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This paper uses a simple optogenetic model to compare the timing distortion between a randomly-generated target spike sequence and an externally-stimulated neuron spike sequence. Optogenetics is an emerging field of neuroscience where…

神经元与认知 · 定量生物学 2020-04-24 Adam Noel , Dimitrios Makrakis , Andrew W. Eckford

Optogenetics is a new tool to study neuronal circuits that have been genetically modified to allow stimulation by flashes of light. We study recordings from single neurons within neural circuits under optogenetic stimulation. The data from…

统计方法学 · 统计学 2016-12-23 Xi Luo , Steven Gee , Vikaas S. Sohal , Dylan S. Small

The effects of spike timing precision and dynamical behavior on error correction in spiking neurons were investigated. Stationary discharges -- phase locked, quasiperiodic, or chaotic -- were induced in a simulated neuron by presenting…

神经元与认知 · 定量生物学 2007-05-23 Michael Stiber

Background: In neurophysiological data, latency refers to a global shift of spikes from one spike train to the next, either caused by response onset fluctuations or by finite propagation speed. Such systematic shifts in spike timing lead to…

Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn, can modulate behavior in live organisms. However, detecting the response to the optical stimulation requires electrophysiology with physical…

We derive a synaptic weight update rule for learning temporally precise spike train to spike train transformations in multilayer feedforward networks of spiking neurons. The framework, aimed at seamlessly generalizing error backpropagation…

神经与进化计算 · 计算机科学 2016-01-11 Arunava Banerjee

Photonic Spiking Neural Networks (PSNN) composed of the co-integrated CMOS and photonic elements can offer low loss, low power, highly-parallel, and high-throughput computing for brain-inspired neuromorphic systems. In addition,…

系统与控制 · 电气工程与系统科学 2023-11-28 Yun-Jhu Lee , Mehmet Berkay On , Luis El Srouji , Li Zhang , Mahmoud Abdelghany , S. J. Ben Yoo

This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a…

神经元与认知 · 定量生物学 2018-09-06 Adam Noel , Shayan Monabbati , Dimitrios Makrakis , Andrew W. Eckford

A single neuron is known to generate almost identical spike trains when the same fluctuating input is repeatedly applied. Here, we study the reliability of spike firing in a pulse-coupled network of oscillator neurons receiving fluctuating…

适应与自组织系统 · 物理学 2015-05-13 Jun-nosuke Teramae , Tomoki Fukai

Spiking neural networks (SNN) hold the promise of being a more biologically plausible, low-energy alternative to conventional artificial neural networks. Their time-variant nature makes them particularly suitable for processing…

机器学习 · 计算机科学 2025-04-10 Jan Debus , Charlotte Debus , Günther Dissertori , Markus Götz

Objective. Long-term potentiation (LTP) is a fundamental mechanism underlying learning and memory, yet its investigation at the network level in vitro remains challenging, particularly when optogenetic stimulation is used. The objective of…

生物物理 · 物理学 2026-02-13 Matteo Dominici , Ilya Auslender , Clara Zaccaria , Yasaman Heydari , Lorenzo Pavesi

This article investigates the emergence of phase synchronization in a network of randomly connected neurons by chemical synapses. The study uses the classic Hodgkin-Huxley model to simulate the neuronal dynamics under the action of a train…

The majority of inherited retinal degenerations are due to photoreceptor cell death. In many cases ganglion cells are spared making it possible to stimulate them to restore visual function. Several studies (Bi et al., 2006; Lin et al.,…

Optical computing could reduce the energy cost of artificial intelligence by leveraging the parallelism and propagation speed of light. However, implementing nonlinear activation, essential for machine learning, remains challenging in…

光学 · 物理学 2026-01-01 Bahadır Utku Kesgin , Gülsüm Yaren Durdu , Uğur Teğin

Today, machine learning tools, particularly artificial neural networks, have become crucial for diverse applications. However, current digital computing tools to train and deploy artificial neural networks often struggle with massive data…

新兴技术 · 计算机科学 2025-02-14 Bora Çarpınlıoğlu , Uğur Teğin

Biotechnology can benefit from dynamic control to improve production efficiency. In this context, optogenetics enables modulation of gene expression using light as an external input, allowing fine-tuning of protein levels to unlock dynamic…

系统与控制 · 电气工程与系统科学 2026-05-11 Sebastián Espinel-Ríos

Neuroprosthesis, as one type of precision medicine device, is aiming for manipulating neuronal signals of the brain in a closed-loop fashion, together with receiving stimulus from the environment and controlling some part of our brain/body.…

神经元与认知 · 定量生物学 2020-01-14 Zhaofei Yu , Jian K. Liu , Shanshan Jia , Yichen Zhang , Yajing Zheng , Yonghong Tian , Tiejun Huang

We investigate the evolution of coherence property of noise-seeded Stokes wave in short (< 1 ps) and long pulse (> 1 ps) regimes. Nonlinear equations expressing the evolution of pump and Stokes wave are solved numerically for both the…

光学 · 物理学 2019-05-22 Partha Mondal , Shailendra K. Varshney

Spike-sorting techniques attempt to classify a series of noisy electrical waveforms according to the identity of the neurons that generated them. Existing techniques perform this classification ignoring several properties of actual neurons…

定量方法 · 定量生物学 2007-05-23 Christophe Pouzat

This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a…

神经元与认知 · 定量生物学 2020-04-24 Adam Noel , Shayan Monabbati , Dimitrios Makrakis , Andrew W. Eckford
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