individual swimmers can…

软凝聚态物质 · 物理学 2016-04-06 J. Stenhammar , R. Wittkowski , D. Marenduzzo , M. E. Cates

Self-generated gradients have atttracted a lot of attention in the recent biological literature. It is considered as a robust strategy for a group of cells to find its way during a long journey. This note is intended to discuss various…

偏微分方程分析 · 数学 2021-09-15 Mete Demircigil , Vincent Calvez , Roxana Sublet

Single kinesin molecular motors can processively move along a microtubule (MT) a few micrometers on average before dissociating. However, cellular length scales over which transport occurs are several hundred microns and more. Why seemingly…

亚细胞过程 · 定量生物学 2019-08-21 Keshav B. Patel , Shengtan Mao , M. Gregory Forest , Samuel K. Lai , Jay M. Newby

We study the assembly of colloids in a two phase water-water system that provides an environment that can sustain bacteria, providing a new structure with rich potential to confine and structure living colloids. The water-water system,…

软凝聚态物质 · 物理学 2014-12-12 Sarah D. Hann , Mark Goulian , Daeyeon Lee , Kathleen J. Stebe
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