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Over the past two decades, considerable strides have been made in advancing neuroscientific techniques, yet challenges remain in attributing causality to observed associations. This review addresses a fundamental issue in observational…

其他定量生物学 · 定量生物学 2025-11-04 Eric W. Bridgeford , Brian S. Caffo , Maya B. Mathur , Russell A. Poldrack

This paper discusses the fundamental principles of causal inference - the area of statistics that estimates the effect of specific occurrences, treatments, interventions, and exposures on a given outcome from experimental and observational…

统计方法学 · 统计学 2021-12-03 Francesca Dominici , Falco J. Bargagli-Stoffi , Fabrizia Mealli

Causal decomposition analyses can help build the evidence base for interventions that address health disparities (inequities). They ask how disparities in outcomes may change under hypothetical intervention. Through study design and…

统计方法学 · 统计学 2020-09-17 John W. Jackson

Causal inference in connected populations is non-trivial, because the treatment assignments of units can affect the outcomes of other units via treatment and outcome spillover. Since outcome spillover induces dependence among outcomes,…

统计方法学 · 统计学 2025-12-25 Subhankar Bhadra , Michael Schweinberger

The propensity score is a common tool for estimating the causal effect of a binary treatment in observational data. In this setting, matching, subclassification, imputation, or inverse probability weighting on the propensity score can…

统计方法学 · 统计学 2018-01-03 Michael J Lopez , Roee Gutman

Return-to-baseline is an important method to impute missing values or unobserved potential outcomes when certain hypothetical strategies are used to handle intercurrent events in clinical trials. Current return-to-baseline approaches seen…

统计方法学 · 统计学 2021-11-19 Yongming Qu , Biyue Dai

Causal evidence is needed to act and it is often enough for the evidence to point towards a direction of the effect of an action. For example, policymakers might be interested in estimating the effect of slightly increasing taxes on private…

统计方法学 · 统计学 2020-08-11 Dominik Rothenhäusler , Bin Yu

The aim of this paper is to discuss a recent result which shows that probabilistic inference in the presence of (unknown) causal mechanisms can be tractable for models that have traditionally been viewed as intractable. This result was…

人工智能 · 计算机科学 2022-02-08 Adnan Darwiche

Unobserved confounding is one of the main challenges when estimating causal effects. We propose a causal reduction method that, given a causal model, replaces an arbitrary number of possibly high-dimensional latent confounders with a single…

机器学习 · 统计学 2023-02-24 Maximilian Ilse , Patrick Forré , Max Welling , Joris M. Mooij

The ICH E9 addendum introduces the term intercurrent event to refer to events that happen after randomisation and that can either preclude observation of the outcome of interest or affect its interpretation. It proposes five strategies for…

统计方法学 · 统计学 2021-07-12 Camila Olarte Parra , Rhian M. Daniel , Jonathan W. Bartlett

This paper proposes a framework that incorporates the two-way fixed effects model as a special case to conduct causal inference with a continuous treatment. Treatments are allowed to change over time and potential outcomes are dependent on…

统计方法学 · 统计学 2025-07-01 Zhiguo Xiao , Peikai Wu

Matching in causal inference from observational data aims to construct treatment and control groups with similar distributions of covariates, thereby reducing confounding and ensuring an unbiased estimation of treatment effects. This…

人工智能 · 计算机科学 2025-04-15 Sahil Shikalgar , Md. Noor-E-Alam

We present a sample path dependent measure of causal influence between two time series. The proposed measure is a random variable whose expected sum is the directed information. A realization of the proposed measure may be used to identify…

信息论 · 计算机科学 2018-10-15 Gabriel Schamberg , Todd P. Coleman

Instrumental variable methods are among the most commonly used causal inference approaches to deal with unmeasured confounders in observational studies. The presence of invalid instruments is the primary concern for practical applications,…

统计方法学 · 统计学 2023-04-18 Zijian Guo

The study of causality or causal inference - how much a given treatment causally affects a given outcome in a population - goes way beyond correlation or association analysis of variables, and is critical in making sound data driven…

数据库 · 计算机科学 2017-08-09 Sudeepa Roy , Babak Salimi

A fundamental challenge in causal inference with observational data is correct specification of a causal model. When there is model uncertainty, analysts may seek to use estimates from multiple candidate models that rely on distinct, and…

统计方法学 · 统计学 2026-03-03 Rohit Bhattacharya , Ina Ocelli , Ted Westling

One of the fundamental challenges in drawing causal inferences from observational studies is that the assumption of no unmeasured confounding is not testable from observed data. Therefore, assessing sensitivity to this assumption's…

统计方法学 · 统计学 2024-06-25 Md Abdul Basit , Mahbub A. H. M. Latif , Abdus S Wahed

Causal inference on multiple non-independent outcomes raises serious challenges, because multivariate techniques that properly account for the outcome's dependence structure need to be considered. We focus on the case of binary outcomes…

统计方法学 · 统计学 2018-05-11 Monia Lupparelli , Alessandra Mattei

Deciding on an appropriate intervention requires a causal model of a treatment, the outcome, and potential mediators. Causal mediation analysis lets us distinguish between direct and indirect effects of the intervention, but has mostly been…

机器学习 · 计算机科学 2023-06-19 Çağlar Hızlı , ST John , Anne Juuti , Tuure Saarinen , Kirsi Pietiläinen , Pekka Marttinen

Attrition in survey and field experiments presents a challenge for social science research. Common approaches to deal with this problem -- such as complete case analysis, multiple imputation, and weighting methods -- rely on strong…

统计方法学 · 统计学 2026-04-13 Xiangyu Song