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When a system is in equilibrium, external perturbations yield a time series of non-equilibrium distributions, and recent experimental techniques give access to the non-equilibrium data that may contain critical information. Jinwoo and…

统计力学 · 物理学 2023-01-16 Lee Jinwoo

Micro- and nano-scale systems driven by rapid changes in control parameters (control protocols) dissipate significant energy. In the fast-protocol limit, we find that protocols that minimize dissipation at fixed duration are universally…

统计力学 · 物理学 2021-08-11 Steven Blaber , Miranda D. Louwerse , David A. Sivak

Biological molecular machines convert free energy between different forms in cells, often at high efficiency. Optimal control theory provides a framework to elucidate design principles governing energetically efficient driving. Here, we use…

生物物理 · 物理学 2025-06-12 W. Callum Wareham , David A. Sivak

Molecular motors convert chemical energy into mechanical work while operating in an environment dominated by Brownian motion. The aim of this paper is to explore the flow of energy between the molecular motors and its surroundings, in…

统计力学 · 物理学 2011-05-06 Yunxin Zhang

Optimizing the energy efficiency of driving processes provides valuable insights into the underlying physics and is of crucial importance for numerous applications, from biological processes to the design of machines and robots. Knowledge…

软凝聚态物质 · 物理学 2024-04-02 Sarah A. M. Loos , Samuel Monter , Felix Ginot , Clemens Bechinger

Self-organization creates new order and shifts sub-boundaries while reorganizing energy and entropy within a control volume. This article examines pathway selection and tests whether maximizing the entropy generation rate can forecast…

材料科学 · 物理学 2026-03-10 J. A. Sekhar

Physical systems driven away from equilibrium by an external controller dissipate heat to the environment; the excess entropy production in the thermal reservoir can be interpreted as a "cost" to transform the system in a finite time. The…

统计力学 · 物理学 2024-12-31 Jérémie Klinger , Grant M. Rotskoff

The cost of information processing in physical systems calls for a trade-off between performance and energetic expenditure. Here we formulate and study a computation-dissipation bottleneck in mesoscopic systems used as input-output devices.…

统计力学 · 物理学 2023-07-06 Alessandro Ingrosso , Emanuele Panizon

Transferring a physical system from an initial to a final state while minimizing energetic losses is an interdisciplinary control problem that bridges stochastic thermodynamics and optimal transport theory. Recent research typically…

统计力学 · 物理学 2026-02-23 Jann van der Meer , Andreas Dechant

Metabolic reactions of single-cell organisms are routinely observed to become dispensable or even incapable of carrying activity under certain circumstances. Yet, the mechanisms as well as the range of conditions and phenotypes associated…

分子网络 · 定量生物学 2009-01-21 Takashi Nishikawa , Natali Gulbahce , Adilson E. Motter

The excess work required to drive a stochastic system out of thermodynamic equilibrium through a time-dependent external perturbation is directly related to the amount of entropy produced during the driving process, allowing excess work and…

统计力学 · 物理学 2021-03-15 Steven J Large , Jannik Ehrich , David A Sivak

Biological molecular machines are bifunctional enzymes that catalyze two processes: one donating free energy and the other accepting it. Recent studies show that most protein enzymes have rich stochastic dynamics of transitions between the…

生物物理 · 物理学 2023-02-02 Michal Kurzynski , Przemyslaw Chelminiak

We study the statistics of the efficiency in a class of isothermal cyclic machines with realistic coupling between the internal degrees of freedom. We derive, under fairly general assumptions, the probability distribution function for the…

统计力学 · 物理学 2019-01-30 Marc Suñe , Alberto Imparato

Complex systems can convert energy imparted by nonequilibrium forces to regulate how quickly they transition between long lived states. While such behavior is ubiquitous in natural and synthetic systems, currently there is no general…

统计力学 · 物理学 2021-04-28 Benjamin Kuznets-Speck , David T. Limmer

Microbes require several complex organic molecules for growth. A species may obtain a required factor by taking up molecules released by other species or by synthesizing the molecule. The patterns of uptake and synthesis set a flow of…

种群与进化 · 定量生物学 2014-02-27 Steven A. Frank

Free energy landscapes encode the kinetics, intermediates, and transition states that govern molecular processes and are thus a key target of single biomolecule research. Typical approaches to deriving optimal, error-minimizing,…

生物物理 · 物理学 2025-11-25 Oliver Cheng , Zosia Adamska , Michael P. Brenner , Megan C. Engel

Single-molecule experiments have found near-perfect thermodynamic efficiency in the rotary motor F1-ATP synthase. To help elucidate the principles underlying nonequilibrium energetic efficiency in such stochastic machines, we investigate…

统计力学 · 物理学 2019-09-05 Joseph N. E. Lucero , Aliakbar Mehdizadeh , David A. Sivak

We consider a molecular machine described as a Brownian particle diffusing in a tilted periodic potential. We evaluate the absorbed and released power of the machine as a function of the applied molecular and chemical forces, by using the…

统计力学 · 物理学 2012-03-23 N. Golubeva , A. Imparato , L. Peliti

Information processing machines at the nanoscales are unavoidably affected by thermal fluctuations. Efficient design requires understanding how nanomachines can operate at minimal energy dissipation. In this letter we focus on mechanical…

统计力学 · 物理学 2015-03-17 Paolo Muratore-Ginanneschi , Kay Schwieger

The efficiency at maximum power (EMP) for tight-coupling molecular motors is investigated within the framework of irreversible thermodynamics. It is found that the EMP depends merely on the constitutive relation between the thermodynamic…

统计力学 · 物理学 2013-12-13 Z. C. Tu