相关论文: Detection Limit for Optically Sensing Specific Pro…
Specific binding of proteins to DNA is one of the most common ways in which gene expression is controlled. Although general rules for the DNA-protein recognition can be derived, the ambiguous and complex nature of this mechanism precludes a…
Understanding protein motion within the cell is crucial for predicting reaction rates and macromolecular transport in the cytoplasm. A key question is how crowded environments affect protein dynamics through hydrodynamic and direct…
Bacterial sensor systems can be used for the detection and measurement of molecular signal concentrations. The dynamics of the sensor directly depend on the biological properties of the bacterial sensor cells; manipulation of these features…
Laser photocoagulation is one of the most frequently used treatment approaches for retinal diseases such as diabetic retinopathy and macular edema. The use of model-based control, such as Model Predictive Control (MPC), enhances a safe and…
High resolution imaging is achieved using increasingly larger apertures and successively shorter wavelengths. Optical aperture synthesis is an important high-resolution imaging technology used in astronomy. Conventional long baseline…
We consider a differential model describing neuro-physiological contrast perception phenomena induced by surrounding orientations. The mathematical formulation relies on a cortical-inspired modelling [10] largely used over the last years to…
We propose a novel approach to detect the binding between proteins making use of the anomalous diffraction of natively present heavy elements inside the molecule 3D structure. In particular, we suggest considering sulfur atoms contained in…
Diffusion of proteins on length scales of their own diameter in highly concentrated solutions is essential for understanding the cellular machinery of living cells, but its experimental characterization remains a challenge. While X-ray…
An approach to the mechanical behaviour of textile composites at the scale of their constituting fibres, using an implicit finite element simulation code, is proposed in this chapter. The approach is based on efficient methods and…
Temporally and spatially resolved measurements of protein transport inside cells provide important clues to the functional architecture and dynamics of biological systems. Fluorescence Recovery After Photobleaching (FRAP) technique has been…
The interaction of proteins with small molecules is fundamental to their function in living organisms and it is widely studied in drug development. Here we compare optical trapping dynamics of streptavidin and biotinylated streptavidin…
Single molecule fluorescence tracking provides information at nm-scale and ms-temporal resolution about the dynamics and interaction of individual molecules in a biological environment. While the dynamic behavior of isolated molecules can…
We propose a unique framework to study the topological properties of an optical bound state in the continuum(BIC). We employ the interactions between proximity resonances undergoing avoided resonance crossing in a specialty optical…
Identifying protein-protein interactions is crucial for a systems-level understanding of the cell. Recently, algorithms based on inverse statistical physics, e.g. Direct Coupling Analysis (DCA), have allowed to use evolutionarily related…
We derive analytic expressions for the sensitivity and figure of merit for refractive index sensing with plasmonic resonators in the quasistatic limit. Based on these expressions the limits of detection and their origins are investigated.…
When subjected to monochromatic incident light a nanoparticle will emit light which then interferes with the incident beam. With sufficient contrast and sufficiently close to the particle this interference pattern may be recorded with a…
Computational protein-protein interaction (PPI) prediction techniques can contribute greatly in reducing time, cost and false-positive interactions compared to experimental approaches. Sequence is one of the key and primary information of…
Dynamic reciprocity imposes stringent performance constraints on nonlinear optical devices such as isolators and circulators. The seminal result by Shi et al. establishes that nonlinear optical devices relying on the intensity-dependent…
We study the formation of protein-protein encounter complexes with a Langevin equation approach that considers direct, steric and thermal forces. As three model systems with distinctly different properties we consider the pairs…
The prediction of protein-ligand binding affinity is of great significance for discovering lead compounds in drug research. Facing this challenging task, most existing prediction methods rely on the topological and/or spatial structure of…