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Brain network topology, derived from functional magnetic resonance imaging (fMRI), holds promise for improving Alzheimer's disease (AD) diagnosis. Current methods primarily focus on lower-order topological features, often overlooking the…

几何拓扑 · 数学 2025-09-19 Dengyi Zhao , Shanyong Li , Yunping Wang , Chenfei Wang , Zhiheng Zhou , Guiying Yan , Xingqin Qi

We introduce TempoCave, a novel visualization application for analyzing dynamic brain networks, or connectomes. TempoCave provides a range of functionality to explore metrics related to the activity patterns and modular affiliations of…

人机交互 · 计算机科学 2020-01-16 Ran Xu , Manu Mathew Thomas , Alex Leow , Olusola Ajilore , Angus G. Forbes

Neurodegeneration as measured through magnetic resonance imaging (MRI) is recognized as a potential biomarker for diagnosing Alzheimer's disease (AD), but is generally considered less specific than amyloid or tau based biomarkers. Due to a…

计算机视觉与模式识别 · 计算机科学 2024-08-06 Rosemary He , Gabriella Ang , Daniel Tward

Representation of brain network interactions is fundamental to the translation of neural structure to brain function. As such, methodologies for mapping neural interactions into structural models, i.e., inference of functional connectome…

神经元与认知 · 定量生物学 2022-03-18 Rahul Biswas , Eli Shlizerman

The study of random networks in a neuroscientific context has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the…

神经元与认知 · 定量生物学 2017-07-11 Daniel Fraiman , Ricardo Fraiman

This article proposes a Bayesian approach to regression with a continuous scalar response and an undirected network predictor. Undirected network predictors are often expressed in terms of symmetric adjacency matrices, with rows and columns…

统计方法学 · 统计学 2018-03-29 Sharmistha Guha , Abel Rodriguez

Brain networks from functional MRI have advanced our understanding of cortical activity and its disruption in neurodegenerative disorders. Recent work has increasingly focused on dynamic (time-varying) brain networks that capture both…

神经元与认知 · 定量生物学 2026-04-14 Nicolas Rubido , Venia Batziou , Marwan Fuad , Vesna Vuksanovic

Graph neural network (GNN) models are increasingly being used for the classification of electroencephalography (EEG) data. However, GNN-based diagnosis of neurological disorders, such as Alzheimer's disease (AD), remains a relatively…

神经元与认知 · 定量生物学 2023-12-21 Dominik Klepl , Fei He , Min Wu , Daniel J. Blackburn , Ptolemaios G. Sarrigiannis

The imaging community has increasingly adopted machine learning (ML) methods to provide individualized imaging signatures related to disease diagnosis, prognosis, and response to treatment. Clinical neuroscience and cancer imaging have been…

Alzheimer's disease is the most common cause of dementia, yet hard to diagnose precisely without invasive techniques, particularly at the onset of the disease. This work approaches image analysis and classification of synthetic…

图像与视频处理 · 电气工程与系统科学 2017-12-05 Wellington Pinheiro dos Santos , Ricardo Emmanuel de Souza , Plínio B. dos Santos Filho

Early detection is a crucial goal in the study of Alzheimer's Disease (AD). In this work, we describe several techniques to boost the performance of 3D deep convolutional neural networks (CNNs) trained to detect AD using structural brain…

图像与视频处理 · 电气工程与系统科学 2020-04-07 Sheng Liu , Chhavi Yadav , Carlos Fernandez-Granda , Narges Razavian

Alzheimer's disease (AD) is a neurodegenerative disorder marked by memory loss and cognitive decline, making early detection vital for timely intervention. However, early diagnosis is challenging due to the heterogeneous presentation of…

神经元与认知 · 定量生物学 2025-09-24 Ali Khazaee , Abdolreza Mohammadi , Ruairi O'Reilly

Early diagnosis and discovery of therapeutic drug targets are crucial objectives for effective management of Alzheimer's Disease (AD). Current approaches for AD diagnosis and treatment planning are based on radiological imaging and largely…

机器学习 · 计算机科学 2026-05-01 Maryam Khalid , Fadeel Sher Khan , John Broussard , Arko Barman

This work considers a continuous framework to characterize the population-level variability of structural connectivity. Our framework assumes the observed white matter fiber tract endpoints are driven by a latent random function defined…

统计计算 · 统计学 2022-07-19 William Consagra , Martin Cole , Zhengwu Zhang

Brain structural networks are often represented as discrete adjacency matrices with elements summarizing the connectivity between pairs of regions of interest (ROIs). These ROIs are typically determined a-priori using a brain atlas. The…

统计计算 · 统计学 2023-08-11 William Consagra , Martin Cole , Xing Qiu , Zhengwu Zhang

Data harmonization is the process by which an equivalence is developed between two variables measuring a common trait. Our problem is motivated by dementia research in which multiple tests are used in practice to measure the same underlying…

统计方法学 · 统计学 2021-10-13 Steven Wilkins-Reeves , Yen-Chi Chen , Kwun Chuen Gary Chan

Sickle cell anemia, which is characterized by abnormal erythrocyte morphology, can be detected using microscopic images. Computational techniques in medicine enhance the diagnosis and treatment efficiency. However, many computational…

计算机视觉与模式识别 · 计算机科学 2024-12-25 Victor Júnio Alcântara Cardoso , Rodrigo Moreira , João Fernando Mari , Larissa Ferreira Rodrigues Moreira

Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided…

图像与视频处理 · 电气工程与系统科学 2021-07-29 Fan Zhang , Bo Pan , Pengfei Shao , Peng Liu , Shuwei Shen , Peng Yao , Ronald X. Xu

Identification of brain regions related to the specific neurological disorders are of great importance for biomarker and diagnostic studies. In this paper, we propose an interpretable Graph Convolutional Network (GCN) framework for the…

机器学习 · 计算机科学 2022-04-29 Houliang Zhou , Lifang He , Yu Zhang , Li Shen , Brian Chen

An important goal of medical imaging is to be able to precisely detect patterns of disease specific to individual scans; however, this is challenged in brain imaging by the degree of heterogeneity of shape and appearance. Traditional…

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