相关论文: DeepIso: A Deep Learning Model for Peptide Feature…

In evidence-based medicine (EBM), defining a clinical question in terms of the specific patient problem aids the physicians to efficiently identify appropriate resources and search for the best available evidence for medical treatment. In…

Motivation: Drug discovery demands rapid quantification of compound-protein interaction (CPI). However, there is a lack of methods that can predict compound-protein affinity from sequences alone with high applicability, accuracy, and…

Peptides play a pivotal role in a wide range of biological activities through participating in up to 40% protein-protein interactions in cellular processes. They also demonstrate remarkable specificity and efficacy, making them promising…

Drug discovery projects entail cycles of design, synthesis, and testing that yield a series of chemically related small molecules whose properties, such as binding affinity to a given target protein, are progressively tailored to a…

Deep learning (DL) has gained popularity in recent years as an effective tool for classifying the current health and predicting the future of industrial equipment. However, most DL models have black-box components with an underlying…

In recent years, there has been a notable advancement in the integration of healthcare and technology, particularly evident in the field of medical image analysis. This paper introduces a pioneering approach in dermatology, presenting a…

The identification and property prediction of chemical molecules is of central importance in the advancement of drug discovery and material science, where the tandem mass spectrometry technology gives valuable fragmentation cues in the form…

We propose a method for integration of features extracted using deep representations of Convolutional Neural Networks (CNNs) each of which is learned using a different image dataset of objects and materials for material recognition. Given a…

In response to the global COVID-19 pandemic, there has been a critical demand for protective measures, with face masks emerging as a primary safeguard. The approach involves a two-fold strategy: first, recognizing the presence of a face by…

MOTIVATION: Proteins fold into complex structures that are crucial for their biological functions. Experimental determination of protein structures is costly and therefore limited to a small fraction of all known proteins. Hence, different…

De novo peptide sequencing is a critical task in proteomics. However, the performance of current deep learning-based methods is limited by the inherent complexity of mass spectrometry data and the heterogeneous distribution of noise…

Unbiased, label-free proteomics is becoming a powerful technique for measuring protein expression in almost any biological sample. The output of these measurements after preprocessing is a collection of features and their associated…

De novo peptide sequencing algorithms have been widely used in proteomics to analyse tandem mass spectra (MS/MS) and assign them to peptides, but quality-control methods to evaluate the confidence of de novo peptide sequencing are lagging…

Deep learning (DL) techniques have had unprecedented success when applied to images, waveforms, and texts to cite a few. In general, when the sample size (N) is much greater than the number of features (d), DL outperforms previous machine…

In this paper, we studied extensively on different deep learning based methods to detect melanoma and skin lesion cancers. Melanoma, a form of malignant skin cancer is very threatening to health. Proper diagnosis of melanoma at an earlier…

The availability of large annotated datasets and affordable computation power have led to impressive improvements in the performance of CNNs on various object detection and recognition benchmarks. These, along with a better understanding of…

Understanding protein solubility is essential for their functional applications. Computational methods for predicting protein solubility are crucial for reducing experimental costs and enhancing the efficiency and success rates of protein…

The computational prediction of a protein structure from its sequence generally relies on a method to assess the quality of protein models. Most assessment methods rank candidate models using heavily engineered structural features, defined…

While state-of-the-art models for breast cancer detection leverage multi-view mammograms for enhanced diagnostic accuracy, they often focus solely on visual mammography data. However, radiologists document valuable lesion descriptors that…

Structure based ligand discovery is one of the most successful approaches for augmenting the drug discovery process. Currently, there is a notable shift towards machine learning (ML) methodologies to aid such procedures. Deep learning has…