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Deducing the structure of neural circuits is one of the central problems of modern neuroscience. Recently-introduced calcium fluorescent imaging methods permit experimentalists to observe network activity in large populations of neurons,…

应用统计 · 统计学 2011-07-22 Yuriy Mishchencko , Joshua T. Vogelstein , Liam Paninski

Studying neural connectivity is considered one of the most promising and challenging areas of modern neuroscience. The underpinnings of cognition are hidden in the way neurons interact with each other. However, our experimental methods of…

机器学习 · 统计学 2018-06-22 George Panagopoulos

Inferring a binary connectivity graph from resting-state fMRI data for a single subject requires making several methodological choices and assumptions that can significantly affect the results. In this study, we investigate the robustness…

统计方法学 · 统计学 2025-03-20 Alice Chevaux , Ali Fahkar , Kévin Polisano , Irène Gannaz , Sophie Achard

Networks - collections of interacting elements or nodes - abound in the natural and manmade worlds. For many networks, complex spatiotemporal dynamics stem from patterns of physical interactions unknown to us. To infer these interactions,…

定量方法 · 定量生物学 2015-05-13 Mark A. Kramer , Uri T. Eden , Sydney S. Cash , Eric D. Kolaczyk

Neuroscience has recently made much progress, expanding the complexity of both neural-activity measurements and brain-computational models. However, we lack robust methods for connecting theory and experiment by evaluating our new big…

定量方法 · 定量生物学 2023-07-06 Heiko H. Schütt , Alexander D. Kipnis , Jörn Diedrichsen , Nikolaus Kriegeskorte

This article presents a mini-review about the progress in inferring monosynaptic connections from spike trains of multiple neurons over the past twenty years. First, we explain a variety of meanings of ``neuronal connectivity'' in different…

神经元与认知 · 定量生物学 2024-03-19 Ryota Kobayashi , Shigeru Shinomoto

Sustainable research on computational models of neuronal networks requires published models to be understandable, reproducible, and extendable. Missing details or ambiguities about mathematical concepts and assumptions, algorithmic…

The study of networks has witnessed an explosive growth over the past decades with several ground-breaking methods introduced. A particularly interesting -- and prevalent in several fields of study -- problem is that of inferring a function…

Knowing brain connectivity is of great importance both in basic research and for clinical applications. We are proposing a method to infer directed connectivity from zero-lag covariances of neuronal activity recorded at multiple sites. This…

Data produced by resting-state functional Magnetic Resonance Imaging are widely used to infer brain functional connectivity networks. Such networks correlate neural signals to connect brain regions, which consist in groups of dependent…

统计方法学 · 统计学 2023-12-05 Hanâ Lbath , Alexander Petersen , Sophie Achard

We consider the problem of inferring the functional connectivity of a large-scale computer network from sparse time series of events emitted by its nodes. We do so under the following three domain-specific constraints: (a) non-stationarity…

机器学习 · 计算机科学 2018-02-13 Antoine Messager , George Parisis , Istvan Z Kiss , Robert Harper , Phil Tee , Luc Berthouze

Identifying stimulus-driven neural activity patterns is critical for studying the neural basis of cognition. This can be particularly challenging in intracranial datasets, where electrode locations typically vary across patients. This…

神经元与认知 · 定量生物学 2022-02-07 Jeremy R. Manning

Descriptive and inferential social network analysis has become common in public administration studies of network governance and management. A large literature has developed in two broad categories: antecedents of network structure, and…

社会与信息网络 · 计算机科学 2024-09-02 Travis A. Whetsell , Michael D. Siciliano

Network structures underlie the dynamics of many complex phenomena, from gene regulation and foodwebs to power grids and social media. Yet, as they often cannot be observed directly, their connectivities must be inferred from observations…

机器学习 · 计算机科学 2023-11-02 Thomas Gaskin , Grigorios A. Pavliotis , Mark Girolami

Sequential neuronal activity underlies a wide range of processes in the brain. Neuroscientific evidence for neuronal sequences has been reported in domains as diverse as perception, motor control, speech, spatial navigation and memory.…

适应与自组织系统 · 物理学 2020-04-03 Sascha Frölich , Dimitrije Marković , Stefan J. Kiebel

We introduce and study methods for inferring and learning from correspondences among neurons. The approach enables alignment of data from distinct multiunit studies of nervous systems. We show that the methods for inferring correspondences…

神经元与认知 · 定量生物学 2015-01-28 Ashish Kapoor , E. Paxon Frady , Stefanie Jegelka , William B. Kristan , Eric Horvitz

Network inference, the task of reconstructing interactions in a complex system from experimental observables, is a central yet extremely challenging problem in systems biology. While much progress has been made in the last two decades,…

定量方法 · 定量生物学 2024-09-12 Stephen Y Zhang

Transcriptomic data is a treasure-trove in modern molecular biology, as it offers a comprehensive viewpoint into the intricate nuances of gene expression dynamics underlying biological systems. This genetic information must be utilised to…

分子网络 · 定量生物学 2023-12-13 Vikram Singh , Vikram Singh

The idea to estimate the statistical interdependence among (interacting) brain regions has motivated numerous researchers to investigate how the resulting connectivity patterns and networks may organize themselves under any conceivable…

神经元与认知 · 定量生物学 2021-02-03 Matteo Fraschini , Simone Maurizio La Cava , Luca Didaci , Luigi Barberini

Networks represent relationships between entities in many complex systems, spanning from online social interactions to biological cell development and brain connectivity. In many cases, relationships between entities are unambiguously…

社会与信息网络 · 计算机科学 2018-01-23 Ivan Brugere , Brian Gallagher , Tanya Y. Berger-Wolf
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