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Raman spectroscopy provides spectral information related to the specific molecular structures of substances and has been well established as a powerful tool for studying biological tissues and diagnosing diseases. This article reviews…

Spectroscopic analysis of large biomolecules is critical in a number of applications, including medical diagnostics and label-free biosensing. Recently, it has been shown that Raman spectroscopy of proteins can be used to diagnose some…

光学 · 物理学 2017-11-28 S. Hamed Shams Mousavi , Ali A. Eftekhar , Amir H. Atabaki , Ali Adibi

Resonant dielectric nanoparticles (RDNs) made of materials with large positive dielectric permittivity, such as Si, GaP, GaAs, have become a powerful platform for modern light science, enabling various fascinating applications in…

光学 · 物理学 2017-10-30 Alex Krasnok , Martin Caldarola , Nicolas Bonod , Andrea Alú

Ultrafast lasers have become one of the most powerful tools in coherent nonlinear optical spectroscopy. Short pulses enable direct observation of fast molecular dynamics, whereas broad spectral bandwidth offers ways of controlling nonlinear…

化学物理 · 物理学 2015-05-13 X. G. Xu , S. O. Konorov , J. W. Hepburn , V. Milner

Raman microscopy is a powerful method combining non-invasiveness with no special sample preparation. Because of this remarkable simplicity, it has been widely exploited in many fields, ranging from life and materials sciences, to…

Compressive Raman is a recent framework that allows for large data compression of microspectroscopy during its measurement. Because of its inherent multiplexing architecture, it has shown imaging speeds considerably higher than conventional…

In the biochemical sensing field, a fervent research activity related to the development of real time, low cost, compact and high throughput devices for the detection and characterization of natural or synthetic nanoparticles NPs actually…

光学 · 物理学 2014-01-13 Clarissa Martina Campanella

State-of-the-art microscopes use intense lasers that can severely disturb biological processes, function and viability. This introduces hard limits on performance that only quantum photon correlations can overcome. Here we demonstrate this…

Nanotechnology is enabling the development of a new generation of devices which are able to sense, process and communicate, while being in the scale of tens to hundreds of cubic nanometers. Such small, imperceptible devices enhance not only…

系统与控制 · 电气工程与系统科学 2021-10-28 Jennifer Simonjan , Bige D. Unluturk , Ian F. Akyildiz

Raman spectroscopy's capability to provide meaningful composition predictions is heavily reliant on a pre-processing step to remove insignificant spectral variation. This is crucial in biofluid analysis. Widespread adoption of diagnostics…

信号处理 · 电气工程与系统科学 2019-04-05 Emily E Storey , Amr S. Helmy

In chemical processing and bioprocessing, conventional online sensors are limited to measure only basic process variables like pressure and temperature, pH, dissolved O and CO$_2$ and viable cell density (VCD). The concentration of other…

定量方法 · 定量生物学 2020-05-07 Semion Rozov

Surface Enhanced Raman Spectroscopy (SERS) is a well-established technique for enhancing Raman signals. Recently photonic integrated circuits have been used, as an alternative to microscopy based excitation and collection, to probe SERS…

Raman scattering spectroscopy is widely used as an analytical technique in various fields, but its measurement process tends to be slow due to the low scattering cross-section. In the last decade, various broadband coherent Raman scattering…

光学 · 物理学 2025-05-06 Takuma Nakamura , Kazuki Hashimoto , Takuro Ideguchi

Raman spectroscopy, a photonic modality based on the inelastic backscattering of coherent light, is a valuable asset to the intraoperative sensing space, offering non-ionizing potential and highly-specific molecular fingerprint-like…

图像与视频处理 · 电气工程与系统科学 2024-01-18 Ashutosh Raman , Ren A. Odion , Kent K. Yamamoto , Weston Ross , Tuan Vo-Dinh , Patrick J. Codd

Biosensors are essential tools which have been traditionally used to monitor environmental pollution, detect the presence of toxic elements and biohazardous bacteria or virus in organic matter and biomolecules for clinical diagnostics. In…

化学物理 · 物理学 2021-01-08 Aishwaryadev Banerjee , Swagata Maity , Carlos H. Mastrangelo

Early detection of cancer is essential for timely diagnosis and improved patient outcomes. Among emerging technologies, intra-body nanoscale communication offers an innovative solution to identify molecular cues within the human…

新兴技术 · 计算机科学 2026-03-12 Abdollah Rezagholi , Sergi Abadal , Filip Lemic , Eduard Alarcon , Ethungshan Shitiri

In nanomechanical photothermal absorption spectroscopy and microscopy, the measured substance becomes a part of the detection system itself, inducing a nanomechanical resonance frequency shift upon thermal relaxation. Suspended,…

仪器与探测器 · 物理学 2023-06-30 Robert G. West , Kostas Kanellopulos , Silvan Schmid

Confocal Raman microscopy offers a particular pathway for monitoring chemical "fingerprints" of intracellular components like the cell membrane, organelles, and nucleus. Nevertheless, conventional Raman acquisitions of fixed or randomly…

Vibrational Raman scattering -- a process where light exchanges energy with a molecular vibration through inelastic scattering -- is most fundamentally described in a quantum framework where both light and vibration are quantized. When the…

Optical detection of nanoscale objects without relying on fluorescence is a current challenge due to their extremely weak interaction with light. Resonator-enhanced absorption microscopy is a novel tool to heavily boost the light-matter…

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