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Protein function does not solely depend on structure but often relies on dynamical transitions between distinct conformations. Despite this fact, our ability to characterize or predict protein dynamics is substantially less developed…

统计力学 · 物理学 2026-05-08 Michael A. Sauer , Souvik Mondal , Brandon Neff , Sthitadhi Maiti , Matthias Heyden

Explicit functional forms for the generator derivatives of well-known one-parameter Archimedean copulas are derived. These derivatives are essential for likelihood inference as they appear in the copula density, conditional distribution…

统计理论 · 数学 2013-09-19 Marius Hofert , Martin Mächler , Alexander J. McNeil

Principal component analysis continues to be a powerful tool in dimension reduction of high dimensional data. We assume a variance-diverging model and use the high-dimension, low-sample-size asymptotics to show that even though the…

统计理论 · 数学 2020-09-28 Sungkyu Jung

For testing the independence of two vectors with respective dimensions $p_1$ and $p_2$, the existing literature in high-dimensional statistics all assume that both dimensions $p_1$ and $p_2$ grow to infinity with the sample size. However,…

统计方法学 · 统计学 2018-01-23 Weiming Li , Jiaqi Chen , Jianfeng Yao

Sequential multi-class diagnosis, also known as multi-hypothesis testing, is a classical sequential decision problem with broad applications. However, the optimal solution remains, in general, unknown as the dynamic program suffers from the…

信息论 · 计算机科学 2020-12-07 Jue Wang

Modern biotechnologies often result in high-dimensional data sets with much more variables than observations (n $\ll$ p). These data sets pose new challenges to statistical analysis: Variable selection becomes one of the most important…

机器学习 · 统计学 2014-11-06 Benjamin Hofner , Luigi Boccuto , Markus Göker

Selectivity estimation aims at estimating the number of database objects that satisfy a selection criterion. Answering this problem accurately and efficiently is essential to many applications, such as density estimation, outlier detection,…

数据库 · 计算机科学 2021-05-28 Yaoshu Wang , Chuan Xiao , Jianbin Qin , Rui Mao , Onizuka Makoto , Wei Wang , Rui Zhang , Yoshiharu Ishikawa

We consider high-dimensional binary classification by sparse logistic regression. We propose a model/feature selection procedure based on penalized maximum likelihood with a complexity penalty on the model size and derive the non-asymptotic…

统计理论 · 数学 2018-11-20 Felix Abramovich , Vadim Grinshtein

We present a simple method for assessing the predictive performance of high-dimensional models directly in data space when only samples are available. Our approach is to compare the quantiles of observables predicted by a model to those of…

天体物理仪器与方法 · 物理学 2025-01-16 Stephen Thorp , Hiranya V. Peiris , Daniel J. Mortlock , Justin Alsing , Boris Leistedt , Sinan Deger

We propose a method for variable selection and basis learning for high-dimensional classification with ordinal responses. The proposed method extends sparse multiclass linear discriminant analysis, with the aim of identifying not only the…

统计方法学 · 统计学 2025-02-17 Minwoo Kim , Sangil Han , Jeongyoun Ahn , Sungkyu Jung

We propose new statistical tests, in high-dimensional settings, for testing the independence of two random vectors and their conditional independence given a third random vector. The key idea is simple, i.e., we first transform each…

统计方法学 · 统计学 2026-01-28 Jinyuan Chang , Yue Du , Jing He , Qiwei Yao

The standard paired-sample testing approach in the multidimensional setting applies multiple univariate tests on the individual features, followed by p-value adjustments. Such an approach suffers when the data carry numerous features. A…

机器学习 · 统计学 2023-09-29 Ioannis Bargiotas , Argyris Kalogeratos , Nicolas Vayatis

For a set of dependent random variables, without stationary or the strong mixing assumptions, we derive the asymptotic independence between their sums and maxima. Then we apply this result to high-dimensional testing problems, where we…

统计方法学 · 统计学 2022-05-12 Long Feng , Tiefeng Jiang , Xiaoyun Li , Binghui Liu

Thanks to its favorable properties, the multivariate normal distribution is still largely employed for modeling phenomena in various scientific fields. However, when the number of components $p$ is of the same asymptotic order as the sample…

统计理论 · 数学 2022-11-17 Caizhu Huang , Claudia Di Caterina , Nicola Sartori

We are interested in testing general linear hypotheses in a high-dimensional multivariate linear regression model. The framework includes many well-studied problems such as two-sample tests for equality of population means, MANOVA and…

统计方法学 · 统计学 2018-10-05 Haoran Li , Alexander Aue , Debashis Paul

In this paper, we investigate the impact of high-dimensional Principal Component (PC) adjustments on inferring the effects of variables on outcomes, with a focus on applications in genetic association studies where PC adjustment is commonly…

统计理论 · 数学 2025-06-30 Sohom Bhattacharya , Rounak Dey , Rajarshi Mukherjee

This paper introduces the \textit{weighted partial copula} function for testing conditional independence. The proposed test procedure results from these two ingredients: (i) the test statistic is an explicit Cramer-von Mises transformation…

统计方法学 · 统计学 2021-02-15 Pascal Bianchi , Kevin Elgui , François Portier

Missing data present challenges in data analysis. Naive analyses such as complete-case and available-case analysis may introduce bias and loss of efficiency, and produce unreliable results. Multiple imputation (MI) is one of the most widely…

统计方法学 · 统计学 2019-05-15 Domonique W. Hodge , Sandra E. Safo , Qi Long

The present paper answers the following questions related with high-dimensional manova: (i) is it possible to develop a likelihood ratio test for high-dimensional manova? (ii) would such test perform well? (iii) would it be able to…

统计方法学 · 统计学 2025-07-03 Carlos A. Coelho

Diffusion models have shown remarkable empirical success in sampling from rich multi-modal distributions. Their inference relies on numerically solving a certain differential equation. This differential equation cannot be solved in closed…

机器学习 · 计算机科学 2026-01-16 Khashayar Gatmiry , Sitan Chen , Adil Salim