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The use of brain images as markers for diseases or behavioral differences is challenged by the small effects size and the ensuing lack of power, an issue that has incited researchers to rely more systematically on large cohorts. Coupled…

机器学习 · 统计学 2015-11-17 Bertrand Thirion , Andrés Hoyos-Idrobo , Jonas Kahn , Gael Varoquaux

An essential premise for neuroscience brain network analysis is the successful segmentation of the cerebral cortex into functionally homogeneous regions. Resting-state functional magnetic resonance imaging (rs-fMRI), capturing the…

神经元与认知 · 定量生物学 2023-09-20 Xiaoxiao Ma , Chunzhi Yi , Zhicai Zhong , Hui Zhou , Baichun Wei , Haiqi Zhu , Feng Jiang

Recent studies proposed the use of Total Correlation to describe functional connectivity among brain regions as a multivariate alternative to conventional pair-wise measures such as correlation or mutual information. In this work we build…

神经元与认知 · 定量生物学 2022-11-28 Qiang Li , Greg Ver Steeg , Shujian Yu , Jesus Malo

The human brain is a complex network comprised of functionally and anatomically interconnected brain regions. A growing number of studies have suggested that empirical estimates of brain networks may be useful for discovery of biomarkers of…

神经元与认知 · 定量生物学 2022-11-15 Andrew Hannum , Mario A. Lopez , Saúl A. Blanco , Richard F. Betzel

Many atlases used for brain parcellation are hierarchically organised, progressively dividing the brain into smaller sub-regions. However, state-of-the-art parcellation methods tend to ignore this structure and treat labels as if they are…

计算机视觉与模式识别 · 计算机科学 2020-09-17 Mark S. Graham , Carole H. Sudre , Thomas Varsavsky , Petru-Daniel Tudosiu , Parashkev Nachev , Sebastien Ourselin , M. Jorge Cardoso

In order to understand the complex cognitive functions of the human brain, it is essential to study the structural connectome, i.e., the wiring of different brain regions to each other through axonal pathways. However, the high degree of…

神经元与认知 · 定量生物学 2021-01-25 Anand Pathak , Shakti N. Menon , Sitabhra Sinha

The connectome, a map of the structural and/or functional connections in the brain, provides a complex representation of the neurobiological phenotypes on which it supervenes. This information-rich data modality has the potential to…

The characterisation of the brain as a "connectome", in which the connections are represented by correlational values across timeseries and as summary measures derived from graph theory analyses, has been very popular in the last years.…

机器学习 · 计算机科学 2020-03-13 Tiago Azevedo , Luca Passamonti , Pietro Liò , Nicola Toschi

The reconstruction of cerebral cortex surfaces from brain MRI scans is instrumental for the analysis of brain morphology and the detection of cortical thinning in neurodegenerative diseases like Alzheimer's disease (AD). Moreover, for a…

神经元与认知 · 定量生物学 2022-10-05 Anne-Marie Rickmann , Fabian Bongratz , Sebastian Pölsterl , Ignacio Sarasua , Christian Wachinger

Whole-brain parcellation from MRI is a critical yet challenging task due to the complexity of subdividing the brain into numerous small, irregular shaped regions. Traditionally, template-registration methods were used, but recent advances…

计算机视觉与模式识别 · 计算机科学 2026-01-15 Yucheng Li , Xiaofan Wang , Junyi Wang , Yijie Li , Xi Zhu , Mubai Du , Dian Sheng , Wei Zhang , Fan Zhang

A large number of surface-based analyses on brain imaging data adopt some specific brain atlases to better assess structural and functional changes in one or more brain regions. In these analyses, it is necessary to obtain an anatomically…

图像与视频处理 · 电气工程与系统科学 2019-10-01 Wen Zhang , Yalin Wang

The human brain is a complex system, and understanding its mechanisms has been a long-standing challenge in neuroscience. The study of the functional connectome, which maps the functional connections between different brain regions, has…

神经与进化计算 · 计算机科学 2025-04-14 Tananun Songdechakraiwut , Yutong Wu

The frequency-specific coupling mechanism of the functional human brain networks underpins its complex cognitive and behavioral functions. Nevertheless, it is not well unveiled what are the frequency-specific subdivisions and network…

神经元与认知 · 定量生物学 2021-03-30 Zhiguo Luo , Ling-Li Zeng , Hui Shen , Dewen Hu

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

神经元与认知 · 定量生物学 2011-12-23 Marcus Kaiser

Brain atlases are a ubiquitous tool used for analyzing and interpreting brain imaging datasets. Traditionally, brain atlases divided the brain into regions separated by anatomical landmarks. In the last decade, several attempts have been…

定量方法 · 定量生物学 2018-02-08 Pantea Moghimi , Kelvin O. Lim , Theoden I. Netoff

Brain networks are typically represented by adjacency matrices, where each node corresponds to a brain region. In traditional brain network analysis, nodes are assumed to be matched across individuals, but the methods used for node matching…

统计方法学 · 统计学 2025-03-21 Martin Cole , Yang Xiang , Will Consagra , Anuj Srivastava , Xing Qiu , Zhengwu Zhang

Finding the common structural brain connectivity network for a given population is an open problem, crucial for current neuro-science. Recent evidence suggests there's a tightly connected network shared between humans. Obtaining this…

神经元与认知 · 定量生物学 2017-01-10 Nahuel Lascano , Guillermo Gallardo , Rachid Deriche , Dorian Mazauric , Demian Wassermann

We tackle classification based on brain connectivity derived from diffusion magnetic resonance images. We propose a machine-learning model inspired by graph convolutional networks (GCNs), which takes a brain connectivity input graph and…

神经元与认知 · 定量生物学 2023-09-21 Anees Kazi , Jocelyn Mora , Bruce Fischl , Adrian V. Dalca , Iman Aganj

The thalamus consists of several histologically and functionally distinct nuclei increasingly implicated in brain pathology and important for treatment, motivating the need for development of fast and accurate thalamic segmentation. The…

图像与视频处理 · 电气工程与系统科学 2019-12-19 Charles Iglehart , Martin Monti , Joshua Cain , Thomas Tourdias , Manojkumar Saranathan

Cortical surface parcellation is a fundamental task in both basic neuroscience research and clinical applications, enabling more accurate mapping of brain regions. Model-based and learning-based approaches for automated parcellation…

神经元与认知 · 定量生物学 2025-12-30 Jian Li , Karthik Gopinath , Brian L. Edlow , Adrian V. Dalca , Bruce Fischl