相关论文: Observation of guided acoustic waves in a human sk…
Ultrasound waves propagating in water or soft biological tissue are strongly reflected when encountering the skull, which limits the use of ultrasound-based techniques in transcranial imaging and therapeutic applications. Current knowledge…
Transcranial ultrasound applications require accurate simulations to predict intracranial acoustic pressure fields. The current gold standard typically consists of calculating a longitudinal ultrasound wave propagation using a fluid skull…
Transcranial ultrasound is more and more used for therapy and imaging of the brain. However, the skull is a highly attenuating and aberrating medium, with different structures and acoustic properties between samples and even within a…
Transcranial low-intensity focused ultrasound can deliver energy to the brain in a minimally invasive manner for neuromodulation applications. However, continuous sonication through the skull introduces significant wave interactions,…
Within a new paradigm for communications on the nanoscale, high-frequency surface acoustic waves are becoming effective data carrier and encoder. On-chip communications require acoustic wave propagation along nano-corrugated surfaces which…
A low loss propagating electromagnetic wave is shown to exist at a gradual interface between two lossy conductive media. The electromagnetic frequency range of this phenomenon may span from UV optics to RF range. In particular, it is…
High resolution transcranial ultrasound imaging in humans has been a persistent challenge for ultrasound due to the imaging degradation effects from aberration and reverberation. These mechanisms depend strongly on skull morphology and they…
Transcranial ultrasound therapy uses focused acoustic energy to induce therapeutic bioeffects in the brain. Ultrasound must be transmitted through the skull, which is highly attenuating and heterogeneous, causing beam distortion, reducing…
Objective. While ultrasound is largely established for use in diagnostic imaging and heating therapies, its application for neuromodulation is relatively new and not well understood. The objective of the present study was to investigate…
Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human…
Imaging the human brain vasculature with high spatial and temporal resolution remains challenging in the clinic today. Transcranial ultrasound is scarcely used for cerebrovascular imaging, due to low sensitivity and strong phase aberrations…
Simulations of three dimensional ultrasound propagation in heterogeneous media are computationally intensive due to the constraints arising from the large size of the domain, which is on the order of hundreds of wavelengths, and the small…
Identifying what aspects of brain activity are responsible for conscious perception remains one of the most challenging problems in science. While progress has been made through psychophysical studies employing EEG and fMRI, research would…
Photoacoustic imaging is a promising imaging technique for human brain due to its high sensitivity and functional imaging ability. However, the skull would cause strong attenuation and distortion to the photoacoustic signals, which makes…
Acoustic impedance mismatches between soft tissues and bones are known to result in strong aberrations in optoacoustic and ultrasound images. Of particular importance are the severe distortions introduced by the human skull, impeding…
Traumatic brain injury studies on the living human brain are experimentally infeasible. We present a simulation approach that models ultrasound propagation in the human brain while it is moving due to the complex shear shock wave…
Background: Trans-spinal FUS (tsFUS) has recently been shown promise in modulating spinal reflexes in rodents, opening new avenues for spinal cord interventions in motor control and pain management. However, anatomical differences between…
The internal deformation of the brain is far more complex than the rigid motion of the skull. An ultrasound imaging technique that we have developed has a combination of penetration, frame-rate, and motion detection accuracy required to…
Transcranial focused ultrasound (tFUS) is an emerging modality for non-invasive brain stimulation and therapeutic intervention, offering millimeter-scale spatial precision and the ability to target deep brain structures. However, the…
Hemodynamic changes occur in stroke and neurodegenerative diseases. Developing imaging techniques allowing the in vivo visualization and quantification of cerebral blood flow would help better understand the underlying mechanism of those…