相关论文: HERITAGE: a Monte Carlo code to evaluate the viabi…
The survival of a genetically healthy multi-generational crew is of a prime concern when dealing with space travel. It has been shown that determining a realistic population size is tricky as many parameters (such as infertility,…
We updated the agent based Monte Carlo code HERITAGE that simulates human evolution within restrictive environments such as interstellar, sub-light speed spacecraft in order to include the effects of population genetics. We incorporated a…
In the first papers of our series on interstellar generation ships we have demonstrated that the numerical code HERITAGE is able to calculate the success rate of multi-generational space missions. Thanks to the social and breeding…
In the first paper of this series, we included the effects of population genetics in the agent-based Monte Carlo code HERITAGE under the hypothesis of neutral phenotypic effects. It implied that mutations (genetic changes) had only neutral…
Generative models derived from large protein sequence alignments define complex fitness landscapes, but their utility for accurately modeling non-equilibrium evolutionary dynamics remains unclear. In this work, we perform a rigorous…
Biological genomes are divided into coding and non-coding regions. Introns are non-coding parts within genes, while the remaining non-coding parts are intergenic sequences. To study the evolutionary significance of recombination inside…
Intragenomic recombination (crossover) is a very important evolutionary mechanism. The crossover events are not evenly distributed along the natural chromosomes. Monte Carlo simulations revealed that frequency of recombinations decides…
Population Monte Carlo simulations in the form commonly referred to as population annealing can serve as a useful meta-algorithm for simulating systems with complex free-energy landscapes. In the present paper we provide an easily…
Monte Carlo methods to evaluate and maximize the likelihood function enable the construction of confidence intervals and hypothesis tests, facilitating scientific investigation using models for which the likelihood function is intractable.…
Using a lattice model based on Monte Carlo simulations, we study the role of the reproduction pattern on the fate of an evolving population. Each individual is under the selection pressure from the environment and random mutations. The…
We present a population control method with sampling and regulation steps for Monte Carlo particles involved in the numerical simulation of a transport equation. We recall in the first section the difficulties related to the variance…
Following genetic ancestry in eukaryote populations poses several open problems due to sexual reproduction and recombination. The history of extant genetic material is usually modeled backwards in time, but tracking chromosomes at a large…
Generative foundation models trained on tokenized electronic health record (EHR) timelines show promise for clinical outcome prediction via Monte Carlo sampling of simulated future trajectories. However, this approach suffers from three…
We describe the simulation method of modelling the population evolution using Monte Carlo based on the Penna model. Individuals in the populations are represented by their diploid genomes. Genes expressed after the minimum reproduction age…
Background: Hybridogenesis is a very interesting example of reproduction which seems to integrate the sexual and clonal processes in one system. In a case of frogs, described in the paper, two parental species - Rana lessonae and Rana…
Mass changes due to strong stellar winds and binary mass transfer have a dramatic impact on the consequent evolution of stars. This is generally not accounted for in population synthesis codes which are built using single star evolution…
In recent years, observations have shown that multiple-star systems such as hierarchical triple and quadruple-star systems are common, especially among massive stars. They are potential sources of interesting astrophysical phenomena such as…
The drift-barrier hypothesis states that random genetic drift constrains the refinement of a phenotype under natural selection. The influence of effective population size and the genome-wide deleterious mutation rate were studied…
The provision of intergenerational care, via the Grandmother Hypothesis, has been implicated in the evolution of post-fertile longevity, particularly in humans. However, if grandmothering does provide fitness benefits, a key question is why…
The vast majority of the orbital population today is unobservable and untracked because of their small size. These lethal non-trackable objects will only become more numerous as more payloads and debris are launched into orbit and increase…