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In the context of a binary treatment, matching is a well-established approach in causal inference. However, in the context of a continuous treatment or exposure, matching is still underdeveloped. We propose an innovative matching approach…

Numerous studies have examined the associations between long-term exposure to fine particulate matter (PM2.5) and adverse health outcomes. Recently, many of these studies have begun to employ high-resolution predicted PM2.5 concentrations,…

统计方法学 · 统计学 2022-11-29 Kevin P. Josey , Priyanka deSouza , Xiao Wu , Danielle Braun , Rachel Nethery

Quantifying the causal effects of continuous exposures on outcomes of interest is critical for social, economic, health, and medical research. However, most existing software packages focus on binary exposures. We develop the CausalGPS R…

统计计算 · 统计学 2023-10-03 Naeem Khoshnevis , Xiao Wu , Danielle Braun

Propensity score (PS) matching to estimate causal effects of exposure is biased when unmeasured spatial confounding exists. Some exposures are continuous yet dependent on a binary variable (e.g., level of a contaminant (continuous) within a…

统计方法学 · 统计学 2026-05-04 Honghyok Kim , Michelle Bell

The opportunity to assess short term impact of air pollution relies on the causal interpretation of the exposure-outcome association, but up to now few studies explicitly faced this issue within a causal inference framework. In this paper,…

When exposure measurement error (EME), confounder measurement error (CME), or both are present, health effect estimates regarding exposure mixtures and critical exposure time-window may not represent the true effects. For example, in air…

统计理论 · 数学 2025-05-28 Honghyok Kim

Exposure to fine particulate matter ($PM_{2.5}$) poses significant health risks and accurately determining the shape of the relationship between $PM_{2.5}$ and health outcomes has crucial policy ramifications. While various statistical…

应用统计 · 统计学 2023-06-06 Michael Cork , Daniel Mork , Francesca Dominici

Studies have shown that exposure to air pollution, even at low levels, significantly increases mortality. As regulatory actions are becoming prohibitively expensive, robust evidence to guide the development of targeted interventions to…

应用统计 · 统计学 2018-02-20 Kwonsang Lee , Dylan S. Small , Francesca Dominici

The generalized propensity score (GPS) is an extension of the propensity score for use with quantitative or continuous exposures (e.g., dose of medication or years of education). Current GPS methods allow estimation of the dose-response…

统计方法学 · 统计学 2020-09-01 Justin R. Williams , Catherine M. Crespi

One way to quantify exposure to air pollution and its constituents in epidemiologic studies is to use an individual's nearest monitor. This strategy results in potential inaccuracy in the actual personal exposure, introducing bias in…

Unmeasured confounding is a key challenge for causal inference. In this paper, we establish a framework for unmeasured confounding adjustment with negative control variables. A negative control outcome is associated with the confounder but…

统计方法学 · 统计学 2024-09-09 Wang Miao , Xu Shi , Yilin Li , Eric Tchetgen Tchetgen

This paper presents an approach to estimating the health effects of an environmental hazard. The approach is general in nature, but is applied here to the case of air pollution. It uses a computer model involving ambient pollution and…

应用统计 · 统计学 2007-11-01 Gavin Shaddick , Duncan Lee , James V. Zidek , Ruth Salway

The association between multidimensional exposure patterns and outcomes is commonly investigated by first applying cluster analysis algorithms to derive patterns and then estimating the associations. However, errors in the underlying…

统计方法学 · 统计学 2023-05-31 Timm Intemann , Iris Pigeot

In this paper, we undertake a case study to estimate a causal exposure-response function (ERF) for long-term exposure to fine particulate matter (PM$_{2.5}$) and respiratory hospitalizations in socioeconomically disadvantaged children using…

统计方法学 · 统计学 2024-07-15 Jenny J. Lee , Xiao Wu , Francesca Dominici , Rachel C. Nethery

Motivated by environmental policy questions, we address the challenges of estimation, change point detection, and uncertainty quantification of a causal exposure-response function (CERF). Under a potential outcome framework, the CERF…

统计方法学 · 统计学 2023-01-27 Boyu Ren , Xiao Wu , Danielle Braun , Natesh Pillai , Francesca Dominici

The Clean Air Act mandates that the National Ambient Air Quality Standards (NAAQS) must be routinely assessed to protect populations based on the latest science. Therefore, researchers should continue to address whether exposure to levels…

统计方法学 · 统计学 2020-01-09 Georgia Papadogeorgou , Francesca Dominici

Environmental epidemiologists are often interested in estimating the effect of time-varying functions of the exposure history on health outcomes. However, the individual exposure measurements that constitute the history upon which an…

统计方法学 · 统计学 2025-05-23 Ce Yang , Ning Zhang , Jiaxuan Li , Unnati V. Mehta , Jaime E. Hart , Donna Spiegelman , Molin Wang

We develop new matching estimators for estimating causal quantile exposure-response functions and quantile exposure effects with continuous treatments. We provide identification results for the parameters of interest and establish the…

统计方法学 · 统计学 2023-08-04 Luca Merlo , Francesca Dominici , Lea Petrella , Nicola Salvati , Xiao Wu

In epidemiological studies of air pollution and public health, estimating the health impact of exposure to air pollution may be hindered by the unknown functional form of the exposure-outcome association and by unmeasured confounding…

统计方法学 · 统计学 2026-01-28 Carlo Zaccardi , Pasquale Valentini , Luigi Ippoliti , Alexandra M. Schmidt

The proximal causal inference framework enables the identification and estimation of causal effects in the presence of unmeasured confounding by leveraging two disjoint sets of observed strong proxies: negative control treatments and…

统计方法学 · 统计学 2025-12-16 Antonio Olivas-Martinez , Peter B. Gilbert , Andrea Rotnitzky
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